The Division of Pediatric Gastroenterology, Hepatology and Nutrition has dynamic research programs in a variety of areas, both basic and clinical science.
Major Grants Active in 2020
| PI Name | Funding Source | Grant Title |
|---|---|---|
| Bruno Chumpitazi | NIDDK (R03) | Nonbacterial gut microbiome and fructan symptom generation in childhood IBS |
| Bruno Chumpitazi | NASPGHAN | Advancing nutritional science for children with functional dyspepsia |
| Sanjiv Harpavat | NIDDK (K23) | Assessment of a novel newborn screening tool for biliary atresia |
| John Hollier | NIDDK (K23) | A new paradigm for treating functional abdominal pain disorders in children |
| Richard Kellermayer | Pfizer | Advancing provider knowledge about emerging IBD treatment strategies through an advanced pediatric IBD fellowship |
| Krupa Mysore | AASLD | Infection susceptibility and impaired T cell and dendritic cell function in children with chronic liver diseases |
| Geoffrey Preidis | NIDDK (K08) | Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutrition |
| Benjamin Shneider | NIDDK (U01) | BCM/TCH cholestatic liver disease consortium |
| Robert Shulman | NIDDK (T32) | Research training in pediatric gastroenterology |
| Robert Shulman | NIDDK (U01) | Advancing clinical science in pediatric gastroparesis |
Selected Publications
Ten Selected 2020 Publications from the Division of Gastroenterology, Hepatology and Nutrition
- Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, and Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One 15: e0231891, 2020.
- Harpavat S, Garcia-Prats JA, Anaya C, Brandt ML, Lupo PJ, Finegold MJ, Obuobi A, ElHennawy AA, Jarriel WS, and Shneider BL. Diagnostic Yield of Newborn Screening for Biliary Atresia Using Direct or Conjugated Bilirubin Measurements. JAMA 323: 1141-1150, 2020.
- McOmber M, Rafati D, Cain K, Devaraj S, Weidler EM, Heitkemper M, and Shulman RJ. Increased Gut Permeability in First-degree Relatives of Children with Irritable Bowel Syndrome or Functional Abdominal Pain. Clin Gastroenterol Hepatol 18: 375-384 e371, 2020.
- Preidis GA, Soni KG, Suh JH, Halder T, Kim KH, Choi JM, Li F, Devaraj S, Conner ME, Coarfa C, Jung SY, and Moore DD. Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors. Hepatol Commun 4: 1835-1850, 2020.
- Preidis GA, Weizman AV, Kashyap PC, and Morgan RL. AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders. Gastroenterology 159: 708-738 e704, 2020.
- Ruan W, Fishman DS, Lerner DG, Engevik MA, Elmunzer BJ, Walsh CM, and International Pediatric Endoscopy C-A. Changes in Pediatric Endoscopic Practice During the Coronavirus Disease 2019 Pandemic: Results From an International Survey. Gastroenterology 159: 1547-1550, 2020.
- Shiau H, Guffey D, Loomes KM, Seidman C, Ragozzino E, Molleston JP, Schady D, and Leung DH. Biopsy Validated Study of Biomarkers for Liver Fibrosis and Transplant Prediction in Inherited Cholestasis. Hepatol Commun 4: 1516-1526, 2020.
- Shneider BL, Goodrich NP, Ye W, Sawyers C, Molleston JP, Merion RM, Leung DH, Karpen SJ, Kamath BM, Cavallo L, Wang K, Teckman JH, Squires JE, Sundaram SS, Rosenthal P, Romero R, Murray KF, Loomes KM, Jensen MK, Bezerra JA, Bass LM, Sokol RJ, Magee JC, and Childhood Liver Disease Research N. Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease. Hepatol Commun 4: 1694-1707, 2020.
- Soni KG, Dike PN, Suh JH, Halder T, Edwards PT, Foong JPP, Conner ME, and Preidis GA. Early-life malnutrition causes gastrointestinal dysmotility that is sexually dimorphic. Neurogastroenterol Motil 32: e13936, 2020.
- Tessier MEM, Cavallo L, Yeh J, Harpavat S, Hoffman KL, Petrosino JF, and Shneider BL. The Fecal Microbiome in Infants With Biliary Atresia Associates With Bile Flow After Kasai Portoenterostomy. J Pediatr Gastroenterol Nutr 70: 789-795, 2020.
Research Interests of Selected Faculty
| Faculty Name | Key words to research interests |
|---|---|
| Anna Banc Husu | Acute on chronic liver failure, critical care in pediatric liver disease, decompensated cirrhosis |
| Savini Britto | Inflammatory bowel disease, nutrition |
| Eric Chiou | Aerodigestive disorders, eosinophilic esophagitis, esophageal motility disorders, gastroesophageal reflux disease, motility |
| Bruno Chumpitazi | Diet, fermentable carbohydrates, gastroparesis, gut microbiome, irritable bowel syndrome |
| Douglas Fishman | Endoscopy, ERCP, pancreatitis, polyposis |
| Sanjiv Harpavat | Alagille syndrome, biliary atresia, neonatal cholestasis, newborn screening, Wilson disease |
| Paula Hertel | Biliary atresia, cholestasis, fatty liver disease, idiopathic neonatal cholestasis, progressive familial intrahepatic cholestasis |
| John Hollier | Constipation, failure to thrive, functional abdominal pain disorders, health disparities, irritable bowel syndrome |
| Faith Ihekweazu | Health equity, implicit bias, inflammatory bowel disease, microbiome, racial inequity |
| Richard Kellermayer | Environmental origins, epigenetics, inflammatory bowel disease, microbiome |
| Daniel Leung | Biomarkers, cystic fibrosis, liver fibrosis, pediatric transplant, viral hepatitis |
| Carmen Mikhail | Camp, childhood obesity, community, cognitive-behavioral therapy, predictors |
| Kathleen Motil | Gastrointestinal dysfunction, metabolome, microbiome, Rett syndrome |
| Krupa Mysore | Cholestasis, immune function, infections, liver transplantation, pediatric chronic liver disease |
| Anthony Olive | Eosinophilic gastrointestinal disorders |
| Geoffrey Preidis | Bile acids, gut microbiome, malnutrition, neonatal gastroenterology, neurogastroenterology and motility |
| Benjamin Shneider | Cholestasis, cirrhosis, clinical trials, intestinal cancer, portal hypertension |
| Robert Shulman | Abdominal pain, functional dyspepsia, gastroparesis, irritable bowel syndrome |
| Sundararajah Thevananther | Fatty liver disease, hepatocellular carcinoma, purinergic signaling, sepsis induced liver injury |
| Elizabeth Tessier | Biliary atresia, cholestasis, microbiome, primary sclerosing cholangitis |
| Lynette Van Buren | Intestinal failure, intestinal rehabilitation, short bowel syndrome, teduglutide, total parenteral nutrition |
Postdoctoral Research Opportunities
Postdoctoral research opportunities are available for both M.D. and Ph.D. candidates in the areas of basic science, translational biology or clinical research. Funding from an NIH Training Grant is available for competitive candidates who are U.S. citizens or permanent residents.