The following is a list of basic science research by investigator within the Section of Hematology and Oncology.
Malcolm K. Brenner, M.D., Ph.D.
- Gene transfer to augment the immune response to human tumors
- Effects of CD45 monoclonal antibodies on normal and malignant hemopoiesis
- Hodgkin and non-Hodgkin lymphoma, CLL
- Breast cancer oncology
- Breast cancer genomics
- Metastatic breast cancer
- Clinical trials
- Hypersensitive estrogen receptor in premalignant breast
Helen E. Heslop, M.D., M.B.,Ch.B.
- Translational research focusing on adoptive immunotherapy with gene-modified effector cells, to improve hemopoietic stem cell transplantation and cancer therapy
- Developmental biology of the mammary gland as it relates to both normal breast function and breast cancer progression
- Role of hedgehog signal transduction in mammary gland development and breast cancer using the mouse as a model organism
- Epidemiological research to prevent and treat cancer-associated thrombosis and thrombotic microangiopathy
- Clinical trials
- Define the multiple mechanisms by which the EDG family LPA receptors promote cancer invasion, metastasis, and inflammatory responses through G protein-independent signaling, and to verify these effects in vivo
- Cancer cell cycle
- Gene expression and regulation
- DNA damage response
Nicholas Mitsiades, M.D., Ph.D.
- Exploring and targeting the mechanisms involved in hormonal regulation of cancer (in particular of prostate cancer by androgen, and of breast cancer by estrogen)
- Identifying clinically applicable inhibitors of the expression and/or function of steroid receptor coactivators
- Investigating the mechanisms involved in the anticancer activity of the diabetes drug metformin and the lipid-lowering drugs HMG-CoA reductase inhibitors (statins)
- Targeting the signaling pathways triggered by somatic mutations in the G protein α subunits Gαq and Gα11 (encoded by the genes GNAQ and GNA11, respectively) in uveal melanomas
- Exploring novel therapies for thyroid cancer
- Molecular mechanisms for hormonal resistance in breast cancer: growth factor signaling pathways, phosphorylation of estrogen receptor, and interaction with receptor coregulators
- Molecular profiling of breast cancers for the identification of prognostic markers to individualize treatment and for the identification of new molecular targets for prevention and treatment
- Mechanisms of endocrine resistance in breast cancer
- Gene therapy for the prevention and treatment of breast cancer
- The study of cancer progenitor cells
- The properties of mesenchymal stromal cells, a population of non-hematopoietic, fibroblast-like cells that have been isolated from bone marrow
- Management of breast cancer
- Clinical Trials in breast cancer
- Neoadjuvant therapy
- Targeted therapy and biomarkers in breast cancer.
- HER2-positive breast cancer
- Prostate cancer
- Genitourinary cancers