Zheng Zhou Lab

Zhou Lab Publicatations


Haley R, Zhou Z. The small GTPase RAB-35 facilitates the initiation of phagosome maturation and acts as a robustness factor for apoptotic cell clearance. Small GTPases. 2021 May;12(3):188-201. doi: 10.1080/21541248.2019.1680066. Epub 2019 Oct 24. PubMed PMID: 31607221; PubMed Central PMCID: PMC7939568.

Furuta Y, Pena-Ramos O, Li Z, Chiao L, Zhou Z. Calcium ions trigger the exposure of phosphatidylserine on the surface of necrotic cells. PLoS Genet. 2021 Feb;17(2):e1009066. doi: 10.1371/journal.pgen.1009066. eCollection 2021 Feb. PubMed PMID: 33571185; PubMed Central PMCID: PMC7904182.

Farkas Z, Petric M, Liu X, Herit F, Rajnavölgyi É, Szondy Z, Budai Z, Orbán TI, Sándor S, Mehta A, Bajtay Z, Kovács T, Jung SY, Afaq Shakir M, Qin J, Zhou Z, Niedergang F, Boissan M, Takács-Vellai K. The nucleoside diphosphate kinase NDK-1/NME1 promotes phagocytosis in concert with DYN-1/Dynamin. FASEB J. 2019 Oct;33(10):11606-11614. doi: 10.1096/fj.201900220R. Epub 2019 Jul 17. PubMed PMID: 31242766; PubMed Central PMCID: PMC6819981.

Haley R, Wang Y, Zhou Z. The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells. PLoS Genet. 2018 Aug;14(8):e1007558. doi: 10.1371/journal.pgen.1007558. eCollection 2018 Aug. PubMed PMID: 30138370; PubMed Central PMCID: PMC6107108.

Li W, Yi J, Agbu P, Zhou Z, Kelley RL, Kallgren S, Jia S, He X. Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance. PLoS Genet. 2017 Jul;13(7):e1006900. doi: 10.1371/journal.pgen.1006900. eCollection 2017 Jul. PubMed PMID: 28749973; PubMed Central PMCID: PMC5549764.

Li Z, Zhou Z. How are necrotic cells recognized by their predators?. Worm. 2016; 5(1):1-10. doi: 10.1080/21624054.2015.1120400.

Li Z, Zhou Z. How are necrotic cells recognized by their predators?. Worm. 2016 Jan-Mar;5(1):e1120400. doi: 10.1080/21624054.2015.1120400. eCollection 2016 Jan-Mar. PubMed PMID: 27073733; PubMed Central PMCID: PMC4805362.

Li Z, Venegas V, Nagaoka Y, Morino E, Raghavan P, Audhya A, Nakanishi Y, Zhou Z. Necrotic Cells Actively Attract Phagocytes through the Collaborative Action of Two Distinct PS-Exposure Mechanisms. PLoS Genet. 2015 Jun;11(6):e1005285. doi: 10.1371/journal.pgen.1005285. eCollection 2015 Jun. PubMed PMID: 26061275; PubMed Central PMCID: PMC4464654.

Shen Q, He B, Lu N, Conradt B, Grant BD, Zhou Z. Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. Development. 2013 Aug;140(15):3230-43. doi: 10.1242/dev.093732. PubMed PMID: 23861060; PubMed Central PMCID: PMC3931732.

Huang S, Jia K, Wang Y, Zhou Z, Levine B. Autophagy genes function in apoptotic cell corpse clearance during C. elegans embryonic development. Autophagy. 2013 Feb 1;9(2):138-49. doi: 10.4161/auto.22352. Epub 2012 Oct 29. PubMed PMID: 23108454; PubMed Central PMCID: PMC3552879.

Li Z, Lu N, He X, Zhou Z. Monitoring the clearance of apoptotic and necrotic cells in the nematode Caenorhabditis elegans. Methods Mol Biol. 2013;1004:183-202. doi: 10.1007/978-1-62703-383-1_14. PubMed PMID: 23733578; PubMed Central PMCID: PMC4038443.

Sun L, Liu O, Desai J, Karbassi F, Sylvain MA, Shi A, Zhou Z, Rocheleau CE, Grant BD. CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2. PLoS Genet. 2012;8(7):e1002785. doi: 10.1371/journal.pgen.1002785. Epub 2012 Jul 12. PubMed PMID: 22807685; PubMed Central PMCID: PMC3395619.

Lu N, Shen Q, Mahoney TR, Neukomm LJ, Wang Y, Zhou Z. Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 2012 Jan;10(1):e1001245. doi: 10.1371/journal.pbio.1001245. Epub 2012 Jan 17. PubMed PMID: 22272187; PubMed Central PMCID: PMC3260314.

Lu N, Zhou Z. Membrane trafficking and phagosome maturation during the clearance of apoptotic cells. Int Rev Cell Mol Biol. 2012;293:269-309. doi: 10.1016/B978-0-12-394304-0.00013-0. Review. PubMed PMID: 22251564; PubMed Central PMCID: PMC3551535.

Lu N, Shen Q, Mahoney TR, Liu X, Zhou Z. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Mol Biol Cell. 2011 Feb 1;22(3):354-74. doi: 10.1091/mbc.E10-09-0756. PubMed PMID: 21148288; PubMed Central PMCID: PMC3031466.

He B, Yu X, Margolis M, Liu X, Leng X, Etzion Y, Zheng F, Lu N, Quiocho FA, Danino D, Zhou Z. Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells. Mol Biol Cell. 2010 Feb 15;21(4):610-29. doi: 10.1091/mbc.e09-05-0440. Epub 2009 Dec 16. PubMed PMID: 20016007; PubMed Central PMCID: PMC2820425.

Wu HH, Bellmunt E, Scheib JL, Venegas V, Burkert C, Reichardt LF, Zhou Z, Fariñas I, Carter BD. Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat Neurosci. 2009 Dec;12(12):1534-41. doi: 10.1038/nn.2446. Epub 2009 Nov 15. PubMed PMID: 19915564; PubMed Central PMCID: PMC2834222.

He B, Lu N, Zhou Z. Cellular and nuclear degradation during apoptosis. Curr Opin Cell Biol. 2009 Dec;21(6):900-12. doi: 10.1016/j.ceb.2009.08.008. Epub 2009 Sep 24. Review. PubMed PMID: 19781927; PubMed Central PMCID: PMC2787732.

Lu N, Yu X, He X, Zhou Z. Detecting apoptotic cells and monitoring their clearance in the nematode Caenorhabditis elegans. Methods Mol Biol. 2009;559:357-70. doi: 10.1007/978-1-60327-017-5_25. PubMed PMID: 19609769; PubMed Central PMCID: PMC2901927.

Zhou Z, Yu X. Phagosome maturation during the removal of apoptotic cells: receptors lead the way. Trends Cell Biol. 2008 Oct;18(10):474-85. doi: 10.1016/j.tcb.2008.08.002. Epub 2008 Sep 4. Review. PubMed PMID: 18774293; PubMed Central PMCID: PMC3125982.

Yu X, Lu N, Zhou Z. Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells. PLoS Biol. 2008 Mar 18;6(3):e61. doi: 10.1371/journal.pbio.0060061. PubMed PMID: 18351800; PubMed Central PMCID: PMC2267821.

Mangahas PM, Yu X, Miller KG, Zhou Z. The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. J Cell Biol. 2008 Jan 28;180(2):357-73. doi: 10.1083/jcb.200708130. PubMed PMID: 18227280; PubMed Central PMCID: PMC2213587.

Zhou Z. New phosphatidylserine receptors: clearance of apoptotic cells and more. Dev Cell. 2007 Dec;13(6):759-60. doi: 10.1016/j.devcel.2007.11.009. Review. PubMed PMID: 18061557.

Venegas V, Zhou Z. Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans. Mol Biol Cell. 2007 Aug;18(8):3180-92. doi: 10.1091/mbc.e07-02-0138. Epub 2007 Jun 13. PubMed PMID: 17567952; PubMed Central PMCID: PMC1949360.

Hamon Y, Trompier D, Ma Z, Venegas V, Pophillat M, Mignotte V, Zhou Z, Chimini G. Cooperation between engulfment receptors: the case of ABCA1 and MEGF10. PLoS One. 2006 Dec 27;1:e120. doi: 10.1371/journal.pone.0000120. PubMed PMID: 17205124; PubMed Central PMCID: PMC1762421.

Yu X, Odera S, Chuang CH, Lu N, Zhou Z. C. elegans Dynamin mediates the signaling of phagocytic receptor CED-1 for the engulfment and degradation of apoptotic cells. Dev Cell. 2006 Jun;10(6):743-57. doi: 10.1016/j.devcel.2006.04.007. PubMed PMID: 16740477.

Mangahas PM, Zhou Z. Clearance of apoptotic cells in Caenorhabditis elegans. Semin Cell Dev Biol. 2005 Apr;16(2):295-306. doi: 10.1016/j.semcdb.2004.12.005. Epub 2005 Jan 20. Review. PubMed PMID: 15797839.

Zhou Z, Mangahas PM, Yu X. The genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster. Curr Top Dev Biol. 2004;63:91-143. doi: 10.1016/S0070-2153(04)63004-3. Review. PubMed PMID: 15536015.

Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Dev Cell. 2001 Oct;1(4):477-89. doi: 10.1016/s1534-5807(01)00058-2. PubMed PMID: 11703939.

Zhou Z, Hartwieg E, Horvitz HR. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans. Cell. 2001 Jan 12;104(1):43-56. doi: 10.1016/s0092-8674(01)00190-8. PubMed PMID: 11163239.

Chen F, Hersh BM, Conradt B, Zhou Z, Riemer D, Gruenbaum Y, Horvitz HR. Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death. Science. 2000 Feb 25;287(5457):1485-9. doi: 10.1126/science.287.5457.1485. PubMed PMID: 10688797.

Huang M, Zhou Z, Elledge SJ. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell. 1998 Sep 4;94(5):595-605. doi: 10.1016/s0092-8674(00)81601-3. PubMed PMID: 9741624.

Sanchez Y, Zhou Z, Huang M, Kemp BE, Elledge SJ. Analysis of budding yeast kinases controlled by DNA damage. Methods Enzymol. 1997;283:398-410. doi: 10.1016/s0076-6879(97)83033-9. PubMed PMID: 9251037.

Navas TA, Zhou Z, Elledge SJ. DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell. 1995 Jan 13;80(1):29-39. doi: 10.1016/0092-8674(95)90448-4. PubMed PMID: 7813016.

Allen JB, Zhou Z, Siede W, Friedberg EC, Elledge SJ. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 1994 Oct 15;8(20):2401-15. doi: 10.1101/gad.8.20.2401. PubMed PMID: 7958905.

Elledge SJ, Zhou Z, Allen JB, Navas TA, Jones WJ. DNA damage and cell cycle regulation in S. cerevisiae. . In: The Cell Cycle: Regulators, Targets, and Clinical Applications. Hu VW, editor. New York: Plenum Press; 1994. p.163-166.

Zhou Z, Elledge SJ. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell. 1993 Dec 17;75(6):1119-27. doi: 10.1016/0092-8674(93)90321-g. PubMed PMID: 8261511.

Elledge SJ, Zhou Z, Allen JB, Navas TA. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays. 1993 May;15(5):333-9. doi: 10.1002/bies.950150507. Review. PubMed PMID: 8343143.

Zhou Z, Elledge SJ. Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics. 1992 Aug;131(4):851-66. PubMed PMID: 1516817; PubMed Central PMCID: PMC1205097.

Elledge SJ, Zhou Z, Allen JB. Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci. 1992 Mar;17(3):119-23. doi: 10.1016/0968-0004(92)90249-9. Review. PubMed PMID: 1412696.

Elledge SJ, Zhou Z. Cell cycle and DNA damage regulation of ribonucleotide reductase in Saccharomyces cerevisiae. . In: Induced Effects of Genotoxic Agents in Eukaryotic Cells. Rossman TG, editor. Washington, D. C.: Hemisphere Publishing Corporation; 1992. p.65-80.