Margaret A. Goodell, Ph.D.
Director, STaR Center
Associate Professor, Baylor College of Medicine
Center for Cell & Gene Therapy
One Baylor Plaza, Room N1030
Houston, TX 77030
Professor, Department of Pediatrics; Programs in Integrative Molecular and Biomedical Sciences; Developmental Biology; and Translational Biology & Molecular Medicine; Center for Cell and Gene Therapy; Stem Cells and Regenerative Medicine (STaR) Center
B.S., Imperial College of Science and Technology, London, England, 1986
Ph.D., University of Cambridge, England, 1991
Postdoc, Whitehead Institute, Massachusetts Institute of Technology, 1996
Postdoc, Harvard Medical School, Boston, MA, 1997
Hematopoietic Stem Cells
Murine and human hematopoietic stem cells; genetic and epigenetic regulation and development.
We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.
- Zohren F, Souroullas GP, Luo M, Gerdemann U, Imperato MR, Wilson NK, Göttgens B, Lukov GL, Goodell MA (2012). The transcription factor Lyl-1 regulates lymphoid specification and the maintenance of early T lineage progenitors. Nat. Immunol. 13(8): 761-9. PubMed PMID:22772404
- Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA (2011). Dnmt3a is essential for hematopoietic stem cell differentiation. Nat. Genet. 44(1): 23-31. PubMed PMID: 22138693
- Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA (2010). Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature 465(7299): 793-7. PubMed PMID: 20535209
- Challen GA, Boles NC, Chambers SM, Goodell MA (2010). Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1. Cell Stem Cell 6(3): 265-78. PubMed PMID:20207229