Innovative approaches to developing novel and specifically targeted clinical therapies for immunologic, allergic and rheumatologic diseases is the primary mission of research conducted among both clinical and research faculty and staff within the Division of Immunology, Allergy and Rheumatology and the Center for Human Immunobiology.
Allergy and Immunology
As part of the nationwide International Maternal, Pediatric, Adolescent AIDS Clinical Trials (IMPAACT) Network sponsored by the National Institutes of Health, the Section of Allergy and Immunology provides a variety of research and treatment options for infants, children and adolescents with HIV infection. We conduct basic science, as well as clinical trials research for pregnant women and children with HIV infection in collaboration with other Baylor College of Medicine researchers and other national institutions.
Allergy and Immunology is also pleased to offer cutting-edge research and clinical trials in food allergy through our Texas Children's Hospital Food Allergy program led by Dr. Carla Davis.
For more information, view grants, and selected allergy and immunology publications.
Center for Human Immunobiology
As a central hub with bi-directional spokes emanating throughout Texas Children's Hospital and Baylor, Texas Children's Center for Human Immunobiology enables investigations and discoveries that will translate into high-impact biology and novel approaches to the diagnosis and treatment of pediatric disease.
The overarching goal is to create essential synergy with existing emphasis centers in genetics/genomics, international medicine and cellular therapy so that the TECHCHI will develop into a key ingredient in uniquely accelerating discovery and innovation at Texas Children's and Baylor.
Visit the pages of our center research faculty, Dr. Carla McGuire Davis for further details.
Current Grants
Title: Center for AIDS Research - Developmental Funding for Pilot and Collaboration Projects
Funding Agency: NIH-NIAID
Role: Principal Investigator
Title: International Maternal Pediatric Adolescent AIDS Clinical Trials Group
Funding Agency: NIH-NIAID
Role: Principal Investigator
Title: HIV/AIDS Cohort Study
Funding Agency: NIH-NICHD
Role: Principal Investigator
Title: Pediatric HIV/AIDS Cohort Study (Adolescent Master Protocol Study)
Funding Agency: NIH-NICHD
Role: Principal Investigator
Title: Center for AIDS Research - Clinical (Core E)
Funding Agency: NIH-NIAID
Role: Core Director
Title: Training Program for Clinical Research on AIDS
Funding Agency: NIH-NIAID
Role: Program Director
Title: Eosinophil Proteome Analysis in Eosinophilic Esophagitis
Funding Agency: Texas Children's Hospital Pediatrics Pilot Research Fund
Role: Principal Investigator
Title: Phase 1 Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
Funding Agency: NIH-NCCAM
Role: Principal Investigator
Title: Methionine Aminopeptidases as Novel Targets for Tuberculosis and HIV Co-Infection
Funding Agency: CFAR
Role: Co-Principal Investigator
Title: Kids Council-Caregivers League - Needs Assessment of a Youth-Founded Educational Network, Baylor College of Medicine
Funding Agency: The Auxiliary of Texas Children's Hospital
Role: Principal Investigator
Intent to Submit Proposal for Funding
The Intent to Submit form facilitates efficient, time-saving communication between the PI and members of the Section Research Administration Team for budgeting, routing, editing and other support.
Publications
Stephen B, Hajjar J. Overview of Basic Immunology and Translational Relevance for Clinical Investigators. Adv Exp Med Biol. 2018;995:1-41. doi: 10.1007/978-3-030-02505-21. PMID: 30539504
Anagnostou K, Turner PJ. Myths, facts and controversies in the diagnosis and management of anaphylaxis. Arch Dis Child. 2019 Jan;104(1):83-90. doi: 10.1136/archdischild-2018-314867. Epub2018 Jun 16. Review. PMID: 29909382
Anagnostou K. Food immunotherapy for children with food allergies: state of the art and science. Curr Opin Pediatr. 2018 Dec;30(6):798-805. doi: 10.1097/MOP.0000000000000684. PMID: 30157046
Anagnostou A. Insights into tree nut and sesame consumption from a cohort of 80 peanut-allergic children. Pediatr Allergy Immunol. 2018 Dec 27. doi: 10.1111/pai.13016.
Anvari S, Blackman AC, Anagnostou A. Insights from 275 Cases of Childhood Anaphylaxis in the United States. J Allergy Clin Immunol Pract. 2018 Dec 21. pii: S2213-2198(18)30835-3. doi: 10.1016/j.jaip.2018.12.013.
Deniskin, R., Sasa, GS., Nandiwada, SL., and Rider, NL. “Lymphopenia with Clinical and Laboratory Features of Combined Immune Deficiency in an 11-Year-Old Female with FANCD2 Variants and Fanconi Anemia.” Front. Pediatr. 18 Jan 2019.
Carla Perez, Madelyn Richards, Munazza Noor, Kristen Staggers, Charles Minard, Carla Davis, Anthony Olive. Eosinophilic Esophagitis Reference Score Can Identify Pediatric Patients with Eosinophilic Esophagitis. J Allergy Clin Immunol. Vol. 143, Issue 2, AB137.
Carla Davis, Todd David Green, Romain Lambert, David Fleischer. Efficacy and Safety of Epicutaneous Immunotherapy for Peanut Allergy in Subjects With and Without Atopic Dermatitis. J Allergy Clin Immunol. Vol. 143, Issue 2, AB242.
Munazza Noor, Sara Anvari, Anthony Olive, Lauren Kronisch, Carla Davis. The Prevalence of IgE-Mediated Peanut Allergy in Patients Diagnosed with Eosinophilic Esophagitis. J Allergy Clin Immunol. Vol. 143, Issue 2, AB139.
Sara Anvari, Levi Watkin, Victor Cardenas, Oluwatomi Hassan, Carla Davis. Dendritic Cell Frequencies are Early Markers of Desensitization in Peanut Oral Immunotherapy. J Allergy Clin Immunol. Vol. 143, Issue 2, AB246.
Daisy Tran, Charles Minard, Kristen Staggers, Chivon McMullen-Jackson, Fabian Rivera, Sara Anvari, Carla Davis. School Personnel Apprehension Related To Stock Epinephrine In Greater Houston Area. J Allergy Clin Immunol. Vol. 143, Issue 2, AB76.
Vibha Szafron, Sara Anvari, Ariel Washington, Carla Davis. Improvement in Quality of Life (QOL) in Pediatric Patients with Food Allergy Associated Disease After Initial Clinic Evaluation. J Allergy and Clin Immunol. Vol. 143, Issue 2, AB84.
Karen Tuano, Sara Anvari, Joud Hajjar, Filiz Seeborg, Lenora Noroski, Jordan Orange, Carla Davis. Hemocyanin Is A Shrimp Allergen In The U.S.: Clinical And Immunological Profiles Of Food Challenge-Proven Shrimp Allergic Patients. J Allergy Clin Immunol. Vol. 143, Issue 2, AB239.
Kathleen Pitts, Theresa Aldape, Daisy Tran, Sara Anvari, Aikaterini Anagnostou, Lauren Kronisch, Larraine Lyter-Reed, Carla Davis. A Community Voice for Food Allergy Families: A Four-Year Successful Educational Experience. J Allergy Clin Immunol. Vol. 143, Issue 2, AB72.
Irit Tirosh, Yasuhiro Yamazaki, Francesco Frugoni, Francesca A. Ververs, Eric J. Allenspach, Yu Zhang, Siobhan Burns, Waleed Al-Herz, Lenora Noroski, Jolan E. Walter, Andrew R. Gennery, Mirjam van der Burg, Luigi D. Notarangelo, and Yu Nee Lee. “Recombination activity of human recombination-activating gene 2 (RAG2) mutations and correlation with clinical phenotype”. J Allergy Clin Immunol. 2019 143(2): 727-735.
Fabre A, Marchal S, Barlogis V, Mari B, Barbry P, Rohrlich P-S, Forbes LR, Vogel TP*, Giovannini-Chami L*. Clinical aspects of STAT3 gain-of-function germline mutations: a systematic review. JACI: In Practice. 2019 (in press, *co-senior author)
Kurkowski J, Jayer JE, Sangi H, Curry M, de Guzman M, Hakim J. Contraceptive and Reproductive Care in Patients with SLE. Women’s Healthc. 2019 (accepted for publication)
Martinez C, Aguayo-Hiraldo PI, Rider NI, Nicholas SK, Forbes L, Seeborg FO, Noroski LM, Hanson IC, Omer B, John T, Yassine K. Excellent Outcomes for Pediatric Non-Malignant Diseases Using Umbilical Cord Blood Transplantation (UCBT) Conditioned without Serotherapy in the Absence of a Matched Related Donor. Biol Blood Marrow Transplant. 2019 Mar 1;25(3):S13.
Lyter-Reed LL, Hajjar J, Noroski LM. Scombroid Poisoning versus Crab Food Allergy in an Adolescent Patient. J Allergy Clin Immunol. 2019 Feb 1;143(2):AB74.
Tuano KT, Anvari S, Hajjar J, Seeborg FO, Noroski LM, Orange JS, Davis CM. Hemocyanin Is A Shrimp Allergen In The US: Clinical And Immunological Profiles of Food Challenge-Proven Shrimp Allergic Patients. J Allergy Clin Immunol. 2019 Feb 1;143(2):AB239.
Lenora Noroski, M.D., M.P.H., Shailendra Das, D.O., Joud Hajjar, M.D. Correspondence in Case Records #40-2018 of the Massachusetts General Hospital: A Woman with Recurrent Sinusitis, Cough, and Bronchiectasis. N Engl J Med. 2019 (accepted for publication). Names not changed to conform to the others on this section because this is how they appear in the publication.
Rider, NL, Miao, D., Dodds, M., Modell, V, Modell, F, Quinn, J, Schwarzwald,H, and Orange, JS. “Calculation of a Primary Immunodeficiency “Risk Vital Sign” via Population-Wide Analysis of Claims Data to Aid in Clinical Decision Support.” Front. Pediatr. March 19, 2019.
Anagnostou A, Anvari S, Blackman A. Insights into Infant Anaphylaxis. J Allergy Clin Immunol. Vol 143, Issue 2, AB154.
Ekta Kakkar and Joud Hajjar. “Primary Immunodeficiencies in Pregnancy”, in the Asthma, Allergic and Immunologic Diseases During Pregnancy: A Guide to Management. https://link.springer.com/chapter/10.1007/978-3-030-03395-8_11. Names not changed to conform to the others on this section because this is how they appear in the publication.
Chaimowitz NS, Branch J, Reyes A, Vargas-Hernandez A, Orange JS, Forbes LR, Ehlayel M, Purayil SC, Ali Al-Nesf M, Vogel TP. A novel STAT3 mutation in a Qatari patient with hyper-IgE syndrome. Front Pediatr. 2019 (in press).
Fleischer DM, Greenhawt M, Sussman G, Bégin P, Nowak-Wegrzyn A, Petroni D, Beyer K, Brown-Whitehorn T, Hebert J, Hourihane JO, Campbell DE, Leonard S, Chinthrajah RS, Pongracic JA, Jones SM, Lange L, Chong H, Green TD, Wood R, Cheema A, Prescott SL, Smith P, Yang W, Chan ES, Byrne A, Assa'ad A, Bird JA, Kim EH, Schneider L, Davis CM, Lanser BJ, Lambert R, Shreffler W. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 Feb 22. doi: 10.1001/jama.2019.1113.
Blackman AC, Anvari S, Davis CM, Anagnostou A. Emerging Triggers of FPIES: Lessons from a Pediatric Cohort of 74 Children in the US. Ann Allergy Asthma Immunol. 2019 Feb 8. pii: S1081-1206(19)30093-6. doi: 10.1016/j.anai.2019.01.022.
Burrage LC, Reynolds JJ, Baratang NV, Phillips JB, Wegner J, McFarquhar A, Higgs MR, Christiansen AE, Lanza DG, Seavitt JR, Jain M, Li X, Parry DA, Raman V, Chitayat D, Chinn IK, et. al. Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. Am J Hum Genet. 2019 Mar 7;104(3):422-438. doi: 10.1016/j.ajhg.2019.01.007. Epub 2019 Feb 14.
Volpi S, Cicalese MP, Tuijnenburg P, Tool ATJ, Cuadrado E, Abu-Halaweh M, Ahanchian H, Alzyoud R, Akdemir ZC, Barzaghi F, Blank A, Boisson B, Bottino C, Brigida I, Caorsi R, Casanova JL, Chiesa S, Chinn IK, Dückers G, Enders A, Erichsen HC, Forbes LR, Gambin T, Gattorno M, Karimiani EG, Giliani S, Gold MS, Jacobsen EM, Jansen MH, King JR, Laxer RM, Lupski JR, Mace E, Marcenaro S, Maroofian R, Meijer AB, Niehues T, Notarangelo LD, Orange J, Pannicke U, Pearson C, Picco P, Quinn PJ, Schulz A, Seeborg F, et. al. A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency. J Allergy Clin Immunol. 2019 Feb 13. pii: S0091-6749(19)30206-4. doi: 10.1016/j.jaci.2019.02.003.
Staines Boone AT, Chinn IK, Alaez-Versón C, Yamazaki-Nakashimada MA, Carrillo-Sánchez K, García-Cruz MLH, Poli MC, González Serrano ME, Medina Torres EA, Muzquiz Zermeño D, Forbes LR, et. al. Failing to Make Ends Meet: The Broad Clinical Spectrum of DNA Ligase IV Deficiency. Case Series and Review of the Literature. Front Pediatr. 2019 Jan 21;6:426. doi: 10.3389/fped.2018.00426.
Noroski L, Das S, Hajjar J. Case 40-2018: A woman with Recurrent Sinusitis, Cough and Bronchiectasis. N Engl J Med. 2019:380(14):1383.
Blackman AC, Anvari S, Davis CM, Anagnostou A. Emerging triggers of food protein-induced enterocolitis syndrome: Lessons from a pediatric cohort of 74 children in the United States. Ann Allergy Asthma Immunol. 2019 Apr;122(4):407-411.
Wright TE, Shah MD, Rider NL, Porea TJ, Musick MA, Miller J, Daves M, Foster JH, Anvari S. A case-series of pediatric oncology patients undergoing successful rapid etoposide desensitization. Pediatr Allergy Immunol. 2019 Apr 9. doi: 10.1111/pai.13059. [Epub ahead of print] PMID: 30963632
Wang HT, Anvari S, Anagnostou K. The Role of Probiotics in Preventing Allergic Disease. Children (Basel). 2019 Feb 5;6(2). PMID 30764558
Yeh CY, Wheeler A, Bethea L, Bird JA, Fulbright J, Freeman T, Gonzalez-Reyes E, Jeffrey D, Schwind K, Stafford W, Varshney P, Beard C, Davis CM. Identifying Barriers to Implementation of Emergency Epinephrine Bills: The Texas Experience. J Allergy Clin Immunol Pract. 2019 May 3. pii: S2213-2198(19)30436-2. doi: 10.1016/j.jaip.2019.04.032.
Ramsey NB, Guffey D, Anagnostou K, Coleman NE, Davis CM. Epidemiology of Anaphylaxis in Critically-Ill Children in the United States and Canada. J Allergy Clin Immunol Pract. 2019 Apr 30. pii: S2213-2198(19)30398-8. doi: 10.1016/j.jaip.2019.04.025.
Greer FR, Sicherer SH, Burks AW; COMMITTEE ON NUTRITION; SECTION ON ALLERGY AND IMMUNOLOGY:Abrams SA, Fuchs GJ 3rd, Kim JH, Lindsey CW, Magge SN, Rome ES, Schwarzenberg SJ, Matsui EC, Bird JA, Davis CM, Hernandez-Trujillo VP, Mahr TA, Orange JS, Pistiner M, Wang J, Williams PV. The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods. Pediatrics. 2019 Apr;143(4). pii: e20190281. doi: 10.1542/peds.2019-0281. Epub 2019 Mar 18.