Hematology / Oncology, Center for Cell and Gene Therapy
Hematopoietic stem cell differentiation and proliferation
Margaret A. Goodell, Ph.D., received the award for her research on hematopoietic stem cell differentiation and proliferation. Dr. Goodell’s current research attempts to uncover the fundamental mechanisms that regulate stem cells in adults, with the ultimate goal of facilitating their use for cell and gene therapies. She is also attempting to harness adult stem cells for tissue and organ repair, using novel approaches involving cell fusion.
Dr. Goodell’s nomination was based on the following publications:
McKinney-Freeman SL, Jackson KA, Camargo FD, Ferrari G, Mavilio F, Goodell MA. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1341-6.
Camargo FD, Green R, Capetanaki Y, Jackson KA, Goodell MA. Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med. 2003 Dec;9(12):1520-7. Epub 2003 Nov 16.
Venezia TA, Merchant AA, Ramos CA, Whitehouse NL, Young AS, Shaw CA, Goodell MA.Molecular signatures of proliferation and quiescence in hematopoietic stem cells. PLoS Biol. 2004 Oct;2(10):e301.
Dr. Goodell has demonstrated that hematopoietic stem cells (blood system cells) are an integral part of the immune system's response to infection. In an article in Nature, she showed that these stem cells are stimulated by interferon gamma to increase their own reproduction so that they can produce immune system cells that are needed to fight the TB organism Mycobacterium tuberculosis. In a second article in Cell Stem Cell, she and her colleagues showed that not all hematopoietic stem cells are equal and that there are subtypes of these cells that give rise to different kinds of blood cells. She identified the subtype myeloid that gives rise to red blood cells, macrophages (that engulf foreign invaders in the blood stream) and lymphoid that gives rise to the body's immune system. This finding has implications for treatment, indicating that those who would use stem cells in treatment might be more effective if they seek these different subtypes rather than looking for a "pure" stem cells.
Dr. Goodell's nomination was based on the following publications:
Baldrige, M.T., King, K.Y., Boles, N.C., Weksberg, D.C., & Goodell, M.A. (2010) "Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection." Nature, 465(7299), 793-797.
Challen, G.A., Boles, N.C., Chambers, S.M., & Goodell, M.A. (2010) "Distinct hematopoietic stem cell subtypes are differentially regulated by TFG-beta1." Cell Stem Cell, 6, 265-278.