Rachel E. Rau, M.D.

Assistant Professor

(832) 822-1528

Email

rerau@bcm.edu

Positions

Assistant Professor: Pediatrics-Oncology
Baylor College of Medicine
Houston, TX, US

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Addresses

Texas Children's Hospital, Clinical Care Center (Clinic): 6701 Fannin St., 14th floor
Houston, TX, 77030
United States
Phone: (832) 822-4242

One Baylor Plaza (Lab): Alkek Bldg Rm N1030
Houston, TX, 77030
United States

TCH-Clinical Care Center (Office): Room: TXCL-151022
Houston, TX, 77030
United States

Education

Advanced Training from Johns Hopkins University: 01/2011 - Baltimore, MD, United States

Advanced Training from Johns Hopkins University School Of Medicine: 01/2008 - Baltimore, MD, United States

M.D. from Ohio State University College Of Medicine: 01/2003 - Columbus, OH, United States

B.A. from Case Western Reserve University: 01/1999 - Cleveland, OH, United States

Certifications

American Board of Pediatrics

American Board of Pediatrics, Pediatric Hematology and Oncology

Websites

VIICTR Publications List

Selected Publications

Rau, R., Yang, L., Goodell, M.A.. " DNMT3A in Hematologic Malignancy. " Nature Reviews Cancer. 2015 ;
Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P. " MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism. " Br. J. Haematol.. 2013 Mar ; 160 (6) : 785-97.
Pubmed PMID: 23294096.
Rau, R., Magoon, D., Greenblatt, S., Li, L., Pandolfi, PP., Small, DS., Brown, P.. " Mutated NPMc+ cooperates with FLT3/ITD mutations to cause leukemia recapitulating human disease. " Exper Hematol. 2014 Feb ;
Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens. " Cell Press J Chem & Biol. 2013 ;
Rau, R., Brown, P.. " Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity. " Hematol Oncol. 2009 ;
Plerixafor as a Chemosensitizing Agent in Pediatric ALL: Efficacy and Potential Mechanisms of Resistance to CXCR4 Inhibition. " ;
The incidence and clinical significance of nucleophosmin mutations in Childhood AML. " Blood. 2007 ;
Schafer ES, Rau RE, Liu X, Minard, CG, D’Adamo D, Scott R, Reyderman L, Martinez G, Fox E, Weigel BJ, Blaney SB. " A phase 1 study of eribulin mesylate (E7389), a novel microtubule targeting chemotherapeutic agent in children with refractory or recurrent solid tumors (excluding CNS), including lymphomas: a Children’s Oncology Group Phase 1 Consortium study (ADVL1314) " Pediatric Blood & Cancer. 2018 Aug ; 65 (8)
Pubmed PMID: 29719113.
Rau RE. " CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3 " Blood. 2017 Jul 27; 130 (4) : 385-386.
Pubmed PMID: 28751353.
Gramatges MM, Deshpande A, Lupo PJ, Rau RE, Redell ML, Horton TM, Scheurer ME, Rabin KR. " Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia " Pediatric Blood & Cancer. 2017 Sep ; 64 (9)
Pubmed PMID: 28266784.
Rau RE, Carroll AJ, Heerema NA, Arland L, Carroll WL, Winick NJ, Raetz EA, Loh ML, Yang W, Relling MV, Dai Y, Devidas M, Hunger SP. " Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukemia " Br J Heamatol. 2017 Dec ; 179 (5) : 843-846.
Pubmed PMID: 27434379.
Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DA, Brown P. " Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice " Oncotarget. 2018 Oct 19; 9 (82) : 35313-35326.
Pubmed PMID: 30450160.
Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME. " Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia " PLoS One. 2018 May 15; 13 (5)
Pubmed PMID: 29763473.
Rau RE, Goodell MA. " Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning. " Cell Stem Cell. 2019 Apr 4; 24 (4) : 511-512.
Pubmed PMID: 30951659.
Rau RE, Dreyer Z, Choi MR, Liang W, Skowronski R, Allamneni KP, Devidas M, Raetz EA, Adamson PC, Blaney SM, Loh ML, Hunger SP. " Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children’s Oncology Group " Pediatric Blood & Cancer. 2018 Mar ; 65 (3)
Pubmed PMID: 29090524.
Miller MB, Brackett J, Schafer ES, Rau RE. " Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites " Pediatr Blood Cancer.. 2019 Apr ; 66 (4)
Pubmed PMID: 30548777.
Rau RE, Luo M, Jeong M, Rodriguez B, Rosen A, Rogers J, Campbell C, Daigle S, Song Y, Sweet S, Chevassut T, Andreeff M, Li W, Goodell MA. " Targeting DOT1L for the treatment of DNMT3A mutant AML " Blood. 2016 Aug 18; 128 (7) : 971-81.
Pubmed PMID: 27335278.
Rau, RE and Loh ML. " Using genomics to define pediatric blood cancers and inform practice " Hematology Am Soc Hematol Educ Program. 2018 Nov 30; 2018 (1) : 286-300.
Pubmed PMID: 30504323.
Rau, RE. " Beyond KIT in CBF-AML: chromatin and cohesin " Blood. 2016 May 19; 127 (20) : 2370-1.
Pubmed PMID: 27207321.
Yang L, Rodriguez B, Mayle A, Park H-J, Lin X, Luo M, Jeong M, Curry CV, Kim S-B, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee J-S, Rau R, Li W, and Goodell MA. " DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias " Cancer Cell. 2016 Jun 13; 29 (6) : 922-934.
Pubmed PMID: 27505680.
Eckstein OS, Wang L, Punia JN, Kornblau S, Andreeff M, Wheeler DA, Goodell MA, Rau R. " Mixed phenotype acute leukemia (MPAL) has a high frequency of mutations in splicing and epigenetic regulatory genes " Exper Hematol. 2016 Aug ; 44 (8) : 740-744.
Pubmed PMID: 27208809.