June 11, 2021 − Virtual Workshop
8 a.m. − 12 p.m. via Zoom
Residents, fellows and faculty interested in performing systematic reviews of diagnostic tests
- Understand the clinical relevance of diagnostic tests
- Develop a roadmap for assembling a systematic review of diagnostic tests
Mohan Pammi, M.D., Ph.D., MRCPCH
From the Evidence Academy at Texas Children's Hospital
Ganga Gokulakrishnan, Aarti Bavare, Krithika Lingappan, Nirica Borges, Melissa Carbajal
A diagnostic test accuracy study provides evidence on how well a test correctly identifies or rules out disease and informs subsequent decisions about treatment for clinicians, their patients, and healthcare providers.
A systematic review of diagnostic test accuracy summarizes results from diagnostic studies, also investigates why the results may vary among studies, compare the performance of alternative tests, and help the reader to put the evidence in a clinical context.
This workshop will enable learners to develop a roadmap for performing a systematic review of diagnostic tests using Cochrane methodology. The session will lead learners through each of the steps of creation of a protocol and systematic review. Knowledge and skills imparted will relate to formulating the clinical question in PICOT format (Population, Intervention, Comparators, Outcomes and Trial design), crystallizing the objectives of the review, developing a comprehensive search strategy, identifying studies eligible for inclusion in the review using the PRISMA flow diagram, appraising the evidence using accepted methods for evaluating risk of bias, extract data and perform analysis and meta-analysis of relevant data. Participants will learn to present results in summary findings tables, rate the quality of evidence using ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and derive conclusions for clinical practice and research. The workshop will close with a question and answer session and discussion of ideas for participants to perform systematic reviews at their home institutions.
Who Should Participate?
Faculty and trainees at any stage in their career who are interested in learning the principles and practice of evidence-based medicine.
Diagnostic Tests And Systematic Reviews On Diagnostic Tests
June 11, 2021, 8 a.m. - 12 p.m.
1. Introduction and brief overview of the course (8 - 8:15 a.m.)
Lead faculty - Mohan Pammi, Ganga Gokulakrishnan and Nirica Borges - 15 minutes
2. Role of diagnostic tests in evidence-based practice (8:15 - 8:45 a.m.)
Lead faculty – Roger Soll – 30 minutes
3. Diagnostic tests’ attributes and clinical relevance (8:45 - 9:30 a.m.)
Lead faculty – Prakesh Shah - 45 minutes
Break - 10 minutes
4. Systematic reviews of diagnostic test accuracy and the Cochrane DTA review process (9:40 - 10:20 a.m.)
Lead faculty – Mariska Leeflang - 40 minutes
5. Appraisal of diagnostic test accuracy studies (10:20 - 10:50 a.m.)
Lead faculty- Mohan Pammi- 30 minutes
6. Meta-analysis of diagnostic test accuracy studies (10:50 - 11:30 a.m.)
Lead faculty - Yemisi Takwoingi - 45 minutes
7. Story of how we did a diagnostic test accuracy systematic review (11:30 - 11:50 p.m.)
8. Closure and questions
11:50 - noon