Matthew William Grol, Ph.D.
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Matthew William Grol, Ph.D.
Instructor
Positions
- Instructor
-
Molecular and Human Genetics
Baylor College of Medicine
Houston, Texas United States
Addresses
- Alkek Building for Biomedical Research (Lab)
-
Room: ABBR-R830
Houston, TX 77030
United States
- Alkek Building for Biomedical Research (Office)
-
Room: ABBR-R830
Houston, TX 77030
United States
Education
- Ph.D. from The University of Western Ontario
- 11/2013 - London, Ontario Canada
- Cell Biology, Physiology
- B.M.Sc. from The University of Western Ontario
- 06/2007 - London, Ontario Canada
- Biochemistry, Cell Biology
Honors & Awards
- CIHR Fellowship
- Canadian Institutes of Health Research (CIHR) (07/2014 - 07/2017)
- Lawrence Research Award
- Rolanette and Berdon Lawrence Bone Disease Program of Texas (05/2018)
Selected Publications
- Rockel, J.S., Grol, M.W., Bernier, S.M. and Leask, A. "Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes." Matrix Biol.. 2009 Jul;28(6):354-364. Pubmed PMID: 19505573
- Grol, M.W., Panupinthu, N., Korcok, J., Sims, S.M. and Dixon, S.J. "Expression, signaling, and function of P2X7 receptors in bone." Purinergic Signal.. 2009 Jun;5(2):205-221. Pubmed PMID: 19224395
- Milner, J.S., Grol, M.W., Beaucage, K.L., Dixon, S.J. and Holdsworth, D.W. "Finite-element modeling of viscoelastic cells during high-frequency cyclic strain." Journal of Functional Biomaterials. 2012 Mar 22;3(1):209-224.
- Beaucage, K.L., Xiao, A., Pollmann, S.I., Grol, M.W., Beach, R.J., Holdsworth, D.W., Sims, S.M., Darling, M.R. and Dixon, S.J. "Loss of P2X7 nucleotide receptor function leads to abnormal fat distribution in mice." Purinergic Signal.. 2013; Pubmed PMID: 24222214
- Grol, M.W., Pereverzev, A., Sims, S.M. and Dixon, S.J. "P2 receptor networks regulate signaling duration over a wide dynamic range of ATP concentrations." J. Cell Sci.. 2013 Aug 15;126(16):3615-3626. Pubmed PMID: 23750003
- Grol, M.W., Zelner, I. and Dixon, S.J. "P2X7-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells." Am. J. Physiol. Endocrinol. Metab.. 2012 Mar 1;302(5):E561-575. Pubmed PMID: 22185840
- Reyes, J.P., Grol, M.W., Sims, S.M. and Dixon, S.J. "Receptor-independent effects of 2'(3')-O-(4-benzoylbenzoyl)ATP triethylammonium salt on cytosolic pH." Purinergic Signal.. 2013 Dec;9(4):687-693. Pubmed PMID: 23689980
- Dafar, M.O., Grol, M.W., Canham, P.B., Dixon, S.J., and Rizkalla, A.S. "Reinforcement of flowable dental composites with titanium dioxide nanotubes." Dent. Mater.. 2016 Jun;32(6):817-826. Pubmed PMID: 27059772
- Grol, M.W., Brooks, P.J., Pereverzev, A., and Dixon, S.J. "P2X7 nucleotide receptor signaling potentiates the Wnt/β-catenin pathway in cells of the osteoblast lineage." Purinergic Signal.. 2016 Sep;12(3):509-520. Pubmed PMID: 27206526
- Xing, S., Grol, M.W., Grutter, P.H., Dixon, S.J., and Komarova, S.V. "Modeling interactions among individual P2 receptors to explain complex response patterns over a wide range of ATP concentrations." Front. Physiol.. 2016 Jul;7:294. Pubmed PMID: 27468270
- Grol, M.W. and Lee, B.H. "Gene therapy for repair and regeneration of bone and cartilage." Curr. Opin. Pharmacol.. 2018 Jun;40:59-66. Pubmed PMID: 29621661
- Nixon, A.J.*, Grol, M.W.*, Lang, H.M., Ruan, M.Z.C., Stone, A., Begum, L., Chen, Y., Dawson, B., Gannon, F., Plutizki, S., Lee, B.H., and Guse, K. "Disease-modifying osteoarthritis treatment with interleukin-1 receptor antagonist gene therapy in small and large animal models." Arthritis Rheumatol. 2018 Jul 25;Epub ahead of print Pubmed PMID: 30044894
- Stone, A.E.*, Grol, M.W.*, Ruan, M.Z., Dawson, B., Chen, Y., Jiang, M.M., Song, I.W., Jayaram, P., Cela, R., Gannon, F., and Lee, B.H. "Combinatorial Prg4 and Il-1ra gene therapy protects against hyperalgesia and cartilage degeneration in post-traumatic osteoarthritis." Hum. Gene Ther.. 2018 Aug 2;Epub ahead of print Pubmed PMID: 30070147
- Grol, M.W., Stone, A., Ruan, M.Z.C., Guse, K., and Lee, B.H. "Chapter 8 – Prospects of gene therapy for skeletal diseases. In Thakker, R.V., Whyte, M.P., Eisman, J.A., and Igarashi, T. (Eds.)." Genetics of Bone Biology and Skeletal Disease (edn 2). 2018;
- Jayaram, P., Yeh, P., Patel, S.J., Cela, R., Shybut, T.B., Grol, M.W. and Lee, B.H. "Effects of aspirin on growth factor release from freshly isolated leukocyte-rich platelet-rich plasma in healthy men: A prospective fixed-sequence controlled laboratory study." Am J Sports Med. 2019 Mar 19; Pubmed PMID: 30888847
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