The following are research studies conducted by individual investigators.
Malcolm K. Brenner, M.D., Ph.D.
- Activity of lymphotactin in childhood malignancy
- Treatment of Hodgkin's disease with gene marked cytotoxic T lymphocytes
- Cytotoxic T Cell transfer for therapy of EBV lymphoma
- Effects of CD45 monoclonal antibodies on normal and malignant hemopoiesis
- Therapeutic effects of CD 40L in acute lymphoblastic leukemia
- Pilot study of allogeneic stem cell transplantation with submyeloablative conditioning therapy for hematological diseases
- High-dose chemotherapy for Stage II/III breast cancer without stem cell rescue
Helen E. Heslop, M.D., M.B.,Ch.B.
- Immunotherapy with EBV-specific CTLs for EBV-positive Hodgkin's disease
- Immunotherapy with EBV-specific CTLs for nasopharyngeal cancer
- Immunotherapy with EBV-specific CTLs for PTLD
- Augmenting antiviral and anti-tumor immunity after hemopoietic stem cell transplants
Clinical research nurses for Dr. Heslop:
Goley Richardson, (713) 441-1038
Susan Feliciano, (713) 394-6942
Martha Pritchett Mims, M.D., Ph.D.
Investigator on multiple cancer clinical trials at the Michael E. DeBakey VA Medical Center and at Ben Taub Hospital. View a list of currently open cancer-related clinical trials.
For more information on studies done at the VA, contact research associates Teresa Joe at (713) 791-1414, ext. 25225, or Tiffany Perry at (713) 791-1414, ext. 24667.
Nicholas Mitsiades, M.D.
- Exploring and targeting the mechanisms involved in hormonal regulation of cancer (in particular of prostate cancer by androgen, and of breast cancer by estrogen)
- Identifying clinically applicable inhibitors of the expression and/or function of steroid receptor coactivators
- Investigating the mechanisms involved in the anticancer activity of the diabetes drug metformin and the lipid-lowering drugs HMG-CoA reductase inhibitors (statins)
- Targeting the signaling pathways triggered by somatic mutations in the G protein α subunits Gαq and Gα11 (encoded by the genes GNAQ and GNA11, respectively) in uveal melanomas
- Exploring novel therapies for thyroid cancer
- Biology and genetics of colorectal cancer, particularly young-onset colorectal cancer
- Disparities in access to cancer care by race/ethnicity and socioeconomic status
- Novel treatment strategies for pancreatic cancer
- Biology, diagnosis, prognostic factors, prevention and treatment of breast cancer