We encourage collaboration between labs to foster the commitment of several groups toward a solution. Collaboration leads to success and to personal growth.
Members A-G
Barth, Patrick - Uncovering and designing membrane protein structure and function
Beeton, Christine - Potassium channel modulators for the treatment of autoimmune diseases
Bellen, Hugo - Analysis of metabolite-mediated synaptic transmission
Cao, Wei - Study of neuroinflammation related to degenerative diseases, esp. Alzheimer’s disease
Catic, Andre - Studying regulators of transcript and transcription factor turnover in stem and cancer cells
Chan, Keith - Identification of drug targets for urothelial cancer stem cells
Chan, Pui-Kwong - Screening anti-tumor effects of Saponin from Chinese medicines
Chang, Eric - Targeting palmitoyl transferase to selectively block Ras localization to the plasma membrane
Chen, Rui - Novel disease gene identification and targeted therapy of inherited human retinal diseases
Conneely, Orla - Discovery of small molecule modulators of orphan nuclear receptors
Cooper, Thomas - Small molecules that neutralize the toxic effects of expanded repeat RNA expressed from mutant myotonic dystrophy alleles
Cruz, Miguel - A2 protein: Novel treatments for systemic inflammation
Decker, William K. - Pharmacologic agonism of the Th-1 immune response
Deng, Lisheng - Development of epigenetic small-molecular modulators against tumor and viruses
Elsea, Sarah - Probing small molecule libraries for RAI1 induced gene
expression
Estes, Mary - Development of inhibitors of enteric viruses
Ferreon, Allan - Protein Misfolding and Aggregation at Single-Molecule Resolution
Ferreon, Josephine - Allostery in Intrinsically Disordered Hub Proteins
Foulds, Charles - Identification of small molecule inhibitors of human NCOA6 activity
Fu, Loning - Synthetic agonists in controlling circadian homeostasis of metabolism and cell proliferation in vivo
Fuqua, Suzanne - Therapeutic targeting of the Rho signaling pathway in hormone-resistant breast cancer
Garcia, Jose Manuel - Growth hormone secretagogues in the treatment of cancer cachexia
Garcia, Thomas - Small molecules for male contraception
Members H-L
Han, Sang Jun - The ERβ/SRC-1 isoform complex drives endometriosis progression
Hartgerink, Jeffrey - Binding of Integrin to different registers of the heterotrimeric mimics of type I collagen.
Hawkins, Shannon - Discovery of drugs that affect endometriotic cell function
Horrigan, Frank - Tissue-specific modulators of BK potassium channels
Hurwitz, Richard - Small molecule control of viral gene therapy and infection
Hyser, Joseph - Pathophysiology of intestinal fluid secretion during diarrhea
Jankowsky, Joanna - Proline mutants for amyloid inhibition
Kheradmand, Farrah - Small molecule inhibitor of SPP1 in cigarette smoke-induced emphysema
Kim, Choel - Targeting cGMP-dependent protein kinase for developing hypertension drugs
Kirienko, Natasha - Small molecule therapies to perturb host-pathogen interactions and promote cellular health
Kosten, Thomas - Novel noradrenergic blockers and copper chelators for cocaine and methamphetamine dependence
Kurie, Jonathan - Role of FKBP10 as a regulator of Lysyl hydroxylase 2 biochemical activity
Lee, Sukyeong - Developing chemical probes to interrogate Hsp90 molecular chaperone function for structure-based drug design
Lerner, Seth - Small molecule treatments for transitional cell carcinoma, non-muscle invasive tumors and urothelial carcinomas of the bladder
Levitt, Jonathan - Small molecule treatments for transitional cell carcinoma, non-muscle invasive tumors and urothelial carcinomas of the bladder
Lewis, Michael - Overcoming treatment resistance in breast cancer and small molecule inhibitors of Stat
Li, Feng - Application of drug metabolism and pharmacokinetics in drug development
Lichtarge, Olivier - Computational tools for gene function predictions and molecular network analyses to identify potential drug screening targets and assays.
Lin, Weei-Chin - Averting the oncogenic functions of mutant p53
Lonard, David - Developing novel coactivator small molecule inhibitors as drugs to treat cancers and metabolic conditions and as contraceptive agents
Lydon, John - Small molecule therapeutics and biomarkers of endometrial disorders
Members M-P
MacKenzie, Kevin - Ligand binding and structure-activity relationship by NMR
Maletic-Savatic, Mirjana - Ligand binding of TLX
Man, Tsz-Kwong "Chris"- Application of computational and OMICS approaches to improve both the diagnosis and prognosis of pediatric cancer patients
Mancini, Michael - High throughput microscopy-based screening of nuclear receptor functions
Mansouri, David - Small-molecule antimicrobics including those with novel mechanism of action
Marcelli, Marco - Search for small molecules inhibiting the activation of the outlaw androgen receptor (AR) variant AR-V7 in castration-resistant prostate cancer
Matzuk, Martin - Small molecules for TGFbeta signaling, cancer, and male contraception
Mims, Martha - Tail-treatment of B-CLL with autologous IL2 and CD40 ligand-expressing tumor cells + lenalidomide
Mitsiades, Nicholas - Developing novel therapeutics for endocrine cancers
Mohan, Chandra - Using zebrafish to identify modifiers of chronic disease
Moore, David - Novel ligands for nuclear receptors CAR and LRH-1
Neilson, Joel R. - Post-transcriptional gene regulation in mammalian development and disease by microRNAs and RNA-binding proteins
Noebels, Jeffrey - Small molecule inhibitors of a brain-specific membrane transporter
Nuchtern, Jed - Target discovery for chemotherapy-resistant pediatric cancer
O'Malley, Bert - Development of small molecule inhibitors for a novel class of proteins: the nuclear receptor coactivators
Osborne, Kent - Inhibitors of AP1 which contribute to endocrine therapy resistance in breast cancer models
Palzkill, Timothy - Development of small molecule inhibitors of antibiotic resistance enzymes
Pangas, Stephanie - Small molecular inhibitors of primary peritoneal and ovarian cancers
Pati, Debananda - Small molecular inhibitors of separase
Pereira, Frederick - Screens for small molecule regulators of circadian rhythms, and for antioxidants against ROS
Peters, Christopher - In vitro small molecule screening for the identification of autophagy modulators
Pfaffinger, Paul - Redesigning potassium channels for improved drug discovery
Phillips, Kevin - Small molecule modulation of the mammalian deiodinases
Phung, Thuy - Investigation of Akt isoform-specific inhibitors
Pollet, Jeroen - Screening protein-excipient interactions to optimize the stability of recombinant vaccine candidates against neglected tropical diseases
Prasad, B.V. Venkatar - Small molecule antivirals for gastroenteric viral pathogens
Members R-Z
Redell, Michele - Novel Stat3 inhibitors for improving outcomes in acute myeloid leukemia; Novel histone methyltransferase inhibitors for improving outcomes in MLL-rearranged acute leukemias
Richards, Joanne - Small molecules that regulate nuclear receptors in ovarian follicle development and epithelial ovarian cancer
Rosen, Jeffrey - HTS assays to identify small molecules that target EMT/TIC pathways in chemoresistant cancers
Savidge, Tor - Small molecule targeting of the Clostridium difficile toxins
Schiff, Rachel - Inhibitors of AP1 which contribute to endocrine therapy resistance in breast cancer models
Sheikh-Hamad, David - Small molecule manipulation of mitochondrial pathways for kidney protection
Sifers, Richard - Small drug-mediated interrogation of mammalian proteostasis networks
Smith, Carolyn - Selective Inhibitors of corepressors for the nuclear receptor superfamily
Song, Yongcheng - Rational design and development of novel small molecule inhibitors of biologically important proteins targeting cancer and infectious diseases
St-Pierre, François - High-throughput screening of genetically encoded sensors of cellular activity
Statsyuk, Alexander - Pharmacological inhibitors of NEDD4 ubiquitin ligase as anticancer therapeutics
Sun, Yuxiang - Ghrelin receptor antagonists in brown fat thermogenesis, adiposity and insulin resistance; Ghrelin and des-acyl ghrelin in muscle atrophy
Tsai, Francis - Exploiting protein structure and function to develop new anti-cancer drugs
Tsai, Ming-Jer - Screening of small molecular compounds for inhibition of COUP-TFII activity
Tuvim, Michael - Synaptotagmin 2 is a novel target for the treatment of mucus hypersecretion in the airway
Tweardy, David - Virtual ligand screening, high throughput fluorescent microscopy screening, and SAR-assisted medicinal chemistry to target STAT proteins
Venken, Koen - Multicolor poly-luciferase assays for quick affordable multiplex analysis of cellular signaling pathways in health and disease
Wang, Jin - Nanotechnology for drug, gene and RNAi delivery
Wang, Meng - Lysosomal signaling molecules in regulation of lipid metabolism and longevity
Wehrens, Xander - Drugs that modify ryanodine receptors for the treatment of heart disease
Weigel, Nancy - Screens for small molecules that interrupt the interface between androgen receptor and p160 coactivators
Wensel, Theodore - Novel therapeutics for retinal neurodegeneration and protein misfolding diseases
Westbrook, Thomas - Multidisciplinary program in genetics and drug discovery to exploit new breast cancer vulnerabilities
Xu, Jianming - Modulators of transcriptional coregulators for inhibition of cancer cell growth
Yang, Feng - MAPK4 as a novel therapeutic target for human cancers
Yang, Jianchang - Role of Sall4 on leukemic hematopoietic and other cancer stem cell regulation
Yang, Jianhua - Targeting oncogenic kinases in neuroblastoma
Yao, Qizhi Cathy - HIV mucosal vaccine development; Pancreatic cancer pathogenesis and immunotherapy
Yen, Laising - Developing riboswitch-based gene regulation systems that can be turned on or off by FDA-approved small molecules
Yi, Joanna - Identifying and translating novel, targeted small molecules to pediatric malignancies
Yi, Ping - The role of TRAF4 in metastatic prostate cancer development
Young, Damian - Fragment-based drug discovery (FBDD) and macrocyclic scaffolds for drug discovery high-throughput screening (HTS)
Yu, Zhifeng - Small molecules for male contraception and ovarian cancer
Yustein, Jason - Discovery of small molecule modulators of orphan nuclear receptors
Zechiedrich, Lynn - Combating multidrug-resistant bacteria; gene therapy approaches for human diseases
Zheng, Hui - Small molecule modulation of cellular clearance as Alzheimer disease therapy
Zhou, Ming - Modulation of membrane transport proteins by small-molecule compounds
Zoghbi, Huda - Identification of protein-protein interactions and screening drug targets to understand sca1 pathogenesis and develop therapies