Microbial infection is a complex process involving host invasion by the microbe, evasion of host defenses, and survival and replication of the microbe. At each stage, pathogens may exploit or subvert the host processes that can result in disease. Insights into how microbes interact with host cells and tissues and identification of the mechanisms by which pathogens cause disease is essential to developing treatments that reduce or cure the illness and death they cause.

Faculty and trainees in the host-microbe interactions and pathogenesis research area study all levels of microbe-host interactions, including mechanisms of host invasion, regulation of host physiology and cellular function, animal models of disease, and studies with humans. We exploit advanced in vitro model systems that recapitulate human disease and characterization of altered host pathways to identify targets to eliminate the pathogen or reduce disease severity. Our group studies a wide array of viral and bacterial pathogens, fungi and microbial parasites, as well as commensal host-microbe interactions that influence pathogenesis.

This research is supported by the Alkek Center for Metagenomics and Microbiome Research (CMMR), the Texas Medical Center Digestive Diseases Center, the Biology of Inflammation Center, the Center for Comparative Medicine, and cores through the BCM Advanced Technology Cores.

A-K: Profiles of Faculty Working on Host-Microbe Interactions and Pathogenesis

Robert Legare Atmar, M.D.

Professor

Phone

  • (713) 798-6849

Respiratory viral pathogens; Enteric viruses and environmental virology

David B. Bates

Associate Professor

Phone

  • (713) 798-7747

Chromosome dynamics, molecular mechanisms of DNA replication, and cell cycle control in E. coli

Maria Elena Bottazzi, Ph.D.

Associate Dean, National School of Tropical Medicine

Phone

  • (832) 824-0510

Robert Allen Britton, Ph.D.

Professor

Therapeutic microbiology, probiotics, genomics and genetics of the human microbiota

Douglas G Burrin, Ph.D.

Research Physiologist

Phone

  • (713) 798-7049

Margaret Ellen Conner, Ph.D.

Associate Professor

Phone

  • (713) 798-3590

Pathogenesis of and immunity to enteric pathogens

David B Corry, M.D.

Professor

Phone

  • (713) 798-7313

Asthma; Cytokine receptors; T cells; Airway physiology; Proteases

Gretchen Diehl, Ph.D.

Assistant Professor

Impact of the microbiota on intestinal immune responses

Tony Eissa, M.D.

Professor

Phone

  • (713) 798-3190

Regulation of Autophagy in Innate Immunity; Cellular Regulation of Nitric Oxide Synthesis in Inflammation; Cellular regulation of misfolded proteins

Mary K. Estes, Ph.D.

Distinguished Service Professor

Phone

  • (713) 798-3585

Human mini-gut cultures to understand gastrointestinal virus-host interactions and mechanisms of pathogenesis and immunity

Christophe Herman, Ph.D.

Professor

Phone

  • (713) 798-2126

Epigenetic inheritance and phenotypic variability

Peter Jay Hotez, M.D., Ph.D.

Dean for the National School of Tropical Medicine

Phone

  • (713) 798-1199

Drug and Vaccine Delivery; Tropical Medicine

Joseph Michael Hyser, Ph.D.

Assistant Professor

Phone

  • (713) 798-4514

Enteric Virus Calcium Channel Blockers; Exploitation of Host Calcium Signaling Pathways by Microbes…

Kathryn Marie Jones, D.V.M., Ph.D.

Assistant Professor

Farrah Kheradmand, M.D.

Professor

Phone

  • (713) 798-8622

Immune cells and lung disease; Matrix metalloproteinases; Cytokine function

Jason Thomas Kimata, PH.D.

Associate Professor

Phone

  • (713) 798-4536

HIV Replication, Pathogenesis, and Cure

Katherine Yudeh King, M.D., Ph.D.

Associate Professor

Role of interferon-gamma in hematopoietic stem cell regulation

L-Z: Profiles of Faculty Working on Host-Microbe Interactions and Pathogenesis

Ann Marie Leen, Ph.D.

Assistant Professor

Phone

  • (832) 824-4690

T cell immunotherapy for viruses and cancer

Paul Dalling Ling, Ph.D.

Associate Professor

Phone

  • (713) 798-8474

Elephant Endotheliotropic Herpesvirus (EEHV); Gammaherpesvirus pathogenesis

Job E. Lopez, Ph.D.

Assistant Professor

Anthony Maresso, Ph.D.

Associate Professor

Phone

  • (713) 798-7369

Pathogenesis of bacterial infections

Pedro A. Piedra, M.D.

Professor

Phone

  • (713) 798-5240

Reduction of respiratory virus illness burden in infants

Robert Franklin Ramig, Ph.D.

Professor

Phone

  • (713) 798-4830

Phage Therapy for Human Infections; Genetics of viral replication and pathogenesis

Andrew Patrick Rice, Ph.D.

Professor

Phone

  • (713) 798-5774

Viral gene expression

Rebecca Rico-Hesse, Ph.D., M.P.H.

Professor

Phone

  • (713) 798-3010

Pathogenesis of mosquito-transmitted viruses

Cliona M Rooney, Ph.D.

Professor

Phone

  • (832) 824-4693

Virus-specific T cells for treatment of viral diseases

Buck Samuel, Ph.D.

Assistant Professor

Phone

  • (713) 798-9110

Microbiome programming of host physiology and development; Genetics and genomics of host-microbe interactions…

Michael Scheurer, Ph.D., M.P.H.

Professor

Gad Shaulsky, Ph.D.

Professor

Phone

  • (713) 798-8082

Functional Genomics and Transcriptome analysis; The evolution of social behavior in Dictyostelium; Allorecognition in Dictyostelium…

Betty L. Slagle, Ph.D.

Associate Professor

Phone

  • (713) 798-3006

Pathogenesis of viral hepatitis

Francis T.F. Tsai, D.Phil.

Professor

Phone

  • (713) 798-8668

Protein Structure-Function and Protein Folding; Structural Biology and Macromolecular Assemblies; Cryo-electron Microscopy and Tomography…

Laila E. Woc-Colburn, M.D., DTM&H, FACP, FIDSA

Associate Professor & Director of Medical Education

Phone

  • (713) 798-2900

Tropical Medicine; HIV/AIDS patient care; Medical Education; Endovascular infections; Fungal infections; Non-Tuberculous mycobacterium