About the Laboratory
Established in August 1997, the Zechiedrich laboratory is located in the largest medical center in the world. We take a systems approach to antibiotic resistance, work initially funded by a New Investigator award from the Burroughs Wellcome Fund, a genome sequencing award from Applied Biosystems, and the NIH since 2004.
Our laboratory also works to understand the DNA topoisomerases, which are targets of fluoroquinolone antibiotics in bacteria and anti-cancer drugs in humans.
Because the essential topoisomerases modulate DNA, the work in our laboratory has broadened to include creating tiny circles of DNA to study DNA supercoiling and how it affects topoisomerases and how drugs inhibit topoisomerases. These tiny circles of DNA have become a new gene therapy delivery tool. This work was first funded by the National Science Foundation, an award from the John S. Dunn Foundation, a collaborative grant from the Human Frontier Science Program, seed funding from the Northwest Genome Engineering Consortium in Seattle, seed funding from the Baylor–UT Houston Center for AIDS Research, an Alkek Center for Metagenomics and Microbiome research pilot award, and is currently funded by the NIH.
The multidisciplinary research in the laboratory provides ample opportunity for training. Dr. Zechiedrich has trained nine previous and one current postdoctoral fellows, 12 former and four current graduate students, three former and one current post-baccalaureate students, 21 former undergraduate students, and three high school students in addition to hosting three visiting professors. She has published and lectured nationally on mentoring and was Baylor College of Medicine’s BRASS Mentor of the Year in 2013. Former trainees from the Zechiedrich laboratory continue to contribute to science in multiple different capacities. They are college professors, company scientists and CEO's, medical doctors, science writers, postdoctoral fellows, and leaders in K12 education.