Positions
- Assistant Professor
-
Pediatrics-Oncology
Baylor College of Medicine
Houston, TX US
- Member
-
Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas United States
Addresses
- TCH-Clinical Care Center (Office)
-
Room: TXCL-151022
Houston, TX 77030
United States
- One Baylor Plaza (Lab)
-
Alkek Bldg Rm N1030
Houston, TX 77030
United States
- Texas Children's Hospital, Clinical Care Center (Clinic)
-
6701 Fannin St., 14th floor
Houston, TX 77030
United States
Phone: (832) 822-4242
Education
- Advanced Training from Johns Hopkins University
- 01/2011 - Baltimore, MD United States
- Advanced Training from Johns Hopkins University School Of Medicine
- 01/2008 - Baltimore, MD United States
- M.D. from Ohio State University College Of Medicine
- 01/2003 - Columbus, OH United States
- B.A. from Case Western Reserve University
- 01/1999 - Cleveland, OH United States
Certifications
- American Board of Pediatrics
- American Board of Pediatrics, Pediatric Hematology and Oncology
Websites
Selected Publications
- Rau, R., Yang, L., Goodell, M.A. "DNMT3A in Hematologic Malignancy." Nature Reviews Cancer. 2015;
- Sison EA, Rau RE, McIntyre E, Li L, Small D, Brown P "MLL-rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism.." Br. J. Haematol.. 2013 Mar;160(6):785-97. Pubmed PMID: 23294096
- Rau, R., Magoon, D., Greenblatt, S., Li, L., Pandolfi, PP., Small, DS., Brown, P. "Mutated NPMc+ cooperates with FLT3/ITD mutations to cause leukemia recapitulating human disease." Exper Hematol. 2014 Feb;
- "Next-generation NAMPT inhibitors identified by sequential high-throughput phenotypic chemical and functional genomic screens." Cell Press J Chem & Biol. 2013;
- Rau, R., Brown, P. "Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity." Hematol Oncol. 2009;
- "Plerixafor as a Chemosensitizing Agent in Pediatric ALL: Efficacy and Potential Mechanisms of Resistance to CXCR4 Inhibition." ;
- "The incidence and clinical significance of nucleophosmin mutations in Childhood AML." Blood. 2007;
- Schafer ES, Rau RE, Liu X, Minard, CG, D’Adamo D, Scott R, Reyderman L, Martinez G, Fox E, Weigel BJ, Blaney SB "A phase 1 study of eribulin mesylate (E7389), a novel microtubule targeting chemotherapeutic agent in children with refractory or recurrent solid tumors (excluding CNS), including lymphomas: a Children’s Oncology Group Phase 1 Consortium study (ADVL1314)." Pediatric Blood & Cancer. 2018 Aug;65(8) Pubmed PMID: 29719113
- Rau RE "CMML/JMML PDXs: as easy as 1, 2, NSG-SGM3." Blood. 2017 Jul 27;130(4):385-386. Pubmed PMID: 28751353
- Gramatges MM, Deshpande A, Lupo PJ, Rau RE, Redell ML, Horton TM, Scheurer ME, Rabin KR "Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia." Pediatric Blood & Cancer. 2017 Sep;64(9) Pubmed PMID: 28266784
- Rau RE, Carroll AJ, Heerema NA, Arland L, Carroll WL, Winick NJ, Raetz EA, Loh ML, Yang W, Relling MV, Dai Y, Devidas M, Hunger SP "Klinefelter syndrome and 47,XYY syndrome in children with B cell acute lymphoblastic leukemia." Br J Heamatol. 2017 Dec;179(5):843-846. Pubmed PMID: 27434379
- Annesley CE, Rabik C, Duffield AS, Rau RE, Magoon D, Li L, Huff V, Small D, Loeb DA, Brown P "Knock-in of the Wt1 R394W mutation causes MDS and cooperates with Flt3/ITD to drive aggressive myeloid neoplasms in mice." Oncotarget. 2018 Oct 19;9(82):35313-35326. Pubmed PMID: 30450160
- Schraw JM, Yiu TT, Lupo PJ, Tsavachidis S, Rau R, Bondy ML, Rabin KR, Shen L, Scheurer ME "Maternal folate genes and aberrant DNA hypermethylation in pediatric acute lymphoblastic leukemia." PLoS One. 2018 May 15;13(5) Pubmed PMID: 29763473
- Rau RE, Goodell MA "Measure Twice, Cut Once: Therapeutic Editing of HSPCs Requires Precise Planning.." Cell Stem Cell. 2019 Apr 4;24(4):511-512. Pubmed PMID: 30951659
- Rau RE, Dreyer Z, Choi MR, Liang W, Skowronski R, Allamneni KP, Devidas M, Raetz EA, Adamson PC, Blaney SM, Loh ML, Hunger SP "Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children’s Oncology Group." Pediatric Blood & Cancer. 2018 Mar;65(3) Pubmed PMID: 29090524
- Miller MB, Brackett J, Schafer ES, Rau RE "Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites." Pediatr Blood Cancer.. 2019 Apr;66(4) Pubmed PMID: 30548777
- Rau RE, Luo M, Jeong M, Rodriguez B, Rosen A, Rogers J, Campbell C, Daigle S, Song Y, Sweet S, Chevassut T, Andreeff M, Li W, Goodell MA "Targeting DOT1L for the treatment of DNMT3A mutant AML." Blood. 2016 Aug 18;128(7):971-81. Pubmed PMID: 27335278
- Rau, RE and Loh ML "Using genomics to define pediatric blood cancers and inform practice." Hematology Am Soc Hematol Educ Program. 2018 Nov 30;2018(1):286-300. Pubmed PMID: 30504323
- Rau, RE "Beyond KIT in CBF-AML: chromatin and cohesin." Blood. 2016 May 19;127(20):2370-1. Pubmed PMID: 27207321
- Yang L, Rodriguez B, Mayle A, Park H-J, Lin X, Luo M, Jeong M, Curry CV, Kim S-B, Ruau D, Zhang X, Zhou T, Zhou M, Rebel VI, Challen GA, Gottgens B, Lee J-S, Rau R, Li W, and Goodell MA "DNMT3A loss drives enhancer hypomethylation in FLT3-ITD-associated leukemias." Cancer Cell. 2016 Jun 13;29(6):922-934. Pubmed PMID: 27505680
- Eckstein OS, Wang L, Punia JN, Kornblau S, Andreeff M, Wheeler DA, Goodell MA, Rau R "Mixed phenotype acute leukemia (MPAL) has a high frequency of mutations in splicing and epigenetic regulatory genes." Exper Hematol. 2016 Aug;44(8):740-744. Pubmed PMID: 27208809
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