TRISH Research
Deep space exploration – beyond low Earth orbit, to the Moon, Mars, and beyond – presents unique mental, physical, and emotional challenges. To thrive in deep space, humans will need practical solutions to problems like neurocognitive changes, radiation exposure and other stressors. TRISH leads a national effort in translating emerging terrestrial biomedical research and technology development into applied human risk-mitigation strategies, helping humans thrive wherever they explore, in space or on Earth.
TRISH funds both early-stage, high-risk research with the potential for high impact as well as more mature, translation-ready technologies that can be employed in spaceflight. This forward-looking work could create a paradigm shift in healthcare during space exploration enabling us to reach new frontiers in healthcare on Earth.
TRISH Scientific Initiatives Overview
EXPAND Advancing Commercial Space Research
As commercial spaceflight takes off, the EXPAND Program seizes new opportunities to study human adaption and physiology. TRISH works with commercial spaceflight providers and their participants to increase engagement in human research and collect essential biomedical data before, during and after spaceflight. This information is securely maintained in the Institute’s centralized EXPAND database, the world’s first and only private space health research repository. It will offer researchers unparalleled access to biological samples and data from a wide pool of spaceflight participants.
HERMES A Medical System Architecture
To enable an effective health and performance system, healthcare providers and spaceflight crews need access to current and comprehensive health and performance data to make evidence-based decisions. However, there will be a variety of sources before, during and after a mission that contribute health and performance data creating a fragmented record and inconsistent access. TRISH’s goal is to enable a robust and democratized heath record that accompanies the astronaut making health information and data from a variety of sources useful and accessible, even when the crew is far from Earth.
SENTINEL Tissue-Chips
TRISH is accelerating human tissue chips system technologies to provide an advanced biological platform to study long-duration deep space exposure. These advanced systems will be automated and have embedded analytic capability allowing researchers to characterize the biological effects of deep space exposure and test personalized countermeasures to protect humans exploring space without requiring samples be returned to Earth for analysis.
Learn more about TRISH scientific initiatives in our Broad Institute Announcement (BIA):
Current and Previously TRISH-Funded Scientific Studies
To date, TRISH has funded over 140 scientific studies to advance human health in space and further exploration.
Completed projects are categorized by funding start date.
Metabolic Measurement, Manipulation, and Countermeasure Strategies
Principal Investigator: Katharyn Flickinger, Ph.D.
Institution: University of Pittsburgh
Project Start Date: Sept. 1, 2024
Streamlined Molecular Farming of VLP Therapeutics in Space
Principal Investigator: Patrick Opdensteinen, M.Sc., Ph.D.
Institution: University of California, San Diego
Project Start Date: Sept. 1, 2024
Defining the figures of merit for an on-demand Astropharmacy
Principal Investigator: Lynn Rothschild, Ph.D.
Institution: NASA Ames Research Center
Project Start Date: Sept. 1, 2024
Bone metabolism is altered by skeletal unloading and nutrient limitation during long-duration spaceflight
Principal Investigator: Carolyn Chlebek, Ph.D.
Institution: MaineHealth
Project Start Date: Aug. 1, 2024
Figures of Merit for Space-Based Production of a Therapeutic in Plants
Principal Investigator: Karen McDonald, Ph.D.
Institution: University of California, Davis
Project Start Date: July 1, 2024
Creating non-human tended microphysiological systems (PI: Gerecht)
Principal Investigator: Sharon Gerecht, Ph.D.
Institution: Duke University
Project Start Date: Feb. 1, 2024
Creating non-human tended microphysiological systems (PI: Vunjak-Novakovic)
Principal Investigator: Gordana Vunjak-Novakovic, Ph.D.
Institution: Columbia University
Project Start Date: Feb. 1, 2024
The Effect of Negative Pressure Ventilation on Intracranial Pressure (NPV ICP)
Principal Investigator: Mohammad Hirzallah, MD
Institution: Baylor College of Medicine
Project Start Date: Jan. 1, 2024
Extend Healthy Life in Space by Characterizing Radiation Induced Pro-Inflammatory Response and Enhancing Wound Repair and Recovery with Radiation Mitigating Thrombin Peptide
Principal Investigator: Stephanie Dudzinski, M.D., Ph.D.
Institution: The University of Texas M.D. Anderson Cancer Center
Project Start Date: Dec. 1, 2023
Effect of deconditioning on gravitational dose-response curves for cardiovascular and ocular variables in men and women
Principal Investigator: Adrien Robin, Ph.D.
Institution: Texas A&M Research Foundation
Project Start Date: Dec. 1, 2023
Defining Gut Microbial Changes to Space-Like Radiation to Develop a Radiation-Resistant Microbiome
Principal Investigator: Katherine Wozniak, Ph.D.
Institution: Baylor College of Medicine
Project Start Date: Aug. 1, 2023
Design of an Extracellular Vesicle Approach to Protect Human Health in Space
Principal Investigator: Marni Boppart, Ph.D.
Institution: University of Illinois at Urbana-Champaign
Project Start Date: July 1, 2023
Controlling NAD(P) hyper-oxidation to regulate repair and maintenance processes in humans in space.
Principal Investigator: Marie Migaud, Ph.D.
Institution: University of South Alabama
Project Start Date: April 1, 2023
Fundamentals of Ultrasound - Artemis Training Solution
Principal Investigator: Aidan Zerdoum, Ph.D.
Institution: Level Ex
Project Start Date: Oct. 1, 2022
Using human organoids and fossilized remains from extinct hominins to unlock the secrets of torpor/hibernation
Principal Investigator: Christopher Porada, Ph.D.
Institution: Wake Forest Institute for Regenerative Medicine
Project Start Date: July 1, 2022
Enhancing eXploration Platforms and ANalog Definition Intracranial Pressure (EXPAND-ICP)
Principal Investigator: Eric Michael Bershad, MD
Institution: Baylor College of Medicine
Project Start Date: May 1, 2022
REM and CAD Radiation Monitoring for Private Astronaut Spaceflight
Principal Investigator: Stuart George, Ph.D.
Institution: University of Houston
Project Start Date: May 1, 2022
Cognitive and Physiologic Responses in Commercial Space Crew on Short-Duration Missions
Principal Investigator: Mathias Basner, MD, PhD, MSc
Institution: University of Pennsylvania
Project Start Date: Dec. 1, 2021
Otolith and Posture Evaluation II
Principal Investigator: Mark Shelhamer, ScD
Institution: Johns Hopkins Medical School
Project Start Date: Nov. 1, 2021
Imaging-Based Human Physiology Research and Innovation in Early Spaceflight: Inspiration4 Mission
Principal Investigator: Ashot Sargsyan, M.D.
Institution: KBR
Project Start Date: May 1, 2021
High-density dry-electrode EEG in LEO spaceflight
Principal Investigator: Michael Funke, M.D., Ph.D
Institution: The University of Texas Health Science Center at Houston
Project Dates: July 1, 2023 – June 30, 2024
Bench Testing of the M.scio and Lumbar Catheter for the Pilot Feasibility Study of Safety and Effectiveness of Telemetric ICP in Astronauts Before, During, and After Commercial Orbital Spaceflight
Principal Investigator: Anders Eklund, Ph.D.
Institution: Umeå University
Project Dates: Dec. 1, 2022 – Feb. 29, 2024
Pilot Feasibility Study of Safety and Effectiveness of Telemetric Intracranial Pressure Monitoring in Astronauts Before, During, and After Commercial Orbital Spaceflight
Principal Investigator: Michael A. Williams, M.D.
Institution: University of Washington
Project Dates: Nov. 1, 2022 – Feb. 29, 2024
Identifying Genetic Factors in Radiation Injury with Pooled Single Cell Sequencing
Principal Investigator: Xu Cao, Ph.D.
Institution: Stanford University
Project Dates: Sept. 1, 2022 – Aug. 31, 2024
Systematic Assessment of Noisy Galvanic Vestibular Stimulation as a Sensorimotor Countermeasure
Principal Investigator: David Temple, Ph.D.
Institution: University of Colorado at Boulder
Project Dates: Sept. 1, 2022 – Aug. 31, 2024
The use of two new ground-based models of deep space travel to study the role of mitochondria and oxidative stress in cardiovascular effects.
Principal Investigator: Ashley Nemec-Bakk, Ph.D.
Institution: University of Arkansas for Medical Sciences
Project Dates: Aug. 1, 2022 – July 31, 2024
Can Humans Hibernate at Warm Temperatures?
Principal Investigator: Allyson Hindle, Ph.D.
Institution: University of Nevada-Las Vegas
Project Dates: July 1, 2022 – Aug. 31, 2024
Cold-Sleep for Long-duration Spaceflight
Principal Investigator: Clifton Callaway, MD, PhD
Institution: University of Pittsburgh
Project Dates: June 1, 2022 – Oct. 31, 2024
The effect of isochoric supercooling on human liver metabolic function
Principal Investigator: Tammy Chang, M.D., Ph.D.
Institution: University of California, San Francisco
Project Dates: June 1, 2022 – May 31, 2024
Space-Feasible Body Composition and Body Shape Analysis for Long-Duration Missions II
Principal Investigator: John Shepherd, Ph.D.
Institution: University of Hawaii
Project Dates: May 1, 2022 – Sept. 30, 2024
Regulatory Feasibility Study of Implantation of a Telemetric ICP Sensor in Commercial Spaceflight Participants
Principal Investigator: Michael A. Williams, M.D.
Institution: University of Washington
Project Dates: April 1, 2022 – March 31, 2023
Musculoskeletal Response to Disuse in a Genetically Diverse Mouse Population
Principal Investigator: Michael Friedman, Ph.D.
Institution: Virginia Commonwealth University
Project Dates: Jan. 1, 2022 – Dec. 31, 2022
Measuring Pre-,in-, and Post-flight Refractive Errors (Hyperopic Shift) in Space Adventures Flight Tourists and Crew
Principal Investigator: Shivang Dave, Ph.D.
Institution: PlenOptika, Inc.
Project Dates: Nov. 1, 2021 – Oct. 31, 2022
Ionizing radiation and immune responses: exploring sex differences
Principal Investigator: Kaylin Didier, Ph.D.
Institution: University of Wisconsin
Project Dates: Sept. 1, 2021 – Dec. 31, 2023
Countermeasure Development Against Myocardial Mitochondrial Stress by Space Radiation Exposure
Principal Investigator: James Jahng
Institution: Stanford University
Project Dates: Sept. 1, 2021 – Aug. 31, 2023
Investigating plantar somatosensory noise as a countermeasure for balance and locomotion impairments in simulated lunar and Martian gravity
Principal Investigator: Heather R McGregor
Institution: University of Florida
Project Dates: Sept. 1, 2021 – Aug. 31, 2023
Stress Response and Neurovestibular Compensation and the Potential Ameliorative Effects of Team Support
Principal Investigator: Mallika Sarma, Ph.D.
Institution: Johns Hopkins University
Project Dates: Aug. 1, 2021 – July 31, 2023
Virtual Environment Oculometrics in Low-Earth-Orbit (VEO in LEO)
Principal Investigator: Josh Ruben
Institution: Z3VR
Project Dates: May 1, 2021 – Jan. 31, 2024
Cognitive Performance in Relation to Commercial Space Crew Behavior and Spacecraft Environment
Principal Investigator: Mathias Basner, MD, PhD, MSc
Institution: University of Pennsylvania
Project Dates: May 1, 2021 – April 30, 2022
Otolith and Posture Evaluation
Principal Investigator: Mark Shelhamer
Institution: Johns Hopkins Medical School
Project Dates: May 1, 2021 – April 30, 2022
Space Biospecimen Collection and Accelerated Test for In-Flight Mission
Principal Investigator: Frederic Zenhausern, Ph.D.
Institution: University of Arizona
Project Dates: May 1, 2021 – April 30, 2022
Timepix-based Radiation Environment Monitor for SpaceX (TREMS)
Principal Investigator: Lawrence Pinsky, Ph.D.
Institution: University of Houston
Project Dates: May 1, 2021 – Sept. 30, 2021
Mechanistic Insights Into the Combined Chronic Impact of Spaceflight and Aging Cardiovascular Physiology
Principal Investigator: Heather Allaway, Ph.D.
Institution: Texas A&M Research Foundation
Project Dates: Jan. 1, 2021 – Aug. 31, 2021
Machine Learning as a Countermeasure to Spatial Disorientation in a Spaceflight Analog Environment
Principal Investigator: Vivekanand Vimal, Ph.D.
Institution: Brandeis University
Project Dates: Dec. 1, 2020 – April 30, 2022
Medical Data Acquisition and Handling in Commercial Space
Principal Investigator: Jaime Mateus, Ph.D.
Institution: Space Exploration Technologies
Project Dates: Dec. 1, 2020 – Nov. 30, 2021
Effects of Chronic High LET Radiation on the Human Heart
Principal Investigator: Michael Weil, Ph.D.
Institution: Colorado State University
Project Dates: Nov. 1, 2020 – April 30, 2024
Conversational Intelligent Agents For Astronaut Behavioral Health and Performance
Principal Investigator: Rachna Dhamija, Ph.D.
Institution: Ejenta
Project Dates: November 1, 2020 – December 31, 2021
Oculometric Cognition Testing and Analysis in Virtual Environments (OCTAVE)
Principal Investigator: Josh Ruben
Institution: Z3VR
Project Dates: Nov. 1, 2020 – Dec. 31, 2021
Development of Next-Generation Probiotics to Combat Mental Health Risks for Space Travel
Principal Investigator: Philip Strandwitz
Institution: Holobiome, Inc.
Project Dates: Nov. 1, 2020 – Oct. 31, 2021
Using Human Stem-Cell Derived Vascular, Neural and Cardiac 3D Tissues to Determine Countermeasures for Radiation
Principal Investigator: Sharon Gerecht, Ph.D.
Institution: Duke University
Project Dates: Oct. 1, 2020 – Aug. 31, 2024
Human multi-tissue platform to study effects of space radiation and countermeasures
Principal Investigator: Gordana Vunjak-Novakovic, Ph.D.
Institution: Columbia University
Project Dates: Oct. 1, 2020 – Dec. 31, 2023
Use of Microbial Based Countermeasures to Mitigate Radiation Induced Intestinal Damage
Principal Investigator: Sarah Blutt, Ph.D.
Institution: Baylor College of Medicine
Project Dates: Oct. 1, 2020 – Sept. 30, 2023
Counteracting Space Radiation by Targeting Neurogenesis in a Human Brain Organoid Model
Principal Investigator: Mirjana Maletic-Savatic, MD, PhD
Institution: Baylor College of Medicine
Project Dates: Oct. 1, 2020 – Sept. 30, 2023
Development of Machine Learning-derived Microbiological and Immune Signatures: Applications in Adaptive Risk Assessment of Infectious Disease During Spaceflight
Principal Investigator: Kristyn Hoffman, Ph.D.
Institution: KBRWyle
Project Dates: Oct. 1, 2020 – Sept. 30, 2022
Investigating the Effects of Simulated Microgravity Duration and Connexin 43 Deficiency on Bone Fracture Healing
Principal Investigator: Evan Buettmann, Ph.D.
Institution: Virginia Commonwealth University
Project Dates: Sept. 1, 2020 – Aug. 31, 2023
Medical Oxygen Delivery System in Exploration Atmosphere Minimizing the Risk of Fire
Principal Investigator: Arif Rahman, Ph.D.
Institution: University of Hawaii
Project Dates: Sept. 1, 2020 – Aug. 31, 2022
Manipulating Sleep Architecture as an Operational Countermeasure
Principal Investigator: Matthew Gaidica, Ph.D.
Institution: University of Michigan
Project Dates: Aug. 1, 2020 – July 31, 2023
Microgravity and Partial Gravity Effects on Hepatic Organoid Steatosis and Function
Principal Investigator: Maria Sekyi
Institution: University of California, San Francisco
Project Dates: Aug. 1, 2020 – Sept. 30, 2021
Space-based Paper Microfluidic Vertical Flow Assay for Rapid Multiplex Diagnostics (VFD) in COVID-19 Pandemic Response and Recovery
Principal Investigator: Frederic Zenhausern, Ph.D.
Institution: University of Arizona
Project Dates: June 1, 2020 – Sept. 30, 2020
Mixed Reality (MR) Care-Delivery Guidance System to Support Medical Event Management on Long Duration Exploration Missions
Principal Investigator: Roger Daglius Dias, MD, Ph.D.
Institution: Brigham and Women's Hospital
Project Dates: April 1, 2020 – March 31, 2022
A Multimodal Wearable System for Deep Space Monitoring of Stress and Anxiety
Principal Investigator: Wei Gao, Ph.D.
Institution: California Institute of Technology
Project Dates: April 1, 2020 – March 31, 2022
Actionable Deep Space Stroke Detection with Deep Learning and Retinal Imaging
Principal Investigator: Luca Giancardo, Ph.D.
Institution: The University of Texas Health Science Center at Houston
Project Dates: April 1, 2020 – March 31, 2022
Immobilization and Stabilization of Biocatalysts for Efficient Pharmaceutical Manufacturing
Principal Investigator: David Howell, Ph.D.
Institution: Bondwell Technologies Inc.
Project Dates: April 1, 2020 – March 31, 2022
Just in Time Medications from Gastrointestinal Resident Microbial Systems
Principal Investigator: Robert Langer, Sc.D.
Institution: Massachusetts Institute of Technology
Project Dates: April 1, 2020 – March 31, 2022
A Plant-Based Platform for "Just in Time" Medications
Principal Investigator: Karen McDonald, Ph.D.
Institution: University of California, Davis
Project Dates: April 1, 2020 – March 31, 2022
Development of a Self-Imaging, Compact, Retinal Imaging System for Human Spaceflight Applications Phase 2b
Principal Investigator: Bob Main
Institution: Web Vision
Project Dates: March 1, 2020 – June 30, 2020
Investigation of Blood-based Circulating Biomarkers of Responses to Space Radiation
Principal Investigator: Eloise Pariset, Ph.D.
Institution: NASA Ames Research Center
Project Dates: Nov. 1, 2019 – March 31, 2021
Monitoring Biomarkers for Muscular Atrophy Using Nanoelectronic Chip for Astronaut Health
Principal Investigator: Morgan J. Anderson, Ph.D.
Institution: NASA Ames Research Center
Project Dates: Sept. 1, 2019 – Aug. 31, 2021
Space-Feasible Body Composition and Body Shape Analysis for Long Duration Missions
Principal Investigator: John Shepherd, Ph.D.
Institution: University of Hawaii
Project Dates: Sept. 1, 2019 – Aug. 31, 2021
Scientific Physical and Operations Characterization (SPOC) - Capturing Physical Terrestrial Fieldwork in Context
Principal Investigator: Rachel Vitali, Ph.D.
Institution: University of Michigan
Project Dates: Sept. 1, 2019 – Aug. 31, 2020
Effects of Galactic Cosmic Radiation on Translationally-Relevant Cognitive Behaviors and Response to Social Stress
Principal Investigator: Frederico C. Kiffer, Ph.D.
Institution: Children's Hospital of Philadelphia
Project Dates: Aug. 1, 2019 – July 31, 2022
In Situ Expression Analysis of Therapeutic Microbes with Gastrointestinal Devices
Principal Investigator: Miguel Jimenez, Ph.D.
Institution: Massachusetts Institute of Technology
Project Dates: Aug. 1, 2019 – April 30, 2021
Investigating the Combinatorial Effects of Intraocular Pressure and Hypobaric Hypoxia on Corneal Function
Principal Investigator: Andrew Ford, Ph.D.
Institution: Tufts University
Project Dates: Aug. 1, 2019 – March 31, 2021
Virtual Human Simulation Framework
Principal Investigator: Erik Funkhouser
Institution: Level Ex
Project Dates: Aug. 1, 2019 – July 31, 2020
Retired Astronauts Medical Data Repository (RADAR): a Feasibility Project
Principal Investigator: Bonnie Dunbar, Ph.D.
Institution: Texas Engineering Experiment Station
Project Dates: June 1, 2019 – Oct. 31, 2020
Organs on a Chip Platform for Assessing Cosmic Radiation Damage
Principal Investigator: Gordana Vunjak-Novakovic, Ph.D.
Institution: Columbia University
Project Dates: June 1, 2019 – Sept. 30, 2020
Impact of Radiation Exposure on a 3D In Vitro Model of Human Bone Marrow
Principal Investigator: Steven George, Ph.D.
Institution: University of California, Davis
Project Dates: June 1, 2019 – Aug. 31, 2020
The Ex-Vivo Human Translaminar Autonomous System to Study SANS Pathogenesis
Principal Investigator: Tasneem Sharma, Ph.D.
Institution: Indiana University School of Medicine
Project Dates: June 1, 2019 – Aug. 31, 2020
Establish the Feasibility of Engineering a Human Optic-Nerve-On-A-Chip as an In Vitro Model for SANS Research
Principal Investigator: Anup Dutt Sharma, Ph.D.
Institution: AxoSim, Inc.
Project Dates: June 1, 2019 – May 31, 2020
Non-contact Sleep, Vitals, and Behavior Sensing
Principal Investigator: Dina Katabi, Ph.D.
Institution: Emerald Innovations, Inc.
Project Dates: May 1, 2019 – Sept. 30, 2020
VisualDx Clinical Decision Support for Ultrasound
Principal Investigator: Art Papier, M.D.
Institution: VisualDx
Project Dates: May 1, 2019 – July 31, 2020
Objective Refraction with Self-operable, Lightweight Autorefractor
Principal Investigator: Shivang Dave, Ph.D.
Institution: PlenOptika, Inc.
Project Dates: May 1, 2019 – April 30, 2020
The Cytotracker: Point-of-use Complete Blood Count
Principal Investigator: Mehdi Javanmard, Ph.D.
Institution: Rizlab Health, Inc.
Project Dates: May 1, 2019 – April 30, 2020
EmbraceX
Principal Investigator: Matteo Lai
Institution: Empatica, Inc.
Project Dates: May 1, 2019 – April 30, 2020
Cell-free Production of Pharmaceutical-grade Biologics
Principal Investigator: Felix Moser, Ph.D.
Institution: Synlife
Project Dates: May 1, 2019 – April 30, 2020
Project Atlas
Principal Investigator: Josh Ruben
Institution: Z3VR
Project Dates: May 1, 2019 – April 30, 2020
InnaMed TeleLab Platform
Principal Investigator: Anup Singh
Institution: InnaMed, Inc.
Project Dates: May 1, 2019 – April 30, 2020
Room Temperature Stable Basic Metabolic Panel
Principal Investigator: Elizabeth Palaima, Ph.D.
Institution: Ativa Medical Corporation
Project Dates: May 1, 2019 – March 31, 2020
Intelligent Assistance for Accurate and Reliable Lymphatic Data Collection
Principal Investigator: Matthew Johnson, Ph.D.
Institution: Institute for Human and Machine Cognition
Project Dates: March 1, 2019 – March 31, 2020
Human-centered Design Augmentation of the Vertical Flow Paper-based Health Monitoring Platform Principal Investigator: Jian Gu, Ph.D.
Institution: University of Arizona
Project Dates: March 1, 2019 – Feb. 29, 2020
Create a Proof of Concept Device for a Compact Multi-VCSEL Swept Source-OCT Including Associated Signal Analysis Algorithms, and Data Review Software for Deep Space Missions
Principal Investigator: Ryo Kubota, Ph.D.
Institution: Acucela, Inc
Project Dates: March 1, 2019 – Feb. 29, 2020
Design of “Autonomous Medical Response Assistant” Interface Prototype for Long Duration Spaceflight
Principal Investigator: Jessica J. Marquez, Ph.D.
Institution: NASA Ames Research Center
Project Dates: March 1, 2019 – Feb. 29, 2020
Translational Research for Autonomous Care Coordination (TRACC)
Principal Investigator: Gary Riccio, Ph.D.
Institution: Nascent Science & Technology, LLC
Project Dates: March 1, 2019 – Feb. 29, 2020
Performance Enhancement Through Multi-Modal Stochastic Resonance
Principal Investigator: Allison Anderson, Ph.D.
Institution: University of Colorado at Boulder
Project Dates: Jan. 1, 2019 – Dec. 31, 2021
Genetic Variability in Microgravity-Induced Bone and Muscle Loss
Principal Investigator: Michael Friedman, Ph.D.
Institution: Virginia Commonwealth University
Project Dates: Jan. 1, 2019 – Dec. 31, 2021
Gene Therapy Countermeasures For Detrimental Effects of Space Radiation
Principal Investigator: Dawn Bowles, Ph.D.
Institution: Duke University Medical Center
Project Dates: Jan. 1, 2019 – Sept. 30, 2021
Nucleic Acid Therapy Platform for Real-Time Countermeasures During Spaceflight Missions
Principal Investigator: Anushree Chatterjee, Ph.D.
Institution: University of Colorado at Boulder
Project Dates: Jan. 1, 2019 – Sept. 30, 2021
miRNA Signature Detection and Countermeasures Against HZE Radiation Exposure for Tissue Degeneration
Principal Investigator: Afshin Beheshti, Ph.D.
Institution: KBRWyle
Project Dates: Jan. 1, 2019 – Aug. 31, 2021
Boosting Brain Metabolism in Spaceflight with Transcranial Photobiomodulation
Principal Investigator: Jacek Dmochowski, Ph.D.
Institution: City College of New York
Project Dates: Jan. 1, 2019 – Aug. 31, 2021
Safety and Efficacy of an Accelerated Protocol of Intermittent Theta Burst Transcranial Magnetic Stimulation (TMS) to Enhance Performance and Promote Resilience in Astronauts
Principal Investigator: Donna Roberts, M.D.
Institution: Medical University of South Carolina
Project Dates: Jan. 1, 2019 – Aug. 31, 2021
Evaluation of SmartSleep Technology for Improving the Efficiency and Restorative Quality of Sleep in Healthy Adults in Order to Mitigate Cognitive Performance Deficits Due to Sleep Restriction and Emergency Awakenings
Principal Investigator: David F. Dinges, Ph.D.
Institution: University of Pennsylvania
Project Dates: Jan. 1, 2019 – June 30, 2021
Wearable Modular Focused Ultrasound Systems for Non-Invasive Stimulation of the Human Brain During Deep Space Exploration
Principal Investigator: Seung-Schik Yoo, Ph.D.
Institution: Brigham and Women's Hospital
Project Dates: Jan. 1, 2019 – June 30, 2021
Co-Optimization of Duckweed Biomass, Nutritional Quality & Input-Use Efficiency
Principal Investigator: Barbara Demmig-Adams, Ph.D.
Institution: University of Colorado at Boulder
Project Dates: Jan. 1, 2019 – April 30, 2021
Photobiomodulation to Ameliorate Neuronal Degeneration and Cognitive Decline after Mixed Field Irradiation
Principal Investigator: Antino Allen, Ph.D.
Institution: University of Arkansas at Little Rock
Project Dates: Jan. 1, 2019 – Dec. 31, 2020
Advanced Algorithms for the Prediction of Adverse Cognitive and Behavioral Conditions in Space
Principal Investigator: Mathias Basner, MD, PhD, MSc
Institution: University of Pennsylvania
Project Dates: Jan. 1, 2019 – Dec. 31, 2020
Genetically Minimizing Non-Edible Portions of Plants for Space Flight Applications
Principal Investigator: Robert Jinkerson, Ph.D.
Institution: University of California, Riverside
Project Dates: Jan. 1, 2019 – Dec. 31, 2020
Silk Composite Biomaterials for Shielding Medications in Space
Principal Investigator: David L. Kaplan, Ph.D.
Institution: Tufts University
Project Dates: Jan. 1, 2019 – Dec. 31, 2020
Integrative Personalized Omics Profiling Next Steps: Detection and Classification of Deviations from Wellness
Principal Investigator: George Mias, Ph.D.
Institution: Michigan State University
Project Dates: Jan. 1, 2019 – Dec. 31, 2020
OASIS: Optimizing Auditory Stimulation to Improve Cognitive Performance Using SmartSleep
Principal Investigator: Giulio Tononi, M.D., Ph.D.
Institution: University of Wisconsin
Project Dates: Jan. 1, 2019 – Dec. 31, 2020
Feasibility Study for Potential Radiation Analog
Principal Investigator: Lawrence Pinsky, Ph.D.
Institution: University of Houston
Project Dates: Jan. 1, 2019 – Dec. 31, 2019
Mechanisms of protection from radiation by natural proteins
Principal Investigator: Lindsey Haggett, Ph.D.
Institution: Baylor College of Medicine
Project Dates: Dec. 1, 2018 – Oct. 31, 2021
Predicting individual differences in learning and performance using machine learning methods for dynamic stabilization in a spaceflight analog task
Principal Investigator: Pengyu Hong, Ph.D.
Institution: Brandeis University
Project Dates: Oct. 1, 2018 – Sept. 30, 2019
Autonomous Medical Response Agent (AMRA)
Principal Investigator: Jayant Menon, M.D.
Institution: Nahlia Inc.
Project Dates: Sept. 1, 2018 – Nov. 30, 2019
Miniaturized Diagnostics Platform for Health Assessment in Deep Space
Principal Investigator: Luc Gervais, Ph.D.
Institution: 1Drop Diagnostics
Project Dates: Sept. 1, 2018 – Aug. 31, 2019
VisualDx Augmented Intelligence Project
Principal Investigator: Art Papier, M.D.
Institution: VisualDx
Project Dates: Sept. 1, 2018 – Aug. 31, 2019
Development of Advanced Vision Testing Software for a Goggle-Based Visual Field Device Prototype
Principal Investigator: Bob Main
Institution: Web Vision
Project Dates: Aug. 1, 2018 – May 31, 2020
Create the Technical Requirements, Strategic Roadmap, and Financial Requirements to Develop a Multifunction Ophthalmic Device for Comprehensive Ophthalmic Vision Testing on Deep Space Missions
Principal Investigator: Bob Main
Institution: Web Vision
Project Dates: Aug. 1, 2018 – July 31, 2019
Multipurpose Ultra-Portable Ultrasound Imager with Artificial Intelligence (AI) Capability
Principal Investigator: Ashot Sargsyan, M.D.
Institution: KBR
Project Dates: June 1, 2018 – Sept. 30, 2023
Space Flights Associated Changes in Astronauts Plasma Derived miRNA Expression: Biomarker Identification
Principal Investigator: David A. Goukassian, MD, Ph.D.
Institution: Icahn School of Medicine at Mount Sinai
Project Dates: May 1, 2018 – July 31, 2021
Development of a Vertical Flow paper-based Platform (VFP) for Monitoring Health Outcomes in Inflight Condition
Principal Investigator: Frederic Zenhausern, Ph.D.
Institution: University of Arizona
Project Dates: May 1, 2018 – April 30, 2019
Development of a Goggle-Based Visual Field Device Prototype
Principal Investigator: Bob Main
Institution: Web Vision
Project Dates: April 1, 2018 – March 31, 2020
Synergistic Study of Radioprotection Mechanisms Between Flies and Human Hippocampal Neurons
Principal Investigator: Huichen Wang
Institution: Prairie View A&M University
Project Dates: March 1, 2018 – Feb. 28, 2019
Assessment of Artificial Gravity As a Countermeasure to Cephalad Fluid Shifting (Postdoctoral Fellowship)
Principal Investigator: Karina Marshall-Goebel, Ph.D.
Institution: Massachusetts General Hospital
Project Dates: March 1, 2018 – Dec. 31, 2018
Short Wave Infrared (SWIR) Imaging of Lymphatics
Principal Investigator: Mark Pierce, Ph.D.
Institution: The University of Texas Health Science Center at Houston
Project Dates: Feb. 1, 2018 – Sept. 30, 2018
Will use of long-acting, reversible contraceptives mitigate bone loss in female rats during simulated exploration class missions?
Principal Investigator: Heather Allaway, Ph.D.
Institution: Texas A&M Research Foundation
Project Dates: Jan. 1, 2018 – Dec. 31, 2020
Collaborative Health Innovation Platform (CHIP)
Principal Investigator: Yael Hochberg, Ph.D.
Institution: Rice University
Project Dates: Jan. 1, 2018 – April 30, 2019
Predicting Individual Differences in Learning to Manually Stabilize Attitude in a Space Flight Analog Environment
Principal Investigator: Vivekanand Vimal, Ph.D.
Institution: Brandeis University
Project Dates: Dec. 1, 2017 – Nov. 30, 2020
A mechanistic framework to assess the efficacy of aspirin and other radioprotectors to reduce carcinogenesis by space radiation
Principal Investigator: Micaela Cunha
Institution: Columbia University
Project Dates: Dec. 1, 2017 – May 31, 2019
Novel microfluidic biomarker detection platforms to monitor in vivo effects of solar particle events and galactic cosmic rays radiation, using mice with human hematopoietic systems
Principal Investigator: Christopher Porada, Ph.D.
Institution: Wake Forest Institute for Regenerative Medicine
Project Dates: Nov. 1, 2017 – July 31, 2022
Gastrointestinal devices for long-term in situ delivery of therapeutic microbes
Principal Investigator: Robert Langer, Sc.D.
Institution: Massachusetts Institute of Technology
Project Dates: Nov. 1, 2017 – Oct. 31, 2019
Discovery of human radiation-protection genes and pathways
Principal Investigator: Susan Rosenberg, Ph.D.
Institution: Baylor College of Medicine
Project Dates: Oct. 1, 2017 – Sept. 30, 2021
Mining biology's extremes for new space radiation resistance strategies
Principal Investigator: Donald Fox, Ph.D.
Institution: Duke University Medical Center
Project Dates: Oct. 1, 2017 – Dec. 31, 2020
Cervical lymphatic function quantification and associated molecular changes in response to simulated microgravity
Principal Investigator: Dawn Kernagis, Ph.D.
Institution: Institute for Human and Machine Cognition
Project Dates: Oct. 1, 2017 – April 30, 2020
Creating surgical capabilities for exploration space flight
Principal Investigator: George Pantalos, Ph.D.
Institution: University of Louisville
Project Dates: Oct. 1, 2017 – Sept. 30, 2019
In-flight metagenomic monitoring of infections and associated host responses in astronauts
Principal Investigator: Charles Chiu, Ph.D.
Institution: University of California, San Francisco
Project Dates: Oct. 1, 2017 – Sept. 30, 2019
Personalizing prebiotic therapies for astronauts' gut microbiota
Principal Investigator: Lawrence David, Ph.D.
Institution: Duke University Medical Center
Project Dates: Oct. 1, 2017 – Sept. 30, 2019
Omics in space: Technology development for omics instrumentations and biomolecule measurements
Principal Investigator: Kasthuri Venkateswaran, Ph.D.
Institution: Jet Propulsion Laboratory
Project Dates: Oct. 1, 2017 – Sept. 30, 2019
Label-free photoacoustic lymphatic flowgraphy in simulated microgravity
Principal Investigator: Lihong Wang, Ph.D.
Institution: California Institute of Technology
Project Dates: Oct. 1, 2017 – Sept. 30, 2019
Development of a Self-Imaging, Wide Angle, High Resolution Retinal Imaging System for Human Spaceflight Applications
Principal Investigator: Bob Main
Institution: Web Vision
Project Dates: Sept. 1, 2017 – Aug. 31, 2018
Quantification of the Lymphatic Pump Strength and Assessment of CSF Drainage Into the Lymphatics during HDT
Principal Investigator: Eva Sevick, Ph.D.
Institution: The University of Texas Health Science Center at Houston
Project Dates: May 1, 2017 – Sept. 30, 2018
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