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Department of Medicine

Basic Science Research


The following is a list of basic science research by investigator within the section.


Malcolm K. Brenner, M.D., Ph.D.

  • Gene transfer to augment the immune response to human tumors
  • Effects of CD45 monoclonal antibodies on normal and malignant hemopoiesis

Suzanne A.W. Fuqua, Ph.D.

  • Hypersensitive estrogen receptor in premalignant breast

Helen E. Heslop, M.D., M.B.,Ch.B.

  • Translational research focusing on adoptive immunotherapy with gene-modified effector cells, to improve hemopoietic stem cell transplantation and cancer therapy

Michael T. Lewis, Ph.D.

  • Developmental biology of the mammary gland as it relates to both normal breast function and breast cancer progression
  • Role of hedgehog signal transduction in mammary gland development and breast cancer using the mouse as a model organism

Fang-Tsyr Lin, M.D., Ph.D.

  • Define the multiple mechanisms by which the EDG family LPA receptors promote cancer invasion, metastasis and inflammatory responses through G protein-independent signalling, and to verify these effects in vivo.

Weei-Chin Lin, M.D., Ph.D.

  • Cancer cell cycle
  • Gene expression and regulation
  • DNA damage response

Nicholas Mitsiades, M.D., Ph.D.

  • Exploring and targeting the mechanisms involved in hormonal regulation of cancer (in particular of prostate cancer by androgen, and of breast cancer by estrogen)
  • Identifying clinically applicable inhibitors of the expression and/or function of steroid receptor coactivators
  • Investigating the mechanisms involved in the anticancer activity of the diabetes drug metformin and the lipid-lowering drugs HMG-CoA reductase inhibitors (statins)
  • Targeting the signaling pathways triggered by somatic mutations in the G protein α subunits Gαq and Gα11 (encoded by the genes GNAQ and GNA11, respectively) in uveal melanomas
  • Exploring novel therapies for thyroid cancer

C. Kent Osborne, M.D.

  • Molecular mechanisms for hormonal resistance in breast cancer: growth factor signaling pathways, phosphorylation of estrogen receptor, and interaction with receptor coregulators
  • Molecular profiling of breast cancers for the identification of prognostic markers to individualize treatment and for the identification of new molecular targets for prevention and treatment
  • Mechanisms of endocrine resistance in breast cancer
  • Gene therapy for the prevention and treatment of breast cancer

Carlos Almeida Ramos, M.D.

  • The study of cancer progenitor cells
  • The properties of mesenchymal stromal cells, a population of non-hematopoietic, fibroblast-like cells that has been isolated from bone marrow