Breast Cancer Research Program

The Breast Cancer Research Program has 23 research, four clinical and two adjunct members including multidisciplinary investigators focusing on the biology, genetics, molecular pathology, diagnosis, prevention and treatment of breast cancer. Several faculty are also key members of other cancer center programs, ensuring inter-programmatic in addition to intra-programmatic interactions. Our program members are located in several clinical and basic science departments, including the Lester and Sue Smith Breast Center, a major component of our program.

Clinical research includes investigator-initiated trials, trials directed by the NSABP, TBCRC, the American College of Surgeons, and industry supported trials. Investigators from the Breast Cancer Program have leadership positions in these groups and have lead several important trials. These trials have an impact locally, nationally and globally on the science and clinical management of breast cancer as well as survivorship and quality of life. 

The Breast Cancer Program is home to Baylor’s federally funded Specialized Program in Research Excellence (SPORE) in breast cancer. This highly collaborative grant the oldest and longest funded SPORE, and scientific findings from its projects have been translated into impactful therapeutic and prevention trials.

The overall goal of the Breast Cancer Research Program is to identify the genes and pathways important for breast cancer development and progression and then to translate that information to the bedside for improved diagnosis, treatment and prevention of the disease.  Within that framework, there are research programs focused in the areas of stem cell biology, therapeutic resistance, cross-talk and cell signaling pathways and metastasis with an increasing emphasis on understanding the role of the immune microenvironment.

The Breast Cancer Research Program shares common interests and has significant interactions with several other cancer center programs including Cancer Prevention and Population Sciences, Nuclear Receptor Biology, and Cell and Gene Therapy.