Tumor necrosis factor-a and the failing human heart
Dr. Mann was recognized for elucidating cellular and molecular mechanisms by which tumor necrosis factor (TNF) is expressed in the heart, as well as the consequences of TNF expression in the heart. His laboratory was the first to demonstrate that cardiac myocytes expressed TNF in response to cellular injury and/or exposure to bacterial endotoxins stimulate, thus providing potentially new treatment strategies for attenuating cardiac inflammation and/or cardiac injury.
Dr. Mann’s nomination was based on the following publications:
Yokoyama T, Vaca L, Rossen RD, Durante W, Hazarika P, Mann DL. Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart. J Clin Invest. 1993 Nov;92(5):2303-12.
Kapadia S, Torre-Amione G, Yokoyama T, Mann DL. Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro. Am J Physiol. 1995 Feb;268(2 Pt 2):H517-25.
Torre-Amione G, Kapadia S, Lee J, Bies RD, Lebovitz R, Mann DL. Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation. 1995 Sep 15;92(6):1487-93.
Kapadia S, Lee J, Torre-Amione G, Birdsall HH, Ma TS, Mann DL. Tumor necrosis factor-alpha gene and protein expression in adult feline myocardium after endotoxin administration. J Clin Invest. 1995 Aug;96(2):1042-52.