About the Lab
Research in the Hodges lab focuses on altered epigenetic function in cancer and other diseases. We use interdisciplinary approaches, including epigenomics, live-cell super-resolution imaging, genome editing, and chemical biology, to understand epigenetic systems in disease settings. Our research is especially focused on new technologies, for example, improving cell-culture tumor models, as well as single-cell and single-molecule methods, to understand how altered transcriptional programs contribute to disease, with the goal to identify new opportunities for therapy.
Disruption of chromatin regulatory systems is a widespread feature of many diseases, including cancer. One of the major chromatin regulators with frequent contributions to malignancy is the family of BAF (SWI/SNF) and PBAF complexes. These ATP-dependent chromatin remodelers harness the free energy of ATP hydrolysis to power mechanical changes of the chromatin landscape. Such changes include moving and ejecting histones from DNA, an essential activity for regulating DNA accessibility for transcription factors, topoisomerases, and state changes within the nucleus.
Dr. Hodges is a CPRIT Scholar has as received several awards, including the AACR NextGen Star Award, the Medical Research Award from the Gabrielle’s Angel Foundation, and the V Scholar Award from the V Foundation for Cancer Research. Dr. Hodges is also the recipient of the NIH Pathway to Independence Award from the National Cancer Institute.