Join us in investigating the importance of interactions between microbes, their hosts and the immune system in human health and disease.

As a student in the Immunology & Microbiology Graduate Program at Baylor College of Medicine, you will receive a personalized, inquiry-based education and actively acquire a sophisticated understanding of basic and translational immunology and microbiology problems and state-of-the-art techniques.  We also emphasize the development of critical thinking, creativity, and problem-solving skills necessary for diverse scientific careers. Our interdisciplinary faculty members have diverse research interests that span many aspects of basic, translational, and clinical immunology and microbiology.  This broad spectrum of topics provides rich opportunities for collaborative and interdisciplinary thesis projects at the cutting-edge of training in these fields.

2016 Annual Retreat (372x158)

Diverse Perspectives

Our program draws together faculty members with shared interests in immunology and microbiology to provide a diversity of scientific perspectives. 

Britton lab 070215 (372x158)

Where will your Ph.D. take you?

Our graduates have gone on to build successful careers in academia, industry, law, consulting and more. Whatever your vision for your career entails, we will provide the training, resources and support to help you realize your ambition. 

Immunology & Microbiology News

credit: National Human Genome Research Institute
Team work and balance can keep a gut healthy

A significant body of work currently is indicating that the microbiota helps shape the immune system and allows it to do its job. BCM researchers are investigating the role the microbiota plays in modulating the immune response in a way that reduces the damage inflammation can do to the gut.

credit: Usman Bashir/Creative Commons
The social amoeba’s surviving balancing act

Single-celled bodies of the social amoeba Dictyostelium discoideum live in the soil voraciously feeding on bacteria. As this food source dwindles, the amoebas get stressed and respond by getting together, forming first a slug and then a fruiting body consisting of a ball of spores balanced atop a dead stalk. It’s been known for a number of years that the multicellular slug and the fruiting body stages of some, but not all, social amoeba carry bacteria. BCM researchers are investigating how some amoebas manage to maintain their own microbiome and, at the same time, keep an innate defense mechanism that should kill the bacteria.

credit: National Human Genome Research Institute, NIH/Jonathan Bailey
Gut metabolite profile may provide insight into how NEC happens

Necrotizing enterocolitis (NEC) is a serious disease mediated by an inflammatory process that leads to intestinal damage and sometimes death. The risk of preterm infants developing the disease also is higher when they are fed formula than when they feed on breast milk. In this study, the researchers took a closer look at the effect of two different sugars on the development of NEC using a detailed analysis: they characterized the bacterial communities, or microbiome, of the gut, and the metabolite profiles found in the gut and the blood.

Heart NLRP3 inflammasome linked to atrial fibrillation

Atrial fibrillation is the most common heart arrhythmia that can increase a person’s risks for stroke and related heart problems. BCM researchers set out to determine whether inflammatory signaling could be playing a causative role in atrial fibrillation. They found that the activation of an inflammasome pathway in heart cells can affect many proteins that are involved in modulating the electrophysiology of cardiac cells. Enhancing this pathway ultimately leads to abnormal electrical patterns that are similar to those observed in atrial fibrillation in the mouse model.

David vs Goliath: how a small molecule can defeat asthma attacks

Corry’s laboratory has been studying asthma for about 20 years. One of their interests is to better understand the molecular pathways that drive airway constriction.

credit: National Cancer Institute
Fighting back lymphoma resistance to treatment

BCM researchers genetically modified tumor-directed T cells so they cannot be affected by the inhibitory TGFβ signals of the tumor environment. They worked with T cells specifically directed at lymphoma caused by Epstein-Barr virus (EBV).

credit: National Human Genome Institute/ Darryl Leja
Friend and foe: Histamine mediates allergies and can fight colorectal cancer

Previous studies have shown that histamine is not only involved in allergic disease, it also may have a potential antitumor effect. BCM researchers investigated whether the probiotic Lactobacillus reuteri 6475, which is able to generate histamine, had the ability to reduce the frequency and severity of inflammation-associated colorectal cancer in mice that were not able to produce histamine on their own.

A closer look at how elephants fight herpesvirus

For the first time, researchers at Baylor College of Medicine have been able to identify T cell immune responses directed against EEHV, and this could be the first steps in developing an effective vaccine for this deadly disease.

From the Labs to Commercialization: the Estes lab and ImmuCell Success Story

After more than 20 years of research, discoveries from a BCM lab successfully resulted in a vaccine against rotavirus, triggered the interest of an industry partner, ImmuCell, and were ultimately developed into a final product that has been approved and is available for use in the U.S.

From the Labs

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