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Molecular and Cellular Biology

Houston, Texas

Image 1: Ovulated mouse cumulus cell oocyte complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.; Image 2: By Yi LI, Ph.D.; Image 3: Mouse oocyte at meiosis I immunostained  for tubulin (red) phosphop38MAPK (green) and DNA (blue). By JoAnne Richards,  Ph.D.;  Image 4: Expanded cumulus cell ooctye ocmplex  immunostained for hyaluronan (red), TSG6 (green) and DAN (blue). By JoAnne  Richards, Ph.D.;  Image 5: Epithelial cells taken from a mouse  mammary gland were cultured in a dish and transduced with a retrovirus  expressing two genes. The green staining shows green fluorescent protein and the red  staining shows progesterone receptor expression. The nucleus of each cell is  stained blue. Photomicrograph taken at 200X magnification.  By Sandra L. Grimm,  Ph.D.; Image 6: Ovarian vasculature (red) is excluded from the granulosa cells (blue) within growing follicles (round structures); Image 7:  Ovulated mouse cumulus cell oocyte  complex immunostained for matrix proteins hyaluronan and versican. By JoAnne Richards, Ph.D.
Department of Molecular and Cellular Biology
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Gayle Slaughter, Ph.D.

Gayle Slaughter, Ph.D. photoAssociate Professor
Department of Molecular and Cellular Biology

Education

Ph.D.: Iowa State University, Ames
Postdoctoral training: Baylor College of Medicine, Houston

Research Interest

Training Programs for Scientists
My research transformed from studying how Sertoli cells create environments in which germ cells can develop into studying how we can create optimal environments in which scientists will develop the skills they need to be successful. As the director of the SMART summer undergraduate research program and the Assistant Dean for the Graduate School of Biomedical Sciences, I create and direct a series of programs to identify and nurture young scientists. BCM Ph.D. students can serve as mentors or guest lectures for these programs. More than 1,700 college students from across the nation have participated in the unique SMART Program. The SMART PREP post-bac program and three NIGMS IMSD grants targeted to under-represented Ph.D. students foster development of scientists. More than 90 under-represented Ph.D. and MD/Ph.D. students are currently enrolled at BCM. Since 1998, the 131 students in this group have won more than 100 BCM, national and international awards, including nearly 40 national fellowships. I am also the PI on a new grant that provides opportunities for BCM post-docs to learn to teach and develop courses and then teach them at Houston area minority serving undergraduate campuses. The programs I direct have been supported by grants from NIH NIGMS, NIH NHLB, NSF, DOD and private foundations including the DeBakey Medical Foundation.

I developed and present a range of skills workshops to help scientists learn how to optimize their results and time. These “Thriving, Not Just Surviving, as a Scientist” workshops have been presented for undergraduates, Ph.D. students, post-docs, medical residents and faculty at BCM and campuses and conferences across the nation. Some of the workshops have been collected in a 150 page guidebook Beyond the Beakers: SMART Advice on Entering Graduate Programs in the Sciences and Engineering, now available as a CD or as a download from http://www.bcm.edu/gradschool. I could not have imagined when I changed my model organism of study from rats to humans that I would be presented the BCM Presidential Award for Excellence in Education, the first MCB Award for Education and Service and the Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring in the Oval Office. I am using the PAESMEM Award to produce a video targeted to encourage 9th and 10th graders to take science courses and pursue science careers using our own under-represented students as role models.

Contact Information

Baylor College of Medicine
One Baylor Plaza, MS N215 DeBakey Building
Houston, TX 77030

Phone: 713-798-6644
E-mail: gayles@bcm.edu

Selected Publications

  1. Slaughter GR. (2005). Beyond the Beakers: SMART Advice on Entering Graduate Programs in the Sciences and Engineering.
  2. Slaughter GR and Aguilar-Bryan L. (2002). Under-represented Minority Faculty; Impact on Biomedical Research.
  3. Katz D, Niederberger C, Slaughter GR and Cooney AJ. (1997). Characterization of germ cell specific expression of the orphan nuclear receptor, GCNF. Endocrinology 138:4364-4372.
  4. Slaughter GR and Means AR. (1989). Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. Mol Endocrinol 3:1569-1578.
  5. Ono T, Slaughter GR, Cook RG and Means AR. (1989). Molecular cloning sequence and distribution of rat calspermin, a high affinity calmodulin binding protein. J Biol Chem 264:2081-2087.
  6. Slaughter GR, Meistrich ML and Means AR. (1989). Expression of RNAs for calmodulin, actins, and tubulins in rat testis cells. Biol Reprod 40:395-405.
  7. Slaughter GR, Needleman DS and Means AR. (1987). Developmental expression of calmodulin, tubulin and actin mRNAs in rat testis. Biol Reprod 37:1247-1258.
  8. Slaughter GR and Means AR. (1987). Use of the 125I-labeled protein gel overlay technique to study calmodulin binding proteins. In: Methods in Enzymology 139:433-444. (invited reviewed article)
  9. Putkey JA, Draetta GF, Slaughter GR, Klee CB, Cohen P, Stull JT and Means AR. (1986). Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem 261:9896-9903.
  10. Slaughter GR and Means AR. (1983). FSH activation of glycogen phosphorylase in the Sertoli cell enriched rat testis. Endocrinology 113:1476-1485.

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