Center for Medical Ethics and Health Policy

Promoting High-Quality Ethics Review and Oversight of Psychedelic Research: Learning from Investigator Experience and IRB Perspectives


Amid today’s psychedelic renaissance, more IRBs will find themselves responsible for oversight of psychedelic research. In this gatekeeping role, IRBs must ensure appropriate participant protection without inhibiting important science. Yet neither IRB perspectives on psychedelic research nor psychedelic investigator experiences with IRBs have been studied. Through qualitative interviews with psychedelic investigators and a survey of IRB chairpersons, this project aims to promote high-quality ethics review of psychedelic research by developing empirically informed resources for both IRBs and investigators.

Funded by: The Greenwall Foundation


Project Personnel

  • Holly Fernandez Lynch, PI, University of Pennsylvania Perelman School of Medicine
  • Dominic Sisti, Co-I, University of Pennsylvania Perelman School of Medicine
  • Amy McGuire, Co-I
  • Logan Neitzke-Spruill, Post-doctoral associate 



McGuire AL, Lynch HF, Grossman LA, Cohen IG. Pressing regulatory challenges for psychedelic medicine. Science. 2023 Apr 28;380(6643):347-350. doi: 10.1126/science.adg1324. Epub 2023 Apr 27. PMID: 37104606.