Feng Li, Ph.D.

Professor

(713) 798-3623

Email

feng.li@bcm.edu

Positions

Professor: Center for Drug Discovery; Department of Pathology & Immunology
Baylor College of Medicine
Houston, TX, US

Professor: Department of Biochemistry and Molecular Pharmacology
Baylor College of Medicine

Member: Chemical Physical & Structural Biology Graduate Program
Baylor College of Medicine
Houston, Texas, United States

Co-Director: The Advanced Technology Cores
NMR and Drug Metabolism Core
Baylor College of Medicine
Houston, TX, US

Professional Interests

LC-MS-based metabolomics
Drug metabolism and pharmacokinetics
Drug-induced liver injury
Blood testis barrrier
Imaging Mass Spectrometry

Websites

VIICTR Publications List

Center for Drug Discovery

NMR and Drug Metabolism Advanced Technology Core

Selected Publications

Feng Li, Jie Lu, Jie Cheng, Laiyou Wang, Tsutomu Matsubara, Ivan Csanaky, Curtis D. Klaassen, Frank J. Gonzalez, Xiaochao Ma. " Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy " Nat. Med.. 2013 ; 19 : 418-420.
Pubmed PMID: 23475203.
Xuan Qin , Yong Wang, Qiuji Ye, John M Hakenjos , Jin Wang , Mingxing Teng , Lei Guo, Zhi Tan , Damian W Young, Kevin R MacKenzie, Feng Li*. " CYP3A Mediates an Unusual C(sp)−C(sp) Bond Cleavage via Ipso‐Addition of Oxygen in Drug Metabolism " Angew Chem Int Ed Engl .. 2024 ; 63 (23) : e202405197.
Pubmed PMID: 38574245.
Saleh M Khalil , Xuan Qin, John M Hakenjos, Jian Wang, Zhaoyong Hu, Xinli Liu, Jin Wang, Mirjana Maletic-Savatic, Kevin R MacKenzie, Martin M Matzuk, Feng Li*. " MALDI Imaging Mass Spectrometry Visualizes the Distribution of Antidepressant Duloxetine and Its Major Metabolites in Mouse Brain, Liver, Kidney, and Spleen Tissues " Drug Metab Dispos.. 2024 ; 52 (7) : 673-680.
Pubmed PMID: 38658163.
Shenzhi Zhou, Xuan Qin, Kevin Tran, Jian Wang, Xingyu Ji, Kevin R. MacKenzie, Srinivas Chamakuri, Jin Wang, Feng Li*. " Metabolism, Pharmacokinetics, and Tissue Distribution of a Selective FK506-Binding Protein 12 F36V Mutant Degrader in Mice. " ACS Pharmacol Transl Sci.. 2025 ; 8 : 4410-4422.
Xuan Qin , Cen Xie , John M Hakenjos, Kevin R MacKenzie , Shelton R Boyd, Mercedes Barzi, Karl-Dimiter Bissig , Damian W Young , Feng Li*. " The roles of Cyp1a2 and Cyp2d in pharmacokinetic profiles of serotonin and norepinephrine reuptake inhibitor duloxetine and its metabolites in mice " Eur J Pharm Sci.. 2023 ; 181 : 106358.
Pubmed PMID: 36513193.

Funding

Mechanisms of Liver Toxicity of Anti-Depressant Duloxetine #R01DK121970: Grant funding from NIH/NIDDK

Elucidating Chemical Features that Block or Facilitate Passage across the BloodTestis and/or Blood-Epidydimal Barriers in Mice #R33HD099995: Grant funding from NIH/NICHD