Nicole Provenza, Ph.D.

Assistant Professor

Email

nprovenz@bcm.edu

Positions

Assistant Professor: Neurosurgery
Baylor College of Medicine
Houston, Texas, United States

McNair Scholar: Baylor College of Medicine

Education

BS from Brown University: Providence, Rhode Island, United States; Biomedical Engineering

MS from Brown University: Providence, Rhode Island, United States; Biomedical Engineering

PhD from Brown University: Providence, Rhode Island, United States; Biomedical Engineering

Postdoctoral Fellowship at Baylor College of Medicine: Houston, Texas, United States

Websites

Provenza Lab

The Provenza laboratory uses an engineering approach to investigate ethologically relevant brain-behavior relationships underlying psychiatric symptoms to develop personalized neuromodulation strategies that will improve outcomes for psychiatric disorders.

Videos

Show Us Your BRAINs Photo and Video Contest: First Prize Video

DBS Lead Placement for OCD: 360 degree view of deep brain stimulation (DBS) lead placement in one participant that underwent DBS surgery for obsessive compulsive disorder (OCD). By: Nicole Provenza, Raissa Mathura, Noam Peled, Evan Dastin-van Rijn, Kelly Bijanki, Sameer Sheth, David Borton, Wayne Goodman, Brown University, Baylor College of Medicine.

Selected Publications

Dang HQ, Provenza NR, Banks GP, Giridharan N, Avendano-Ortega M, McKay SA, Devara E, Shofty B, Storch EA, Sheth SA, Goodman WK. " Attenuating side effects of deep brain stimulation in the bed nucleus of the stria terminalis for obsessive compulsive disorder using current-steering strategies " Brain Stimul. 2023 Mar 20; 16 (2) : 650-652.
Pubmed PMID: 36958600.
Xiao J, Adkinson JA, Myers J, Allawala AB, Mathura RK, Pirtle V, Najera R, Provenza NR, Bartoli E, Watrous AJ, Oswalt D, Gadot R, Anand A, Shofty B, Mathew SJ, Goodman WK, Pouratian N, Pitkow X, Bijanki KR, Hayden B, Sheth SA. " Beta activity in human anterior cingulate cortex mediates reward biases " Nat Commun. 2024 Jul 15; 15 (1) : 5528.
Pubmed PMID: 39009561.
Xiao J, Provenza NR, Asfouri J, Myers J, Mathura RK, Metzger B, Adkinson JA, Allawala AB, Pirtle V, Oswalt D, Shofty B, Robinson ME, Mathew SJ, Goodman WK, Pouratian N, Schrater PR, Patel AB, Tolias AS, Bijanki KR, Pitkow X, Sheth SA. " Decoding Depression Severity From Intracranial Neural Activity " Biol Psychiatry. 2023 Sep 15; 94 (6) : 445-453.
Pubmed PMID: 36736418.
Provenza NR, Paulk AC, Peled N, Restrepo MI, Cash SS, Dougherty DD, Eskandar EN, Borton DA, Widge AS. " Decoding task engagement from distributed network electrophysiology in humans " J Neural Eng. 2019 Aug 16; 16 (5) : 056015.
Pubmed PMID: 31419211.
Provenza NR, Sheth SA. " Disrupted neural rhythms predict response in deep brain stimulation for OCD. " Nat Med. 2024 Jul 19;
Pubmed PMID: 39030267.
Provenza NR, Reddy S, Allam AK, Rajesh SV, Diab N, Reyes G, Caston RM, Katlowitz KA, Gandhi AD, Bechtold RA, Dang HQ, Najera RA, Giridharan N, Kabotyanski KE, Momin F, Hasen M, Banks GP, Mickey BJ, Kious BM, Shofty B, Hayden BY, Herron JA, ..., Sheth SA. " Disruption of neural periodicity predicts clinical response after deep brain stimulation for obsessive-compulsive disorder " Nat Med. 2024 Jul 12;
Pubmed PMID: 38997607.
Najera RA, Provenza N, Dang H, Katlowitz KA, Hertz A, Reddy S, Shofty B, Bellows ST, Storch EA, Goodman WK, Sheth SA. " Dual-Target Deep Brain Stimulation for Obsessive-Compulsive Disorder and Tourette Syndrome " Biol Psychiatry. 2023 Jun 1; 93 (11) : e53-e55.
Pubmed PMID: 36863881.
Provenza NR, Gelin LFF, Mahaphanit W, McGrath MC, Dastin-van Rijn EM, Fan Y, Dhar R, Frank MJ, Restrepo MI, Goodman WK, Borton DA. " Honeycomb: a template for reproducible psychophysiological tasks for clinic, laboratory, and home use " Braz J Psychiatry. 2022 ; 44 (2) : 147-155.
Pubmed PMID: 34320125.
Provenza NR, Sheth SA, Dastin-van Rijn EM, Mathura RK, Ding Y, Vogt GS, Avendano-Ortega M, Ramakrishnan N, Peled N, Gelin LFF, Xing D, Jeni LA, Ertugrul IO, Barrios-Anderson A, Matteson E, Wiese AD, Xu J, Viswanathan A, Harrison MT, ..., Borton DA. " Long-term ecological assessment of intracranial electrophysiology synchronized to behavioral markers in obsessive-compulsive disorder " Nat Med. 2021 Dec 9; 27 (12) : 2154-2164.
Pubmed PMID: 34887577.
Provenza NR, Matteson ER, Allawala AB, Barrios-Anderson A, Sheth SA, Viswanathan A, McIngvale E, Storch EA, Frank MJ, McLaughlin NCR, Cohn JF, Goodman WK, Borton DA. " The Case for Adaptive Neuromodulation to Treat Severe Intractable Mental Disorders " Front Neurosci. 2019 Feb 26; 13 : 152.
Pubmed PMID: 30890909.
Dastin-van Rijn EM, Provenza NR, Calvert JS, Gilron R, Allawala AB, Darie R, Syed S, Matteson E, Vogt GS, Avendano-Ortega M, Vasquez AC, Ramakrishnan N, Oswalt DN, Bijanki KR, Wilt R, Starr PA, Sheth SA, Goodman WK, Harrison MT, Borton DA. " Uncovering biomarkers during therapeutic neuromodulation with PARRM: Period-based Artifact Reconstruction and Removal Method " Cell Rep Methods. 2021 Jun 21; 1 (2) : 100010.
Pubmed PMID: 34532716.

Intellectual Property

Systems, methods, and media for detecting and facilitating an effortful mental task by providing real-time deep brain stimulation: Product Patent #US11612748B2 (Approved); In accordance with some embodiments of the disclosed subject matter, mechanisms (which can, for example, include systems, methods, and media) for detecting an effortful mental state providing real-time deep brain stimulation to enhance performance of effortful mental tasks are provided.; Co Inventors: David Borton, Alik Widge, Darin Dougherty, Emad Eskandar

Period-based artifact reconstruction and removal for deep brain stimulation: Product Patent #US20220338786A1 (Approved); Methods and systems for improved removal of deep brain stimulation artifacts from electrical measurements of brain activity.; Co Inventors: David A. Borton, Evan M. Dastin-van Rijn, Matthew T. Harrison, Paula Chen, Taewoo Kim, Jerome Darbon