!

COVID-19 Response 

Access our COVID-19 Response homepage, with more information and resources during the COVID-19 pandemic, including what to do if you’re experiencing symptoms.

Department of Pediatrics

Systematic Reviews Workshop

Master
Heading

Registration Now Open

Content

Dec. 2, 2020 − Virtual Workshop

Target audience
Residents, fellows and faculty interested in performing systematic reviews

Objectives

  1. Design a protocol for a systematic review of intervention.
  2. Assemble a systematic review in Revman software and perform meta-analysis.

Course director
Mohan Pammi, M.D., Ph.D., MRCPCH

From the Evidence Academy at Texas Children's Hospital
Ganga Gokulakrishnan, Aarti Bavare, Krithika Lingappan, Nirica Borges, Melissa Carbajal

 

Heading

Course Faculty

Terms

Roger F. Soll, M.D.

Item Definition

Professor, University of Vermont, Coordinating Editor of Cochrane Neonatal Review Group, and President of Vermont Oxford Network

Prakesh Shah, M.D., MSc, M.B.B.S.

Item Definition

Professor, Pediatrician-in-Chief, University of Toronto and Editor, Cochrane Neonatal Review Group

Mohan Pammi, M.D., Ph.D., MRCPCH

Item Definition

Associate Professor, Section of Neonatology, Baylor College of Medicine and Texas Children's Hospital and Associate Editor, Cochrane Neonatal Review Group

Ganga Gokulakrishnan, M.B.B.S.

Item Definition

Assistant Professor, Section of Neonatology, Baylor College of Medicine and Texas Children's Hospital

Nirica Borges, M.D., FAAP, CMQ

Item Definition

Assistant Professor, Pediatrics-Critical Care, Baylor College of Medicine

Content

Systematic reviews comprise the highest level in the hierarchy of evidence to inform clinical practice. Authors of systematic reviews first generate a protocol with the relevant clinical question, specify objectives, delineate the search strategy to identify all relevant publications and prespecify methodology of the review and meta-analysis, ‘a priori’. Once the protocol is registered with Cochrane or other registries, the review is performed first searching for studies that are eligible for inclusion and performing critical appraisal of included studies. A systematic review may be performed with only qualitative synthesis when meta-analysis, the statistical synthesis of data is not appropriate. Retrieving, appraising and synthesizing literature fulfills ACGME core competencies of patient care, medical knowledge and practice-based learning and promotes educational scholarship.

This workshop will enable learners to develop a roadmap for performing a systematic review using Cochrane methodology. The session will lead learners through each of the steps of creation of a protocol and systematic review. Knowledge and skills imparted will relate to formulating the clinical question in PICOT format (Population, Intervention, Comparators, Outcomes and Trial design), crystallizing the objectives of the review, developing a comprehensive search strategy, identifying studies eligible for inclusion in the review using the PRISMA flow diagram, appraising the evidence using accepted methods for evaluating risk of bias, extract data and perform analysis and meta-analysis of relevant data. Participants will learn to present results in summary findings tables, rate the quality of evidence using ‘Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach and derive conclusions for clinical practice and research. The workshop will close with a question and answer session and discussion of ideas for participants to perform systematic reviews at their home institutions.

 

Heading

Who Should Participate?

Content

Faculty and trainees at any stage in their career who are interested in learning the principles and practice of evidence-based medicine.

Heading

Time

Content

9 a.m. − 12 p.m. via Zoom

Free registration

Content
Tentative Agenda

Time

Content

Teaching Method

Objectives

Facilitator

10 min.

Welcome, introductions, icebreaker and review workshop agenda

Interactive

Identify the diversity of the audience and the current state of knowledge regarding systematic reviews- Objective 1

Mohan Pammi/Roger Soll/Prakesh S Shah

20 min.

A roadmap for performing systematic reviews, formulating the PICOT question and stating the review objectives

Didactic/ Audience response system (ARS)/poll everywhere

Develop a roadmap for a protocol- Objective 1

Roger Soll

10 min.

Formulate the PICOT question and objectives for a systematic review

Pair and Share
Handouts

 

Objective 1. In a pair, write a PICOT question and objectives for a review you would like to do. Discuss with your neighbor


We can think about Zoom break out rooms, may be five participants each

 

20 min.

Develop search strategy and search databases

Didactic

Objectives 1 and 2

Ganga Gokulakrishnan

10 min.

Develop search strategy and search databases

Small group activity
Handouts

 

Work as a group in developing a search strategy. Search at least 2 databases

Zoom break out rooms with five participants each

20 min.

Appraise studies and risk of bias in included studies

Didactic/ARS

Objective 2

Prakesh S. Shah

10 min.

Appraise studies and risk of bias in included studies

Small group activity
Handouts of a study

 

Objective 2
Work as a group to appraise risk of bias

 

Zoom break out rooms with five participants each

20 min.

Data extraction from included studies, data entry into Revman and analysis

Didactic

Objective 2

Mohan Pammi

10 min.

Data extraction from included studies, data entry into Revman and analysis

Small group activity
Example given in a handout

 

Objective 2
Work as a group for data extraction and entry into Revman for analysis

 

Zoom break out rooms with five participants each

20 min.

GRADE approach to rate certainty of evidence

Didactic

Objective 2

Roger Soll

10 min.

GRADE certainty of evidence using examples of outcomes

Small group activity

Objective 2

Zoom break out rooms with five participants each

20 min.

Discuss results, discussion and conclusions

Large group interactive session

Summarize the roadmap in performing a systematic review.

Development of an action plan for individual reviewers to work at their home institutions

Point to resources that assist in performing a systematic review

 

Roger Soll/Prakeshkumar Shah/Mohan Pammi