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STAR

Houston, Texas

Representation of several types of stem cells
STaR Center
not shown on screen

Mary Dickinson, Ph.D.

Mary Dickinson, Ph.D.Assistant Professor
Department of Molecular Physiology and Biophysics

Phone: 713-798-2104
Fax: 713-798-3475
E-mail: mdickins@bcm.edu

Education

  • Ph.D., Columbia University
  • Postdoctoral, Caltech

Research Interests

My laboratory uses a multi-disciplinary approach to study the role of fluid-derived mechanical forces in vascular remodeling and heart morphogenesis in early vertebrate embryos. We have recently developed methods for time-lapse, confocal imaging of rapid blood flow and heart mechanics using vital fluorescent protein reporters. With these methods we are studying the response to changes in mechanical stress in mouse and zebrafish models, taking advantage of the wealth of mutant animals.

Selected Publications

  • Liebling, M., Farouhar, A.S., Gharib, M., Fraser, S.E. and Dickinson, M.E. 4-Dimensional Cardiac Imaging of Living Embryos via Post-Acquisition Synchronization of Nongated Slice-Sequences. Journal of Biomedical Optics, in press.
  • Lucitti, J.L., Jones, E.A.V., Huang, C., Chen, J., Fraser, S.E. and Dickinson, M.E. (2007) Vascular Remodeling of the Yolk Sac Requires Hemodynamic Force, Development, 134: 3317-3326.
  • Larina, I.V., Wang, Y., Chien, S., Lane, M.E. and Dickinson, M.E. (2007) “On the way to subcellular imaging of mechanotransduction in the developing vasculature” in Optical Technologies in Biophysics and Medicine, Valery V. Tuchin, Editors, Proceedings of the International Society for Optical Engineering (SPIE) 6535:653504.
  • Dickinson, M.E. (2006) Multimodal Imaging of Mouse Development: Tools for the Postgenomic Era. Developmental Dynamics, 235: 2386-2400.
  • Lucitti, J.L. and Dickinson, M.E. (2006) Moving Towards the Light: Using New Technology to Answer Old Questions, Pediatr Res 60: 1–5.
  • Liebling, M, Forouhar, AS, Wolleschensky, R, Ankerhold, R, Zimmermann, B, Fraser, SE, Gharib, M and Dickinson, ME (2006) Rapid, Confocal Microscopy Reveals Functional Changes in Embryonic Heart Development, Developmental Dynamics, 235, 2940-2948.
  • Forouhar, AS, Hickerson, AS, Liebling, M, Moghaddam, A, Lu, J, Tsai, H-J, Hove, JR, Fraser, SE, Dickinson, ME, and Gharib, M (2006) The Embryonic Zebrafish Heart as a Resonance Suction Pump. Science, 312, 751-753
  • Wang, J, Hamblet, N.S, Mark, S, Dickinson, ME, Brinkman, BC, Segil, N, Fraser, SE, Chen, P, Wallingford, JB, Wynshaw-Boris, A (2006) Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development, 133, 1767-1778.
  • Liebling, M, Farouhar, AS, Gharib, M, Fraser, SE and Dickinson, ME (2005) 4-Dimensional Cardiac Imaging of Living Embryos via Post-Acquisition Synchronization of Nongated Slice-Sequences. Journal of Biomedical Optics, 10: 054001.
  • Fraser, S.T., Hadjantonakis, A-K., Sahr, K.E., Willey, S., Kelly, O.G., Jones, E.A.V., Dickinson, M.E. and Baron, M.H. (2005) Using a Histone Yellow Fluorescent Protein Fusion For Tracking Endothelial Cells in ES cells and Mice, Genesis, 42: 162-171.
  • Nashmi, R., Fraser, S.E., Lester, H.A and Dickinson , M.E . (2005) FRET Measurements using Multispectral Imaging. In, Protein Molecular Imaging: FRET Microscopy. Eds. Periasamy, A. and Day, R.N., Oxford, UK: Oxford University Press.
  • Jones, E.A.V., Hadjantonakis, A-K., and Dickinson, M.E. (2005) Imaging Mouse Embryonic Development. In, Imaging in Neuroscience and Development: A Laboratory Manual., Ed. Yuste, R.. New York: Cold Spring Harbor Laboratory Press.
  • Dickinson , M.E . Multiphoton, Multispectral Laser Scanning Microscopy. (2005) In,.Live Cell Imaging: A Laboratory Manual. Eds., Goldman, R.D. and Spector, D.S., New York: Cold Spring Harbor Laboratory Press.
  • Jones, E.A.V., Crotty, D., Baron, M.H., Fraser, S.E. and Dickinson, M.E. (2004) Dynamic In Vivo Imaging of Mammalian Hemato-Vascular Development Using Whole Embryo Culture. In, Developmental Regulation of Hematopoiesis: Methods and Protocols, ed. Baron, M.H., Methods in Molecular Medicine series. New York: Humana Press.
  • Jones, E.A.V., Baron, M.H., Fraser, S.E. and Dickinson, M.E. (2004) Hemodynamic Changes During the Development of the Mammalian Vasculature, Am J Phys Heart Circ Physiol, 287, 1561-1569.
  • Nashmi, R., Dickinson, M.E., McKinney, S., Jareb, M., Labarca, C., Fraser, S.E. and Lester, H.A.(2003) Localization, Trafficking and Resonance Energy Transfer in Functional Fluorescently Labeled alpa-4 beta-2 Nicotinic Acetylcholine Receptors. J. Neuroscience, 23 , 11554-11567.
  • Hadjantonakis, A-K, Dickinson, M.E, Fraser, S.E., and Papaioannou, V.E. (2003) Technicolour Transgenics: Imaging tools for functional genomics in the mouse. Nature Rev. Genet. 4, 613-625.
  • Dickinson , M.E . , Simbuerger, E., Zimmermann, B., Waters, C.W. and Fraser, S.E. (2003) Multiphoton Spectra in Biological Samples. Journal of Biomedical Optics, 8, 329-338.
  • Jones, E.A.V., Crotty, D., Kulesa, P.M., Waters, C.W., Baron, M.H., Fraser, S.E., Dickinson, M.E.(2002). Dynamic In Vivo Imaging of Post Implantation Mammalian Embryos Using Whole Embryo Culture. Genesis, 34: 228-35.

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