Positions
- Associate Professor
-
Medicine-Cardiovascular Sciences
Baylor College of Medicine
Houston, TX US
Education
- Ph.D. from University Of Texas Health Science Center
- 01/1980 - Dallas, TX United States
- Post-doctoral Fellowship from Washington University School Of Medicine
- 01/1985 - St. Louis, MO United States
- M.A., magna cum laude from Texas Woman's University
- 01/1969 - Denton, Texas United States
- B.A., magna cum laude from University Of Dallas
- 01/1965 - Irving, Texas United States
Professional Statement
Dr. Trial is studying the origins of different types of fibroblasts in healing injuries to the heart. This research is in two major areas: a) White blood cells called monocytes travel through the blood and migrate to organs that have been injured. The cells migrate out of the blood vessels and into these tissues, where they mature either into macrophages that fight infections, or fibroblasts that form scars. We have identified some of the factors that influence the decision of the monocyte to become either a macrophage or a fibroblast, and are investigating the signaling mechanisms and cascades that result. b) Fibroblasts are cells that can deposit scars after tissue injury. Some of these cells derive from adult stem cell progenitors in the heart. The stem cells are multipotent in that they can develop into many kinds of cells such as bone, cartilage, and fat cells as well as fibroblasts. We are studying which influences determine the lineage choice of these cells.Websites
Selected Publications
- Trial, J., Diaz-Lankenau, R., Angelini, A., Tovar-Perez, J.E., Taffet, G.E., Entman, M.L., Cieslik, K.A. "Treatment with a DC-SIGN ligand reduces macrophage polarization and diastolic dysfunction in the aging female but not male mouse hearts.." Geroscience. 2021 April ; 43 (2): 881-899. Pubmed PMID: 32851570
- Angelini A, Trial J, Ortiz-Urbina J, Cieslik KA. "Mechanosensing dysregulation in the fibroblast: A hallmark of the aging heart.." Ageing Res Rev. 2020 63 : 101150; doi: 10.1016/j.arr.2020.101150. Pubmed PMID: 32846223
- Trial, J. and Cieslik, K.A. "Changes in cardiac resident fibroblast physiology and phenotype in aging.." Am J Physiol Heart and Circ Physiol. 2018 315 (4): H745-H755. Pubmed PMID: 29906228
- Cieslik, K.A., Trial, J., Entman, M.L. "Aicar Treatment Reduces Interstitial Fibrosis In Aging Mice. Suppression of the Inflammatory Fibroblast.." J Mol Cell Cardiol. 2017 111 : 81-85. Pubmed PMID: 28826664
- 3. Trial, J., Pena Heredia, C., Taffet, G.E., Entman, M.L., Cieslik, K.A. "Dissecting the Role of Myeloid and Mesenchymal Fibroblasts in Age-dependent Cardiac Fibrosis.." Basic Res Cardiol. 2017 112 (4): 34. Pubmed PMID: 28478479
- Trial, J., Potempa, L.A., Entman, M.L. "The role of C-reactive protein in innate and acquired inflammation: New perspectives.." Inflamm Cell Signal. 2016 3 : e1409. Pubmed PMID: 27738646
- Crawford, J.R., Trial, J., Nambi, V., Hoogeveen, R.C., Taffet, G.E., Entman, M.L. "Plasma Levels of Endothelial Microparticles Bearing Monomeric C-reactive Protein Are Increased in Peripheral Artery Disease.." J Cardiovasc Transl Res. 2016 9 (3): 184-193. Pubmed PMID: 26891844
- Trial, J., Cieslik, K.A., Entman, M.L. "Phosphocholine-containing ligands direct CRP induction of M2 macrophage polarization independent of T cell polarization: Implication for chronic inflammatory states.." Immun Inflamm Disease. 2016 4 (3): 274-288. Pubmed PMID: 27621811
- Trial, J., Entman, M., Cieslik, K.A. "Mesenchymal stem cell-derived inflammatory fibroblasts mediate interstitial fibrosis in the aging heart.." J Mol Cell Cardiol. 2016 February ; 91 : 28-34. Pubmed PMID: 26718722
- Cieslik, K.A., Trial, J., Entman, M.L. "Mesenchymal stem cell-derived inflammatory fibroblasts promote monocyte transition into myeloid fibroblasts via an IL-6-dependent mechanism in the aging mouse heart.." FASEB J. 2015 29 (8): 3160-3170. Pubmed PMID: 25888601
- Duerrschmid, C., Trial, J., Wang, Y., Entman, M.L., Haudek, S.B. "Tumor Necrosis Factor: A Mechanistic Link Between Angiotensin-II-induced Cardiac Inflammation and Fibrosis.." Circ Heart Failure. 2015 8 : 352-361. Pubmed PMID: 25550440
- 6. Cieslik, K.A., Trial, J., Crawford, J.R., Taffet, G.E., Entman, M.L. "Adverse fibrosis in the aging heart depends on signaling between myeloid and mesenchymal cells; role of inflammatory fibroblasts.." J Mol Cell Cardiol. 2014 70 : 56-63. Pubmed PMID: 24184998
- Cieslik KA, Trial J, Carlson S, Taffet GE, Entman ML "Aberrant differentiation of fibroblast progenitors contributes to fibrosis in the aged murine heart: role of elevated circulating insulin levels.." FASEB J.. 2013 April ; 27 (4): 1761-71. Pubmed PMID: 23303205
- 4. Cieslik, K.A., Crawford, J.R., Taffet, G.E., Trial, J., Mejia-Osuna, P., Entman, M.L. "AICAR-dependent AMPK Activation Improves Scar Formation in the Aged Heart in a Murine Model of Reperfused Myocardial Infarction.." J Mol Cell Cardiol. 2013 July ; 63C : 26-36. Pubmed PMID: 23871790
- Yang, J., Lin, S.C., Chen,G., He, L., Hu, Z., Chan, L., Trial, J., Entman, M.L., Wang Y. "Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis.." J Am Soc Nephrol. 2013 October 24; 10 : 1644-1659. Pubmed PMID: 23833260
- Trial, J., Cieslik, K.A., Haudek, S.B., Duerrschmid, C. and Entman, M.L. "Th1/M1 conversion to Th2/M2 responses in models of inflammation lacking cell death stimulates maturation of monocyte precursors to fibroblasts.." Front Immunol. 2013 September ; 4 (287): Pubmed PMID: 24065967
- Duerrschmid C, Crawford JR, Reineke E, Taffet GE, Trial J, Entman ML, Haudek SB "TNF receptor 1 signaling is critically involved in mediating angiotensin-II-induced cardiac fibrosis.." J. Mol. Cell. Cardiol.. 2013 April ; 57 : 59-67. Pubmed PMID: 23337087
- Crawford JR, Haudek SB, Cieslik KA, Trial J, Entman ML "Origin of Developmental Precursors Dictates the Pathophysiologic Role of Cardiac Fibroblasts.." J Cardiovasc Transl Res. 2012 September 13; : Pubmed PMID: 22972312
- Carlson S, Trial J, Soeller C, Entman ML "Cardiac mesenchymal stem cells contribute to scar formation after myocardial infarction.." Cardiovasc. Res.. 2011 July 1; 91 (1): 99-107. Pubmed PMID: 21357194
- Cieslik KA, Taffet GE, Carlson S, Hermosillo J, Trial J, Entman ML "Immune-inflammatory dysregulation modulates the incidence of progressive fibrosis and diastolic stiffness in the aging heart.." J. Mol. Cell. Cardiol.. 2011 January ; 50 (1): 248-56. Pubmed PMID: 20974150
- Cieslik KA, Trial J, Entman ML "Defective Myofibroblast Formation from Mesenchymal Stem Cells in the Aging Murine Heart Rescue by Activation of the AMPK Pathway.." Am. J. Pathol.. 2011 October ; 179 (4): 1792-806. Pubmed PMID: 21819956
Memberships
- Society for Leukocyte Biology
- Member
- American Association of Immunologists
- Member
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