Eberlin Lab

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Eberlin Lab Publications

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  1. D. Awad, P.H.A. Cao, T.L. Pulliam, M.L. Spradlin, E. Subramani, T.V. Tellman, C.F. Ribeiro, R. Muzzioli, B.E. Jewell, H. Pakula, J.J. Ackroyd, M.M. Murray, J.J. Han, M. Leng, A. Jain, B. Piyarathna, J. Liu, X. Song, J. Zhang, A.R. Klekers, J.M. Drake, M.M. Ittmann, C. Coarfa, D. Piwnica-Worms, M.C. Farach-Carson, M. Loda, L.S. Eberlin, D.E. Frigo, “Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity”. Cancer Research, 2023, doi: 10.1158/0008-5472.CAN-23-0555. PMID: 38038968
  2. S. Corvigno, S. Badal, M.L Spradlin, M. Keating, I. Pereira, E. Stur, Emine Bayraktar, K.I. Foster, N.W. Bateman, W. Barakat, K.M. Karcy, T.P. Conrads, G.L. Maxwell, P.L. lorenzi, S.K. Lutgendorf, Y. Wen, L. Zhao, P.H. Thaker, M.J. Goodheart, J. Liu, N. Fleming, S. Lee, L.S. Eberlin, A.K. Sood. “In situ profiling reveals metabolic alterations in the tumor microenvironment of ovarian cancer after chemotherapy”. NPJ Precis. Onc. 2023, 7, 115. https://doi.org/10.1038/s41698-023-00454-0J.R. PMID: 37923835
  3. J.R. Chappel, M.E. King, J. Fleming, L.S. Eberlin*, D.M. Reif*, E.S. Baker*, “Aggregated Molecular Phenotype Scores: Enhancing Assessment and Visualization of Mass Spectrometry Imaging Data for Tissue-Based Diagnostics”, Analytical Chemistry, 2023, 95, 34, 12913–12922; doi.org/10.1021/acs.analchem.3c02389 *co-corresponding authors PMID: 37579019
  4. R.J. DeHoog, M.E. King, M.F. Keating, J. Zhang, M. Sans, C.L. Feider, K.Y. Garza, A. Bensussan, A. Krieger, J.Q. Lin, S. Badal, E. Alore, C. Pirko, K. Brahmbhatt, W. Yu, R. Grogan, L.S. Eberlin*, and J. Suliburk*, “Intraoperative Identification of Thyroid and Parathyroid Tissues during Human Cervical Endocrine Surgery using the MasSpec Pen”, JAMA Surgery, 2023, accepted PMID: 37531134
  5. R.J. DeHoog, M. Lin, G. Roman, R. Martin, J. Suliburk, and L.S. Eberlin, “Evaluating the Generalizability of Predictive Classifiers Built from DESI Imaging Lipid Data across Mass Spectrometry Platforms” Journal of the American Society for Mass Spectrometry, 2023, https://pubs.acs.org/doi/full/10.1021/jasms.3c00075 PMID: 37294704
  6. A.C. Krieger, L.A. Macias, J.C. Goodman, J.S. Brodbelt, and L.S. Eberlin, “Mass Spectrometry Imaging Reveals Abnormalities in Cardiolipin Composition and Distribution in Astrocytoma Tumor Tissues”, Cancers, 2023, 15, 2842 PMID: 37345179
  7. M.E. King, M. Lin, M. Spradlin, L.S. Eberlin, “Advances and Emerging Medical Applications of Direct Mass Spectrometry Technologies for Tissue Analysis”, Annual Review of Analytical Chemistry, 2023, 16 PMID: 36944233
  8. M.E. King, R. Yuan, J. Chen. K. Pradhan, I. Sariol, S. Li, A. Chakraborty, O. Ekpenyong, J.H. Yearley, J.C. Wong, L. Zúñiga, D. Tomazela, M. Beaumont, J.H. Han, L.S. Eberlin, “Long-chain polyunsaturated lipids associated with responsiveness to anti-PD-1 therapy are colocalized with immune infiltrates in the tumor microenvironment” Journal of Biological Chemistry, 2023, 299, 3, 102902 PMID: 36642178
  9. D. Glassman, M.S. Kim, M. Spradlin, S. Badal, M. Taki, P. Bhattacharya, P. Dutta, C.V. Kingsley, K.I. Foster, O. Animasahun, J.H. Jeon, A. Achreja, A. Jayaraman, P. Kumar, M. Nenwani, F. Wuchu. E. Bayraktar, Y. Wu, E. Stur, L. Mangala, S. Lee, T.A. Yap, S.N. Westin, L.S. Eberlin, D. Nagrath, A.K. Sood, “Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer”, iScience, 2023, 106020 PMID: 3682428.
  10. S.C. Povilaitis, A. Chakraborty, L.M. Kirkpatrick, R.D. Downey, S.B. Hauger, L.S. Eberlin, “Identifying Clinically Relevant Bacteria Directly from Culture and Clinical Samples with a Handheld Mass Spectrometry Probe”, Clinical Chemistry, 2022, 68, 11, 1459-1470 PMID: 36103272
  11. M. Lin, M.S. Blevins, M. Sans, J.S. Broadbelt, L.S. Eberlin, “Deeper Understanding of Solvent-Based Ambient Ionization Mass Spectrometry: Are Molecular Profiles Primarily Dictated by Extraction Mechanisms?”, Analytical Chemistry, 2022, 94, 42, 14734-14744 PMID: 36228313
  12. A.C. Krieger, S.C. Povilaitis, P. Gowda, L.A. O’Connell, L.S.Eberlin, “Noninvasive Detection of Chemical Defenses in Poison Frogs Using the MasSpec Pen”, American Chemical Society, 2022, 2, 5, 475-484 PMID: 36281295
  13. D. Glassman, M.S. Kim, S. Badal, M. Spradlin, O. Animasahun, J.H. Jeon, A. Achreja, A. Jayaraman, P. Kumar, M. Nenwani, F. Wuchu, E. Bayraktar, Y. Wu. E. Stur, L. Mangala, S. Lee, T.A. Yap, S.N. Westin, L.S. Eberlin, D. Nagrath, A.K. Sood, “What’s next after bevaciumab resistance? Targeting metabolic vulnerabilities in ovarian cancer”, Gynecologic Oncology (022), 2022, 166, 1, S17-S18 PMID: 36824283
  14. M. Lin, L.S. Eberlin, E. Seeley, “Reduced Hemoglobin Signal and Improved Detection of Endogenous Proteins in Blood-Rich Tissues for MALDI Mass Spectrometry Imaging”, Journal of the American Society for Mass Spectrometry, 2022, 33, 296–303 PMID: 35061381
  15. L. Macias, K.Y. Garza, C.L. Feider, L.S. Eberlin, J.S. Brodbelt, “Relative Quantitation of Unsaturated Phosphatidylcholines using 193 nm Ultraviolet Photodissociation Parallel Reaction Monitoring Mass Spectrometry”, Journal of the American Chemical Society, 2021, 143, 14622–14634 PMID: 34486374
  16. J. Zhang, M. Sans, R.J. DeHoog, K.Y. Garza, M.E. King, C.L. Feider, A. Bensussan, M.F. Keating, J.Q. Lin, S. Povilaitis, N. Katta, T.E. Milner, W. Yu, C. Nagi, S. Dhingra, C. Pirko, K.A. Brahmbhatt, G. Van Buren, S. Carter, A. Thompson, R.H. Grogan, J. Suliburk, and L.S. Eberlin, “Clinical Translation and Evaluation of the MasSpec Pen Technology for Surgical Use”, Clinical Chemistry, 2021, 67, 1271–1280 PMID: 34263289
  17. K. Y. Garza, A. A. Silva, J. R. Rosa, M. F. Keating, S. C. Povilaitis, M. Spradlin, P. H. Sanches, A. Varao Moura, J. Marrero Gutierrez, J. Q. Lin, J. Zhang, R. J. DeHoog, A. Bensussan, S. Badal, D. Cardoso de Oliveira, P. H. Dias Garcia, L. Dias de Oliveira Negrini, M. Antonio, T. C. Canevari, M. N. Eberlin, R. Tibshirani, L. S. Eberlin*, and A. M. Porcari*, “Rapid screening of COVID-19 directly from Clinical Nasopharyngeal Swabs using The MasSpec Pen,” Analytical Chemistry, 2021, 93, 12582–12593; *co-corresponding authors PMID: 34432430
  18. M. E. King, J. Zhang, J.Q. Lin, K.Y. Garza, R.J. DeHoog, C.L. Feider, A. Bensussan, M. Sans, A. Krieger, S. Badal, M.F. Keating, S. Woody, S. Dhingra, W. Yu, C. Pirko, K. Brahmbhatt, G.Van Buren, W.E. Fisher, J. Suliburk, and L.S. Eberlin, “Rapid Diagnosis and Tumor Margin Assessment During Pancreatic Cancer Surgery with the MasSpec Pen Technology”, Proceedings of the National Academy of Sciences U.S.A., 2021, 118, e2104411118 PMID: 34260388
  19. C.L. Feider, A. Gatmaitan, T. Hooper, A. Chakraborty, P. Gowda, E. Buchanan, and L.S. Eberlin, “Integrating the MasSpec Pen with Sub-Atmospheric Pressure Chemical Ionization for Rapid Chemical Analysis and Forensic Applications”, Analytical Chemistry, 2021, 93, 21, 7549–7556 PMID: 34008955
  20. A. Vaughn, R.J. DeHoog, L.S. Eberlin, and D. R. Appling, “Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization imaging mass spectrometry”, Analytical and Bioanalytical Chemistry, 2021, 413, 3573–3582 PMID: 33829277
    N. Gatmaitan, J. Q. Lin, J. Zhang, and L. S. Eberlin, “Rapid Analysis and Authentication of Meat Using the MasSpec Pen Technology,” Journal of Agricultural and Food Chemistry, 2021, 69, 11, 3527–3536 PMID: 33719440
  21. V. Bensussan, J. Lin, C. Guo, R. Katz, S. Krishnamurthy, E. Cressman, and L. S. Eberlin, “Distinguishing Non-Small Cell Lung Cancer Subtypes in Fine Needle Aspiration Biopsies by Desorption Electrospray Ionization Mass Spectrometry Imaging,” Clinical Chemistry, 2020, 66, 1424-1433. †featured on cover PMID: 33141910
  22. J. Zhang, M. Sans, K. Y. Garza, and L. S. Eberlin, “Mass Spectrometry Technologies to Advance Care for Cancer Patients in Clinical and Intraoperative Use,” Mass Spectrometry Reviews, 2020 PMID: 33094861
  23. G. Zhang, J. Zhang, R.J. DeHoog, S. Pennathur, C.R. Anderton, M.A. Venkatachalam, T. Alexandrov, L.S. Eberlin, and K. Sharma, “DESI MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules”, Metabolomics, 2020, 16, 11 PMID: 31925564
  24. M. F. Keating, J. Zhang, C. L. Feider, S. Retailleau, R. Reid, A. Antaris, B. Hart, G. Tan, T. E. Milner, K. Miller, and L. S. Eberlin, “Integrating the MasSpec Pen to the da Vinci Surgical System for In Vivo Tissue Analysis during a Robotic Assisted Porcine Surgery,” Analytical Chemistry, 2020, 92, 11535-11542 PMID: 32786489
  25. C.L. Feider, L.A. Macias, J. Brodbelt, and L.S. Eberlin, “Double Bond Characterization of Free Fatty Acids Directly from Biological Tissues by Ultraviolet Photodissociation”, Analytical Chemistry, 2020, 92, 8396-8395 PMID: 32421308
  26. M. Sans, A. Krieger, B.R. Wygant, K.Y. Garza, B.C. Mullins, and L.S. Eberlin, “Spatially Controlled Molecular Analysis of Biological Samples Using Nanodroplet Arrays and Direct Droplet Aspiration,” Journal of the American Society for Mass Spectromtry. 2020, 31, 418-428 PMID: 32031393
  27. J. Zhang, S. Q. Li, J. Q. Lin, W. Yu, and L. S. Eberlin, “Mass Spectrometry Imaging enables Discrimination of Renal Oncocytoma from Renal Cell Cancer Subtypes and Normal Kidney Tissues,” Cancer Research, 2020, 80, 689-698 PMID: 31843980
  28. L.A. Macias, C.L. Feider, L.S. Eberlin, and J.S. Brodbelt, “Hybrid 193 nm Ultraviolet Photodissociation Mass Spectrometry Localizes Cardiolipin Unsaturations,” Analytical Chemistry, 2019, 91, 12509-12516 PMID: 31490676
  29. R. DeHoog, J. Zhang, E. Alore, J.Q. Lin, W. Yu, S. Woody, C. Almendariz, M. Lin, A.F. Engelsman, S.B. Sidhu, R. Tibshirani, J. Suliburk, and L.S. Eberlin, “Preoperative Metabolic Classification of Thyroid Nodules using Mass Spectrometry Imaging of Fine Needle Aspiration Biopsies,” Proceedings of the National Academy of Sciences U.S.A. 2019, 116, 21401-21408 PMID: 31591199
  30. C.L. Feider, S. Woody, S. Ledet, J. Zhang, K. Sebastian, M.T. Breen, and L.S. Eberlin, “Molecular Imaging of Endometriosis Tissues using Desorption Electrospray Ionization Mass Spectrometry,” Scientific Reports. 2019, 9, 15690 PMID: 31666535
  31. C.L. Feider, A. Krieger, R.J. DeHoog, and L.S. Eberlin, “Ambient Ionization Mass Spectrometry: Recent Developments and Applications,” Analytical Chemistry, 2019, 91, 4266-4290 PMID: 30790515
  32. M. Sans, J. Zhang, J.Q. Lin, C.L. Feider, N. Giese, M.T. Breen, K. Sebastian, J. Liu, A.K. Sood, and L.S. Eberlin, “Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer,” Clinical Chemistry 2019, 65, 674-683 PMID: 30770374 *featured on cover *Ranked as top 5 of the most read Clinical Chemistry manuscripts in 2019
  33. C.L. Feider, R.J. DeHoog, M. Sans, J. Zhang, A. Krieger, and L.S. Eberlin, “DESI Spray Stability in the Negative Ion Mode Is Dependent on Relative Humidity,” Journal of the American Society for Mass Spectrometry, 2019, 30, 376-380 PMID: 30569427
    O. Simoska, M. Sans, M.D. Fitzpatrick, C.M. Crittenden, L.S. Eberlin, J.B. Shear, and K.J. Stevenson, “Real-Time Electrochemical Detection of Pseudomonas aeruginosa Phenazine Metabolites Using Transparent Carbon Ultramicroelectrode Arrays,” ACS Sensors, 2019, 4, 170-179 PMID: 30525472
  34. A.M. Porcari, J. Zhang, K.Y. Garza, R.M. Rodrigues-Peres, J. Lin, J.H. Young, R. Tibshirani, C. Nagi, G.R. Paiva, S.A. Carter, L.O. Sarian, M.N. Eberlin, and L.S. Eberlin, “A Multi-Center Study Using Desorption Electrospray Ionization Mass Spectrometry Imaging for Breast Cancer Diagnosis” Analytical Chemistry, 2018, 90, 11324–11332 PMID: 30170496
  35. D.R. Klein, C.L. Feider, K.Y. Garza, J.Q. Lin, L.S. Eberlin, and J.S. Brodbelt, “Desorption Electrospray Ionization Coupled with Ultraviolet Photodissociation for Characterization of Phospholipid Isomers in Tissue Sections,” Analytical Chemistry, 2018, 90, 10100-10104 PMID: 30080398
  36. K.Y. Garza, C. Feider, D.R. Klein, J. Rosenberg, J.S. Brodbelt, and L.S. Eberlin, “Desorption Electrospray Ionization Mass Spectrometry Imaging of Proteins Directly from Biological Tissue Sections,” Analytical Chemistry 2018, 90, 7785-7789 PMID: 29800516
  37. Gharpure, S. Pradeep, M. Sans, R. Rupaimoole, C. Ivan, S.Y. Wu, A.S. Nagaraja, L.S. Mangala, X. Zhang, M. Haemmerle, W. Hu, C. Rodriguez-Aguayo, M. McGuire, G.A. Pena, R. Kondetimmanahalli, R. Nini, P. Koppula, P. Ram, S.L. Tucker, G. Lopez-Berestein, K. Baggerly, L.S. Eberlin, and A.K. Sood, “FABP4 as a molecular determinant of residual disease in ovarian cancer”, Nature Communications, 2018, 9:2923 PMID: 30050129
  38. M. Sans, C.L. Feider, and Livia S. Eberlin, “Advances in Mass Spectrometry Imaging coupled to Ion Mobility Spectrometry for Enhanced Imaging of Biological Tissues”, Current Opinion in Chemical Biology, 2017, 42, 138-146 PMID: 29275246
  39. J. Zhang, J. Rector, J. Lin, J.H. Young, M. Sans, N. Katta, N. Giese, W. Yu, C. Nagi, J. Suliburk, J. Liu, A. Bensussan, R.J. DeHoog, K.Y. Garza, B. Ludolph, A.G.Sorace, A. Syed, A. Zahedivash, T. Milner, and L.S. Eberlin, “Nondestructive Tissue Analysis for Ex Vivo and In Vivo Cancer Diagnosis using a Handheld Mass Spectrometry System”, Science Translational Medicine, 2017, 9, eaan3968 PMID: 28878011 †featured in the cover; Altmetric Score: 1679 *Ranked #1 of articles of similar age in Science Translational Medicine.*Ranked #9 of all articles ever published in Science Translational Medicine.
  40. M. Sans, K. Gharpure, R. Tibshirani, J. Zhang, L. Liang, J. Liu, A.K. Sood, and L. S. Eberlin, “Metabolic Markers and Statistical Prediction of Serous Ovarian Cancer Aggressiveness by Ambient Ionization Mass Spectrometry Imaging”, Cancer Research, 2017, 77, 2903-2913 PMID: 28416487
  41. J. Zhang, C. Feider, C. Nagi, W. Yu, S. A. Carter, J. Suliburk, H. S. Tran Cao, and L. S. Eberlin, “Detection of Metastatic Breast and Thyroid Cancer in Lymph Nodes by Desorption Electrospray Ionization Mass Spectrometry Imaging”, Journal of the American Society of Mass Spectrometry, 2017, 28, 1166-1174 PMID: 28247296
  42. A.M. Gouw, L.S. Eberlin, K. Margulis, D.K. Sullivan, G.G. Toal, L. Tong, R.N. Zare, D.W. Felsher, “Oncogene KRAS activates fatty acid synthase, resulting in specific ERK and lipid signatures associated with lung adenocarcinoma”, Proceedings of the National Academy of Sciences U.S.A., 2017, 114, 4300-4305 PMID: 28400509
  43. C.L. Feider, N. Elizondo, and L.S. Eberlin, “Ambient Ionization and FAIMS Mass Spectrometry for Enhanced Imaging of Multiply Charged Molecular Ions in Biological Tissues”, Analytical Chemistry, 2016, 88, 11533-11541 PMID: 27782388
  44. J. Zhang, W. Yu, S. Ryu, J. Lin, G. Buentello, R. Tibshirani, J. Suliburk, and L.S. Eberlin, “Cardiolipins are biomarkers of mitochondria-rich thyroid oncocytic tumors”, Cancer Research, 2016, 76, 6588-6597 PMID: 27659048
  45. J. Zhang, W. Yu, J. Suliburk, and L.S. Eberlin, “Will ambient ionization mass spectrometry become an integral technology in the operating room of the future?”, Clinical Chemistry, 2016, 62, 1172-1174 PMID: 27430706
  46. D.R. Ifa and L.S. Eberlin, “Ambient Ionization Mass Spectrometry for Cancer Diagnosis and Surgical Margin Evaluation”, Clinical Chemistry, 2016, 62, 111-123 PMID: 26555455
  47. L.S. Eberlin, K. Margulis, I. Planell-Mendez, R.N. Zare, R. Tibshirani, T.A. Longacre, M. Jalali, J.A. Norton, and G.A. Poultsides, “Pancreatic Cancer Surgical Resection Margins: Molecular Assessment by Mass Spectrometry Imaging”, Plos Medicine, 2016, 13, e1002108 PMID: 27575375
  48. M.T. Dulay, L.S. Eberlin, and R.N. Zare, “Protein Analysis by Ambient Ionization Mass Spectrometry Using Trypsin-Immobilized Organosiloxane Polymer Surfaces”, Analytical Chemistry, 2015, 87, 12324-12330 PMID: 26567450
  49. E.H. Shroff, L.S. Eberlin, V.M. Dang, A.M. Guow, M. Gabay, S.J. Adam, D.I. Bellovin, P.T. Tran, W.M. Philbrick, A. Garcia-Ocana, S.C. Casey, Y.L. Li, C.V. Dang, R.N. Zare and D.W. Felsher, “MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism”, Proceedings of the National Academy of Sciences U.S.A., 2015, 112, 6539-6544 PMID: 25964345
  50. K.D. Bemis, A. Harry, L.S. Eberlin, C. Ferreira, S.M. van de Ven, P. Mallick, M. Stolowitz, O. Vitek, “Cardinal: an R package for statistical analysis of mass spectrometry-based imaging experiments”, Bioinformatics, 2015, 31, 2418-2420 PMID: 25777525
  51. E.H. Shroff, L.S. Eberlin, V.M. Dang, A.M. Guow, M. Gabay, S.J. Adam, D.I. Bellovin, P.T. Tran, W.M. Philbrick, A. Garcia-Ocana, S.C. Casey, Y.L. Li, C.V. Dang, R.N. Zare and D.W. Felsher, “ MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism”, Proceedings of the National Academy of Sciences of the U.S.A., 2015, 112, 6539-6544 PMID: 25964345
  52. L.S. Eberlin, M. Gabay, A.C. Fan, R. Tibshirani, D. Felsher, and R.N. Zare, “Alteration of the Lipid Profile in Lymphomas Induced by MYC Overexpression”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 10450-10455 PMID: 24994904
    L.S. Eberlin, J.V. Mulcahy, A. Tzabazis, J. Zhang, M. Logan, H.J. Roberts, G.K. Lee, D.C. Yeomans, J. Du Bois, and R.N. Zare, “Visualizing Dermal Permeation of Sodium Channel Modulators by Mass Spectrometric Imaging”, Journal of the American Chemical Society, 2014, 136, 6401-6405 PMID: 24708172
  53. L.S. Eberlin, R. Tibshirani, J. Zhang, T.A. Longacre, G. Berry, D.B. Bingham, J.A. Norton, R.N. Zare and G.A. Poultsides, “Molecular Assessment of Gastric Cancer Surgical Resection Margins by Mass Spectrometric Imaging”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 2436-2441 PMID: 24550265
  54. S. Santagata*, L.S. Eberlin*, I. Norton, D. Calligaris, D.R. Feldman, J.L. Ide, X. Liu, J.S. Wiley, M.L. Vestal, S.H. Ramkissoon, D.A. Orringer, K.K. Gill, I.F. Dunn, D. Dias-Santagata, K.L. Ligon, F.A. Jolesz, A.J. Golby, R.G. Cooks, and N.Y.R. Agar, “Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery”, Proceedings of the National Academy of Sciences of the U.S.A., 2014, 111, 11121-11126 PMID: 24982150 [*equal contribution]
  55. D. Calligaris, I. Norton, D.R. Feldman, J.L. Ide, I.F. Dunn, L.S. Eberlin, R.G. Cooks, F.A. Jolesz, A.J. Golby, S. Santagata and N.Y.R. Agar, “ Mass spectrometry imaging as a tool for surgical decision-making”, Journal of Mass Spectrometry, 2013, 48, 1178-1187 PMID: 24259206
  56. L.S. Eberlin, I. Norton, D. Orringer, I. F. Dunn, X. Liu, J.L. Ide, A.K. Jarmusch, K.L. Ligon, F.A. Jolesz, A.J. Golby, S. Santagata, N.Y. R. Agar and R.G. Cooks, “Ambient Mass Spectrometry for the Intraoperative Molecular Diagnosis of Human Brain Tumors”, Proceedings of the National Academy of Sciences of the U. S.A., 2013, 110, 1611-1616 PMID: 23300285
  57. Gholami, I. Norton, L.S. Eberlin, N.Y.R. Agar, “A Statistical Modeling Approach for Tumor-Type Identification in Surgical Neuropathology Using Tissue Mass Spectrometry Imaging”, IEEE Journal of Biomedical and Health Informatics, 2013, 17, 734-744 PMID: 24592474
  58. Wu, A.L. Dill, L.S. Eberlin, R.G. Cooks and Demian R. Ifa, “Mass Spectrometry Imaging under Ambient Conditions”, Mass Spectrometry Reviews, 2013, 32, 218-243 PMID: 22996621
  59. A.H.L. Machado, H.M.S. Milagre, L.S. Eberlin, A.A. Sabino, C.R.D. Correia, M.N. Eberlin, “Dba-free palladium intermediates of the Heck-Matsuda reaction”, Organic & Biomolecular Chemistry, 2013, 11, 3277-3281 PMID: 23511838
  60. A.F. Gonzalez-Serrano, V. Pirro, C.R. Ferreira, P. Oliveri, L.S. Eberlin, J. Heinzmann, A. Lucas-Hahn, H. Niemann and R.G. Cooks, “Desorption Electrospray Ionization Reveals Lipid Metabolism of Individual Oocytes and Embryos”, PloS ONE, 2013, 8, e74981 PMID: 24073231
  61. L.S. Eberlin, I. Norton, A.L. Dill, A.J. Golby, K.L. Ligon, S. Santagata, R.G. Cooks and N.Y.R. Agar, "Classifying Human Brain Tumors by Lipid Imaging with Mass Spectrometry", Cancer Research, 2012, 72, 645-654 PMID: 22139378
  62. A.K. Badu-Tawiah, L.S. Eberlin, Z. Ouyang and R.G. Cooks, "Chemical Aspects of the Extractive Methods of Ambient Ionization Mass Spectrometry", Annual Review of Analytical Chemistry, 2013, 64,481-505 PMID: 23331308
  63. C.R. Ferreira, V. Pirro, L.S. Eberlin, J.E. Hallett and R.G. Cooks, "Developmental Phases in Individual Mouse Preimplantation Embryos Characterized by Lipid Signatures in Desorption Electrospray Ionization Mass Spectrometry", Analytical and Bioanalytical Chemistry, 2012, 404, 2915-2926 PMID: 23052870
  64. D.I. Campbell, C.R. Ferreira, L.S. Eberlin, R.G. Cooks, "Improved spatial resolution in the imaging of biological tissue using desorption electrospray ionization", Analytical and Bioanalytical Chemistry, 2012, 404, 389 -398 PMID: 22706326
  65. X. Xiong, W. Xu, L.S. Eberlin, J.M. Wiseman, X.Fang, Y. Jiang, Z. Huang, Y. Zhang, R.G. Cooks, Z. Ouyang, “Data processing for 3D mass spectrometry imaging”, Journal of the American Society of Mass Spectrometry, 2012, 23, 1147 – 1156 PMID: 22392622
  66. V. Pirro, L.S. Eberlin, P. Oliveri, R.G. Cooks, “Interactive hyperspectral approach for exploring and interpreting DESI-MS images of cancer and normal tissue sections”, Analyst, 2012, 137, 2374 – 2380 PMID: 22493773
  67. C.R. Ferreira, L.S. Eberlin, J.E. Hallett, R.G. Cooks, "Single oocyte and single embryo lipid analysis by desorption electrospray ionization mass spectrometry", J. of Mass Spectrometry, 2012, 47, 28-32 PMID: 22282086
  68. L.S. Eberlin, X. Liu, C.R. Ferreira, S. Santagata, N.Y.R. Agar, R.G. Cooks, "Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections", Analytical Chemistry, 2011, 83, 8366-8371 PMID: 21975048
  69. L.S. Eberlin, C.R. Ferreira, A.L. Dill, L.Cheng and R.G. Cooks, "Non-Destructive, Histologically Compatible Tissue Imaging by Desorption Electrospray Ionization Mass Spectrometry", ChemBioChem, 2011, 12, 2129 -2132 PMID: 21793152
  70. A.L. Dill, L.S. Eberlin, A.B. Costa, D.R. Ifa, R.G. Cooks, "Data Quality in Tissue Analysis using Desorption Electrospray Ionization", Analytical and Bioanalytical Chemistry, 2011, 401, 1949 -1961 PMID: 21789488
  71. L.S. Eberlin, C.R. Ferreira, A.L. Dill, D.R. Ifa, R.G. Cooks, “Desorption Electrospray Ionization Mass Spectrometry for Lipid Characterization and Biological Tissue Imaging”, Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 2011, 1811, 946 -960 PMID: 21645635
    T.A. Masterson, A.L. Dill, L.S. Eberlin, M.Mattarozzi, L. Cheng, S.D. W. Beck, F. Bianchi, R.G. Cooks, "Distinctive Glycerophospholipid Profiles of Human Seminoma and Adjacent Normal Tissues by Desorption Electrospray Ionization Imaging Mass Spectrometry", Journal of the American Society of Mass Spectrometry, 2011, 22, 1326-1333 PMID: 21953186
  72. D.R. Ifa, A. Srimany, L.S. Eberlin, H.R. Naik, V. Bhat, R.G. Cooks, T. Pradeep, "Tissue Imprint Imaging by Desorption Electrospray Ionization Mass Spectrometry", Analytical Methods, 2011, 3, 1910-1912
    A.L. Dill, L.S. Eberlin, A.B. Costa, C. Zheng, D.R. Ifa, L. Cheng, T.A. Masterson, M.O. Koch, O. Vitek, and R.G. Cooks, "Statistical Classification of Human Bladder Carcinomas using Ambient Ionization Imaging Mass Spectrometry", Chemistry-A European Journal, 2011, 17, 2897–2902 PMID: 21284043
  73. L.S. Eberlin, A.L. Dill, A.J. Golby, K.L. Ligon, J.M. Wiseman, R.G. Cooks, N.Y. R. Agar, "Discrimination of Human Astrocytoma Subtypes by Lipid Analysis using Desorption Electrospray Ionization Imaging Mass Spectrometry", Angewandte Chemie International Edition, 2010, 49, 5953-5956 PMID: 20602384
  74. L.S. Eberlin, R. Haddad, R.C.S. Neto, R.G. Cosso, D.R.J. Maia, A.O. Maldaner, J.J. Zacca, G.B. Sanvido, W. Romao, B.G. Vaz, D.R. Ifa, A.L. Dill, R.G. Cooks, M.N. Eberlin, “Instantaneous Chemical Profiles of Banknotes by Ambient Mass Spectrometry”, Analyst, 2010, 135, 2533-2539 PMID: 20593076
  75. A.L. Dill, L.S. Eberlin, C. Zheng; A.B. Costa; D.R. Ifa; L. Cheng; T.A. Masterson; M.O. Koch; O. Vitek; R.G. Cooks, "Statistical Differentiation of Renal Cell Carcinomas based on Lipidomic Analysis by Ambient Ionization Imaging Mass Spectrometry", Analytical and Bioanalytical Chemistry, 2010, 398, 2969-2978 PMID: 20953777
  76. R.G. Cooks, N.E. Manicke, A.L. Dill, D.R. Ifa, L.S. Eberlin, A.B. Costa, H. Wang, G. Huang, Z. Ouyang, "New ionization methods and miniature mass spectrometers in biomedicine: DESI imaging for cancer diagnostics and paper spray ionization for therapeutic drug monitoring", Faraday Discussions, 2010, 149, 247-267 PMID: 21413184
  77. L.S. Eberlin, A.L. Dill, A.B. Costa, D.R. Ifa, L.Cheng, T.Masterson, M.Koch, T.L. Ratliff, and R.G. Cooks, "Cholesterol Sulfate Imaging in Human Prostate Cancer Tissue by Desorption Electrospray Ionization Mass Spectrometry", Analytical Chemistry, 2010, 82, 3430-3434 PMID: 20373810
  78. L.S. Eberlin, D.R. Ifa, C.Wu, R.G. Cooks, "Three-Dimensional Visualization of Mouse Brain by Lipid Analysis Using Ambient Ionization Mass Spectrometry", Angewandte Chemie International Edition, 2010, 49, 873-876 PMID: 20041465
    A.L. Dill, L.S. Eberlin, D.R. Ifa and R.G. Cooks, "Perspectives in Imaging using Mass Spectrometry", Chemical Communications, 2010, 47, 2741 -2746 PMID: 21161110
  79. P. Albors, L.D. Slep, L.S. Eberlin, Y.E. Corilo, M.N. Eberlin, G. Bentez, M.E. Vela, R.C. Salvarezza and L.M. Baraldo, "From Monomers to Geometry-Constrained Molecules: One Step Further Toward Cyanide Bridged Wires", Inorganic Chemistry, 2009, 48, 11226-11235 PMID: 19943693
  80. L.S. Eberlin, P.V. Abdelnur, A. Passero, G.F. de Sa, R.J. Daroda, V. Souza and M.N. Eberlin, "Analysis of biodiesel and biodiesel–petrodiesel blends by high performance thin layer chromatography combined with easy ambient sonic-spray ionization mass spectrometry", Analyst, 2009, 134, 1652-1657 PMID: 20448934
  81. L.S. Eberlin, Y. Xia, H. Chen and R.G. Cooks, "Atmospheric Pressure Thermal Dissociation of Phospho- and Sulfopeptides", Journal of the American Society of Mass Spectrometry, 2008, 19, 1897-1905 PMID: 18722138
  82. P.V. Abdelnur, L.S. Eberlin, G.F. de Sá, V.Souza and M.N. Eberlin, "Single-Shot Biodiesel analysis: Nearly Instantaneous Typification and Quality Control Solely by Ambient Mass Spectrometry", Analytical Chemistry, 2008, 80, 7882-7886 PMID: 18808154
  83. M. Benassi, L.A.B. Moraes, L.G. Cabrini, L.C. Dias, A.M. Aguilar, G.A. Romeiro, L.S. Eberlin, M.N. Eberlin. "Recognition of cyclic, acyclic, exocyclic, spiro acetals via structurally diagnostic ion/molecule reactions with the (CH3)2N-C+=O acylium ion", Journal of Organic Chemistry, 2008, 73, 5549-5557 PMID: 18570407
  84. H. Chen, L.S. Eberlin, M. Nefliu, R. Augusti, R.G. Cooks, "Organic Reactions of Ionic Intermediates Promoted by Atmospheric-Pressure Thermal Activation", Angewandte Chemie International Edition, 2008, 47, 3422-3425 PMID: 18357600
  85. H. Chen, L.S. Eberlin and R.G. Cooks, "Neutral Fragment Mass Spectra after Ambient Thermal Dissociation of Peptide and Protein Ions", Journal of the American Chemical Society, 2007, 129, 5880-5886 PMID: 17432855
  86. D.R. Ifa, L. Gumaelius, L.S. Eberlin, N.E. Manicke and R.G. Cooks, "Forensic Analysis of Inks by Imaging Desorption Electrospray Ionization Mass Spectrometry", Analyst, 2007, 132, 461-467 PMID: 17471393
  87. A.H. Junior, L. Firn, A.J. Bortoluzzi, B.Szpoganicz, M.S. Silva, M.A. Novak, M.B. Neto, L.S. Eberlin, R.R. Catharino, M.N. Eberlin, C.Fernandes. "Solid state and solution characterization of a new dinuclear nickel (II) complex: The search for synthetic models for urease", Journal of Molecular Structure, 2006, 797, 154-164
  88. R. Sparrapan, L.S. Eberlin, R. Haddad, R.G. Cooks, M.N. Eberlin and R. Augusti, "Ambient Eberlin Reactions via Desorption Electrospray Ionization", Journal of Mass Spectrometry, 2006, 41, 1242 -1264 PMID: 16888754
  89. R. Augusti, H. Chen, L.S. Eberlin, M. Nefliu and R.G. Cooks, "Atmospheric pressure Eberlin transacetalization reactions in the heterogeneous liquid/gas phase", International Journal of Mass Spectrometry, 2006, 253, 281-287 PMID: 34916525