Hui Zheng Lab

Hui Zheng Lab Publications







  • Yang, L., Wang, Z., Wang, B., Justice, N., and Zheng, H.  (2009). Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity.  J. Neurosci., 29: 15660-15668.
  • Shelton, C.C., Zhu, L., Chau, D., Yang, L., Wang, R., Djaballah, H., Zheng, H., and Li, Y.-M. (2009). Modulation of γ-secretase specificity using small molecule allosteric inhibitors. Proc. Natl. Acad. Sci. USA, 106: 20228-20233.
  • Wang, Z., Wang, B., Yang, L., Guo, Q., Aithmitti, N., Songyang, Z. and Zheng, H.  (2009). Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J. Neurosci., 29:10788-10801. Selected as a “This Week in the Journal” article.
  • Kallhoff-Munoz, V., Hu, L., Chen, X. Pautler, R.G. and Zheng, H. (2008). Genetic dissection of γ-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J. Neurosci., 28:11421-11431.
  • Yang, L., Wang, B. Long, C., Wu, G. and Zheng, H. (2007). Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses. Neuroscience, 149: 768-778.
  • Wang, B., Yang, L., Wang, Z. and Zheng, H. (2007). Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc. Natl. Acad. Sci. USA, 104: 14140-14145.
  • Kallhoff, V., Peethumnongsin, E. and Zheng, H. (2007). Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer’s disease. Mol. Neurodegeneration, 2:6.
  • Wang, R., Wang, B., He, W., and Zheng, H. (2006). Wild-type presenilin protects against Alzheimer’s disease mutation-induced amyloid pathology. J. Biol. Chem., 281: 15330-15336.
  • Deng, Y., Tarassishin, L., Kallhoff, V., Peethumnongsin, E., Wu, L., Li, Y. and Zheng, H. (2006). Deletion of presenilin 1 hydrophilic loop sequence leads to impaired -secretase activity and exacerbated amyloid pathology. J. Neurosci. 26: 3845-3854.
  • Wang, R., Tang, P., Wang, P., Boissy, R.E. and Zheng, H. (2006). Regulation of tyrosinase trafficking and processing by presenilins: Partial loss of function by familial Alzheimer’s disease mutation. Proc. Natl. Acad. Sci. USA 103: 353-358.
  • Wang, P., Yang, G., Mosier, D.R., Chang, P., Zaidi, T., Gong, Y.-D., Zhao, N.-M., Dominguez, B., Lee, K.-F., Gan, W.-B. and Zheng, H. (2005). Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2. J. Neurosci. 25: 1219-1225.
  • Wang, R., Dineley, K.T., Sweatt, J.D, and Zheng, H. (2004). Presenilin 1 Alzheimer’s disease mutation leads to impaired adult neurogenesis and defective associative learning. Neuroscience 126: 305-312.
  • Qyang, Y., Chambers, S.M., Wang, P., Xia, X., Chen, X., Goodell, M.A. and Zheng, H. (2004). Myeloproliferative disease in mice with reduced presenilin gene dosage: Effect of -secretase blockage. Biochemistry 43: 5352-5359.
  • Wang, P., Pereira, F. A., Beasley, D., and Zheng, H. (2003). Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development 130: 5019-5029.
  • Kang, D.E., Soriano, S., Xia, X., Eberhart, C.G., De Strooper, B., Zheng, H., and Koo, E.H. (2002). Presenilin couples the paired phosphoryllation of -catenin independent of axin: Implications for -catenin activation in tumorigenesis. Cell 110: 751-762.
  • Xia, X., Wang, P., Sun, X., Soriano, S., Shum, W.-K., Trumbauer, M.E., Takashima, A., Koo, E.H., and Zheng, H. (2002). The aspartate-257 of presenilin 1 is indispensable for mouse development and production of -amyloid peptides through -catenin independent mechanisms. Proc. Natl. Acad. Sci. USA 99: 8760-8765.
  • Dineley, K.T., Xia, X., Bui, D., Sweatt, J.D., and Zheng, H. (2002). Accelerated plaque accumulation, associative learning deficits and up-regulation of 7 nicotinic acetylcholine receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem. 277: 22768-22780.
  • Xia, X., Qian, S., Soriano, S., Wu, Y., Fletcher, A., Wang, X.-J., Koo, E.H., Wu, X., and Zheng, H. (2001). Loss of presenilin 1 is associated with enhanced -catenin signaling and skin tumorigenesis. Proc. Natl. Acad. Sci. USA 98: 10863-10868.