Andre Catic, M.D., Ph.D.

Associate Professor & CPRIT Scholar in Cancer Research

(713) 798-1567

Email

andre.catic@bcm.edu

Positions

Associate Professor & CPRIT Scholar in Cancer Research: Dept. of Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Instructor in Medicine: 2007-2014
Center for Regenerative Medicine
Massachusetts General Hospital
Boston, Massachusetts, United States

Research Fellow: 2007-2014
Harvard Stem Cell Institute
Boston, Massachusetts, United States

Post-doctoral Associate: 2006
Whitehead Institute/MIT
Cambridge, Massachusetts, United States

Medical Resident: 2000-2001
Charité Hospital
Berlin, Germany

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Education

MD from University of Ulm: 10/1999 - Ulm, Germany

PhD from Harvard University: 06/2006 - Cambridge, MA, United States

Professional Interests

We study protein quality control mechanisms and their involvement in gene regulation, metabolism, and aging.

Professional Statement

Transcription factors are key determinants of cellular metabolism and developmental potential. Their short lifespan allows cells to react quickly to changes in environment and fate. However, it remains largely unexplored how the removal of these regulators affects gene expression and facilitates cellular adaption.
Dr. Catic’s research aims to define the degradation patterns of transcription factors in the context of metabolism, aging, stem cell and cancer biology. The goal of these studies is to change the turnover of select transcription factors and thereby alter distinct genetic programs.

Websites

VIICTR Publications List

Laboratory website

Selected Publications

The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes " Sci Rep.. 2020 ;
Pubmed PMID: 32811853.

Funding

Transcript decay regulates hematopoietic aging #R01DK115454: Grant funding from NIDDK