Josephine Chu Ferreon, Ph.D.

Member

(713) 798-1756

Email

josephine.ferreon@bcm.edu

Positions

Member: Dan L Duncan Comprehensive Cancer Center
Baylor College of Medicine
Houston, Texas, United States

Associate Professor: Biochemistry and Molecular Pharmacology
Baylor College of Medicine
Houston, Texas, USA

Addresses

BCM-Alkek Graduate School (Office): Room: BCMN-N520.03
Houston, TX, 77030
United States

Education

Post-Doctoral Fellowship at The Scripps Research Institute: La Jolla, California, USA; NMR Spectroscopy

PhD from University of Texas Medical Branch: Galveston, Texas, USA; Structural Biology and Biophysical Chemistry

BS from University of the Philippines-Diliman: Quezon City, Philippines; Molecular Biology & Biotechnology

Honors & Awards

Leukemia and Lymphoma Society Special Fellow

James W. McLaughlin Postdoctoral Fellow

Sealy Center for Structural Biology Pre-Doctoral Fellow

Professional Interests

NMR Spectroscopy
Stem Cell Biology
Intrinsically Disordered Proteins
Protein Structure and Function
Post-Translational Modifications

Websites

VIICTR Publications List

Selected Publications

Ferreon ACM*, Ferreon JC*, Wright PE, and Deniz, AA [*co-first authors]. " Modulation of Allostery by Protein Intrinsic Disorder. " Nature. 2013 ; 498 (7454) : 390-4.
Pubmed PMID: 23783631.
Arai M, Ferreon JC, and Wright PE. " Quantitative analysis of multisite protein ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. " J Am Chem Soc. 2012 ; 134 (8) : 3792-803.
Pubmed PMID: 22280219.
Lee CW*, Ferreon JC*, Ferreon ACM, Arai M, and Wright PE [*co-first authors]. " Graded enhancement of p53 binding to CBP/p300 by multisite phosphorylation. " Proc Natl Acad Sci USA. 2010 ; 107 (45) : 19290-5.
Pubmed PMID: 20962272.
Ferreon JC, Martinez-Yamout MA, Dyson HJ, and Wright PE. " Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. " Proc Natl Acad Sci USA. 2009 ; 106 (32) : 13260-5.
Pubmed PMID: 19651603.
Ferreon AC, Moran CR, Ferreon JC, and Deniz AA. " Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson’s disease. " Angew Chem Int Ed Engl. 2010 ; 49 (20) : 3469-72.
Pubmed PMID: 20544898.
Manson A, Whitten ST, Ferreon JC, Fox RO, and Hilser VJ. " Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity. " J Am Chem Soc. 2009 ; 131 (19) : 6785-93.
Pubmed PMID: 19397330.
Ferreon JC, Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, and Wright PE. " Cooperative regulation of p53 by modulation of ternary complex formation with CBP and HDM2. " Proc Natl Acad Sci USA. 2009 ; 106 (16) : 6591-6.
Pubmed PMID: 19357310.
Whitten ST, Ferreon JC, Hamburger JB, and Hilser VJ. " Calorimetric Determination of the Thermodynamics of Polyproline II (PII) Helix Formation. " In the Unfolded States of Protein In Unfolded. 2008 ;
Ferreon ACM, Ferreon JC, Bolen DW, and Rösgen J. " Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes. " Biophys J. 2007 ; 92 (1) : 245-56.
Pubmed PMID: 17028144.
Ferreon JC, Ferreon ACM, Li K, and Lemon SM. " Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. " J Biol Chem. 2005 ; 280 (21) : 20483-92.
Pubmed PMID: 15767257.
Li K, Foy E, Ferreon JC, Nakamura M, Ferreon ACM, Ikeda M, Ray SC, Gale Jr. M, and Lemon SM. " Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. " Proc Natl Acad Sci USA. 2005 ; 102 (8) : 2992-7.
Pubmed PMID: 15710891.
Ferreon JC, Hamburger JB, Whitten ST, and Hilser VJ. " An experimental strategy to evaluate the thermodynamic stability of highly dynamic binding sites in proteins using hydrogen exchange. " J Am Chem Soc. 2004 ; 126 (40) : 12774-5.
Pubmed PMID: 15469262.
Hamburger JB, Ferreon JC, Whitten ST, and Hilser VJ. " Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins. " Biochemistry. 2004 ; 43 (30) : 9790-9.
Pubmed PMID: 15274633.
Ferreon JC and Hilser VJ. " Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation. " Biochemistry. 2004 ; 43 (24) : 7787-97.
Pubmed PMID: 15196021.
Ferguson MR, Fan X, Mukherjee M, Luo J, Khan R, Ferreon JC, Hilser VJ, Shope RE, and Fox RO. " Directed discovery of bivalent peptide ligands to an SH3 domain. " Protein Sci. 2004 ; 13 (3) : 626-32.
Pubmed PMID: 14978303.
Ferreon JC, Volk DE, Luxon BA, Gorenstein DG, and Hilser VJ. " Solution structure, dynamics and thermodynamics of the native state ensemble of the SEM-5 C-terminal SH3 domain. " Biochemistry. 2003 ; 42 (19) : 5582-91.
Pubmed PMID: 12741814.
Ferreon JC and Hilser VJ. " Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of SEM-5 indicate cooperative conformational coupling. " Protein Sci. 2003 ; 12 (5) : 982-996.
Pubmed PMID: 12717021.
Ferreon JC and Hilser VJ. " The effect of the polyproline II (PPII) conformation on the denatured state entropy. " Protein Sci. 2003 ; 12 (3) : 447-457.
Pubmed PMID: 12592015.
Tabbada KA, Magno MM, Delfin FC, Calacal GC, Tan M, C-Ferreon J, Halos SC, and De Ungria MCA. " Allele Frequencies of Eight Short Tandem Repeat Loci in Three Visayas Regional Populations of the Philippines. " J Forensic Sci. 2002 ; 47 (6) : 1397-8.
Pubmed PMID: 12455671.
Soman KV, Midoro-Horiuti T, Ferreon JC, Goldblum RM, Brooks EG, Kurosky A, Braun W, and Schein C. " Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3. " Biophys J. 2000 ; 79 (3) : 1601-9.
Pubmed PMID: 10969020.
Halos SC, Chu JY, Ferreon ACM, and Magno MM. " Philippine population database at nine microsatellite loci for forensic and paternity applications. " Forensic Sci Int. 1999 ; 101 (1) : 27-32.
Pubmed PMID: 10376334.
Halos SC, Fortuno ES 3rd, Ferreon AC, Chu JY, Miranda J, Harada S, and Benecke M. " Allele frequency distributions of the polymorphic STR loci HUMVWA, HUMFES, HUMF13A01 and the VNTR D1S80 in a Filipino population from Metro Manila. " Int J Legal Med. 1998 ; 111 (4) : 224-6.
Pubmed PMID: 9646171.

Memberships

Biophysical Society

Protein Society

Languages

Tagalog