Targeting the Inflammasome to Prevent Thoracic Aortic Aneurysms and Dissections

The overall objective of this project is to systematically define the role of the NLRP3 inflammasome cascade, a multiprotein platform involved in amplifying intracellular stress responses, in promoting aortic destruction, and to determine the extent to which this cascade represents a therapeutic target against aortic aneurysms and dissections.

This project is currently supported by NIH NHLBI R56 and R01 awards. R56 HL127111 and R01 HL127111 respectively.

Targeting ER Stress to Treat Thoracic Aortic Aneurysms and Dissections

The objectives of this project are to determine the role of endoplasmic reticulum stress and the endoplasmic reticulum stress sensor STING in aortic destruction, and the extent to which this mechanism represents a therapeutic target against aortic aneurysms and dissections.

This project is currently supported by an NIH NHLBI R01 award. R01 HL131980

Destructive Role of ADAMTS-4 in Aortic Aneurysms and Dissections

The goal of this project is to determine the role of ADAMTS-4 in aortic destruction and dysfunction and evaluate the effect of ADAMTS-4 inhibitors in prevention and treatment of aortic disease.

This project is currently supported by an American Heart Association Grant-in-Aid. 15GRNT23040007