Department of Pediatrics

Systematic Reviews Workshop

Master
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Registration

Content

Registration is now closed.

Dec. 2, 2020 − Virtual Workshop
9 a.m. − 12 p.m. via Zoom

Target audience
Residents, fellows and faculty interested in performing systematic reviews

Objectives

  1. Design a protocol for a systematic review of intervention.
  2. Assemble a systematic review in Revman software and perform meta-analysis.

Course director
Mohan Pammi, M.D., Ph.D., MRCPCH

From the Evidence Academy at Texas Children's Hospital
Ganga Gokulakrishnan, Aarti Bavare, Krithika Lingappan, Nirica Borges, Melissa Carbajal

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Course Faculty

Terms

Roger F. Soll, M.D.

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Professor, University of Vermont, Coordinating Editor of Cochrane Neonatal Review Group, and President of Vermont Oxford Network

Prakesh Shah, M.D., MSc, M.B.B.S.

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Professor, Pediatrician-in-Chief, University of Toronto and Editor, Cochrane Neonatal Review Group

Mohan Pammi, M.D., Ph.D., MRCPCH

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Associate Professor, Section of Neonatology, Baylor College of Medicine and Texas Children's Hospital and Associate Editor, Cochrane Neonatal Review Group

Ganga Gokulakrishnan, M.B.B.S.

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Assistant Professor, Section of Neonatology, Baylor College of Medicine and Texas Children's Hospital

Nirica Borges, M.D., FAAP, CMQ

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Assistant Professor, Pediatrics-Critical Care, Baylor College of Medicine

Content

Systematic reviews comprise the highest level in the hierarchy of evidence to inform clinical practice. Authors of systematic reviews first generate a protocol with the relevant clinical question, specify objectives, delineate the search strategy to identify all relevant publications and prespecify methodology of the review and meta-analysis, ‘a priori’. Once the protocol is registered with Cochrane or other registries, the review is performed first searching for studies that are eligible for inclusion and performing critical appraisal of included studies. A systematic review may be performed with only qualitative synthesis when meta-analysis, the statistical synthesis of data is not appropriate. Retrieving, appraising and synthesizing literature fulfills ACGME core competencies of patient care, medical knowledge and practice-based learning and promotes educational scholarship.

This workshop will enable learners to develop a roadmap for performing a systematic review using Cochrane methodology. The session will lead learners through each of the steps of creation of a protocol and systematic review. Knowledge and skills imparted will relate to formulating the clinical question in PICOT format (Population, Intervention, Comparators, Outcomes and Trial design), crystallizing the objectives of the review, developing a comprehensive search strategy, identifying studies eligible for inclusion in the review using the PRISMA flow diagram, appraising the evidence using accepted methods for evaluating risk of bias, extract data and perform analysis and meta-analysis of relevant data. Participants will learn to present results in summary findings tables, rate the quality of evidence using ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and derive conclusions for clinical practice and research. The workshop will close with a question and answer session and discussion of ideas for participants to perform systematic reviews at their home institutions.

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Who Should Participate?

Content

Faculty and trainees at any stage in their career who are interested in learning the principles and practice of evidence-based medicine.

Content
Final Agenda for the Systematic Review Workshop

Time

Content

Teaching Method

Facilitator

10 minutes

Welcome, faculty introductions,
zoom orientation

Large group discussion

Mohan Pammi/Nirica Borges

15 minutes

A roadmap for performing systematic reviews, formulating the PICOT question and stating the review objectives

Didactic with zoom poll/annotation

Roger Soll

15 minutes

Formulate the PICOT question and objectives for a systematic review

Handouts with sample scenarios for PICOT questions

Zoom break out session for 5groups

20 minutes

VIDEO: Develop search strategy for different databases

Didactic

Ganga Gokulakrishnan, NiricaBorges,
Amy Sissons (librarian)

10 minutes

Q & A
Develop search strategy and search databases

Handouts
Discussion

 

 

 

Bio break-10 minutes

 

15 minutes

Appraise studies and risk of bias in included studies

Didactic/ARS

Prakesh S Shah

15 minutes

Appraise studies and risk of bias in included studies

Small group activity
Handouts of a study

 
Zoom break out session

5 minutes

Get back questions and discussion

 

 

30 minutes

Data extraction from included studies, data entry into Revman and analysis
Concurrent session/demonstration

Didactic

Mohan Pammi

 

 

Bio break-10 minutes

 

20 minutes

GRADE approach to rate certainty of evidence

Didactic

Roger Soll

10 minutes

GRADE certainty of evidence using examples of outcomes

Small group activity

Zoom break out session with 5groups

10 minutes

Discussion

 

 

20 minutes

Results, discussion and conclusions

 

Large group interactive session

Roger Soll
and all facilitators