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Yong Xu Lab

Publications

Master
Content

2020

Liu H, Xu Y, Hu F. AMPK in the Ventromedial Nucleus of the Hypothalamus: a Key Regulator for Thermogenesis. Frontier Endocrinology 2020 September 23; (11).

Yu K, He Y, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Gourdy P, Arnal JF, Lenfant F, Xu Y and Wang C. 17β-estradiol promotes acute refeeding in hungry mice by membrane-initiated ERα signaling. Molecular Metabolism 2020 July 23; (42) 101053. PMID: 32712433. doi: 10.1016/j.molmet.2020.101053.

Kim ER,  Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Drunen RV, Ribas-Latre A, Cai ZL, Xuee M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q. Paraventricular hypothalamus mediates diurnal rhythm of metabolism.  Nature Communications 2020 July 30;11:3794. PMID: 32732906. PMCID: PMC7393104. doi: 10.1038/s41467-020-17578-7.

Sun Z and Xu Y. Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain. Endocrinology 2020 Aug 1;161(8):bqaa083. doi: 10.1210/endocr/bqaa083. PMID: 32449767. PMCID: PMC7351129.

Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel RB, Wu Q, Shu G and Tong Q. Profound and Redundant Functions of Arcuate Neurons in Obesity Development. Nature Metabolism 2020 August; 2(8):763-774. doi: 10.1038/s42255-020-0229-2. PMID: 32719538.

He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nature Communications 2020 May 1;11(1):2165. doi: 10.1038/s41467-020-15982-7.

Zhu C, Xu Y, Jiang Z, Tian JB, Cassidy RM, Cai Z, Shu G, Xu Y, Xue M, Arenkiel BR, Jiang Q and Tong Q. Disrupted hypothalamic CRH neuron responsiveness contributes to diet-induced obesity. EMBO Reports 2020 Jul 3;21(7):e49210. doi: 10.15252/embr.201949210. Epub 2020 May 27.

Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley S. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. Journal of Steroid Biochemistry and Molecular Biology 2020 Jun; 200:105690. doi: 10.1016/j.jsbmb.2020.105690. Epub 2020 May 11.

Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, and Nuotio-Antar AM. Metabolic dysregulation in the Atp7b−/− Wilson’s disease mouse model. PNAS first published January 10, 2020 https://doi.org/10.1073/pnas.1914267117.

2019

Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y.  A POMC-originated circuit regulates stress-induced hypophagia, depression and anhedonia. Molecular Psychiatry 2019 Sep 5. doi: 10.1038/s41380-019-0506-1. [Epub ahead of print]. PMID: 31485012.

Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. The Journal of Clinical Investigation 2019 Aug 12;130:3786-3791. doi: 10.1172/JCI126107. PMID: 31403469.

Xu Y, Lu Y, Cassidy R, Mangieri L, Zhu C, Huang X, Jiang Z, Justice N, Xu Y, Arenkiel B, and Tong Q. Identification of a neurociruit underlying regulation of feeding by stress-related emotional responses.  Nature Communications 2019 Aug 1;10(1):3446. doi: 10.1038/s41467-019-11399-z. PMID: 31371721; PMCID: PMC6671997.

Mangieri L, Jiang Z, Lu Y, Xu Y, Cassidy R, Justice N, Xu Y, Arenkiel B, Tong Q. Defensive behaviors driven by a hypothalamic-ventral midbrain circuit. eNeuro 2019 Jul 29;6(4). pii: ENEURO.0156-19.2019. doi: 10.1523/ENEURO.0156-19.2019. Print 2019 Jul/Aug. PMID: 31331938; PMCID: PMC6664144.

Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler L, Wang C, Xu P, Saito K, Hinton Jr. A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O’Rahilly S, Tong Q, UK10K consortium, Barroso I, O’Malley BW, Farooqi IS, Xu Y. Steroid Receptor Coactivator-1 Modulates the Function of Pomc Neurons and Energy Homeostasis. Nature Communications, 2019 Apr 12;10(1):1718. doi: 10.1038/s41467-019-08737-6. PMID: 30979869. PMCID: PMC6461669.  

Cassidy RM, Lu Y, Jere M, Tian JB, Xu Y, Mangieri LR, Felix-Okoroji B, Selever J, Xu Y, Arenkiel BR, Tong Q. A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues. Science Advances. 2019 Mar 6;5(3):eaav1640. doi: 10.1126/sciadv.aav1640. eCollection 2019 Mar. PMID: 30854429. PMCID: PMC6402846.

Wang C and Xu Y. Mechanisms for sex differences in energy homeostasis. Journal of Molecular Endocrinology 2019 Feb;62(2):R129-R143. doi: 10.1530/JME-18-0165. PMID: 31130779. PMCID: PMC6528488.

Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, Han G, Newell-Fugate A, Tian Y, Majeti R, Liu W, Xu Y, Wu C, Allred K, Allred C, Sun Y and Guo S. Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1. Diabetes, 2019 Feb; 68(2):291-304. PMID: 30487265. PMCID: PMC6341301.

Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O’Driscoll M, Morton J, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y, and Zheng Sun. NCOR1/2 loss of function impairs memory through a novel GABAergic hypothalamus–CA3 projection. Nature Neuroscience 2019 Feb;22(2):205-217. doi: 10.1038/s41593-018-0311-1. Epub 2019 Jan 21 PMID: 30664766. PMCID: PMC6361549.

2018

Yu S, Cheng H, François M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud HR, Münzberg H; Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife 2018 May 15;7. pii: e33505. doi: 10.7554/eLife.33505. PMID: 29761783. PMCID: PMC5953538.

Xu Y, Lopez M. Central regulation of energy metabolism by estrogens. Molecular Metabolism 2018 May 23. pii: S2212-8778(18)30257-6. doi: 10.1016/j.molmet.2018.05.012. [Epub ahead of print]. PMID: 29886181.

Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER and Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nature Communications 2018 Apr 18;9(1):1544. doi: 10.1038/s41467-018-03796-7. PMID: 29670083. PMCID: PMC5906443.

Zhang P, Kuang H, He Y, Idiga SO, Li S, Chen Z, Yang Z, Cai X, Zhang K, Potthoff MJ, Xu Y, Lin J. NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight 2018 Mar 8;3(5). pii: 98522. doi: 10.1172/jci.insight.98522. [Epub ahead of print].

2017

Xu J, Zhu C, Zhang M, Tong Q, Wan X, Liao Z, Cai X, Xu Y, Yuan Y, Wang L, Zhu X, Wang S, Gao P, Xi Q, Xu Y, Jiang Q, Shu G; Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway. Metabolism 2018 Feb;79:10-23. doi: 10.1016/j.metabol.2017.10.006. PMID: 29080813.

Mangieri L, Lu Y, Xu Y, Cassidy R, Xu Y, Arenkiel B, and Tong Q. A Neural Basis for Antagonistic Control of Feeding and Compulsive Behaviors. Nature Communications 2018 Jan 4;9(1):52. doi: 10.1038/s41467-017-02534-9.

Bai J, Cervantes, C, Liu J, He S, Zhou H, Zhang B, Cai H, Yin D, Hu D, Li Z, Chen H, Gao X, Wang F, O’Connor JC, Xu Y, Liu M, Dong LQ, Liu F. DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing mtDNA release-activated cGAS-cGAMP-STING pathway. Proc Natl Acad Sci USA 2017 Nov 14;114(46):12196-12201. doi: 10.1073/pnas.1708744114. PMID: 29087318.

Duerreschmid C, He Y, Wang C, Li C, Bournat J, Romere C, Saha PK, Phillps KJ, Jain P, Farias M, Wu Q, Milewicz DM, Suton VR, Moore DD, Butte NF, Krashes MJ, Xu Y, Chopra AR. Asprosin is a centrally-acting orexigenic hormone. Nature Medicine 2017 Nov 6. doi: 10.1038/nm.4432. PMID: 29106398.

Zhu C, Xu P, He Y, Yuan Y, Wang T, Cai X, Yu L, Yang L, Wu J, Wang L, Zhu X, Wang S, Gao P, Xi Q, Zhang Y, Xu Y, Jiang Q, Shu G. Heparin increases food intake through AgRP neurons. Cell Reports 2017 Sep 5;20(10):2455-2467. doi: 10.1016/j.celrep.2017.08.049. PMID: 28877477.

 Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. 2017 May 26;4(3). pii: ENEURO.0083-17.2017. doi: 10.1523/ENEURO.0083-17.2017. eCollection 2017 May-Jun. PMID: 285603156.

Wu CS, Bongmba O, Yue J, Lee YH, Lin L, Saito K, Pradhan G, Li DP, Pan HK, Xu A, Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis. The International Journal of Mechanical Sciences 2017 Apr 14;18(4). pii: E832. doi: 10.3390/ijms18040832. PMID: 28420089. PMCID: PMC5412416.

Xu Y, O’Malley BW, Elmquist JK. Brain nuclear receptors and body weight regulation. The Journal of Clinical Investigation 2017 Apr 3;127(4):1172-1180. doi: 10.1172/JCI88891. Epub 2017 Feb 20. PMID: 28218618.

Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Xia Y, Hyseni Ilirjana, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism 2017 May; 70: 152-159.

2016

Hinton A, Yang Y, Qick AP, Xu P, Reddy Chitra, Xia Y, Reynolds Corey, Tong Q, Zhu L, Xu J, Wehrens Xander, Xu Y, Reddy Anihumar. SRC-1 regulates blood pressure and aortic stiffness in female mice. Plos One 2016 Dec 22;11(12):e0168644. doi: 10.1371/journal.pone.0168644. eCollection 2016.

He Y, Shu G, Xu P, Yang Y, Xia Y, Wang C, Saito K, Hinton A, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A small potassium current in AgRP/NPY neurons regulates feeding behavior and energy metabolism. Cell Reports 2016 November 8; 17: 1807-1818.

Kaneko K, Xu P, Ng A, Xu Y, Elmquist JK, Morozov A, Fukuda M. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions. Cell Reports 2016 Sep 13;16(11):3003-15. doi: 10.1016/j.celrep.2016.08.039. PMID: 27626668. PMCID: PMC5024738.

Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton Jr. A, Zhu L, Shu G, Myers Jr. MG, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice. Biological Psychiatry (highlighted as Priority Communication). 2016 Jun 9. pii: S0006-3223(16)32470-2. doi: 10.1016/j.biopsych.2016.06.005. PMID: 27516377.

Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Chen S, Gardner D, Seeley RJ, Sandoval DA. Hypothalamic vitamin D improves glucose homeostasis and improves weight. Diabetes 2016 May 23  pii: db160309. PMID: 27217488.

Hu F, Xu Y, Liu F. Hypothalamic Roles of mTOR Complex I: Integration of nutrient and hormone signals to regulate energy homeostasis. AJP-Endocrinology and Metabolism 2016 Jun 1;310(11):E994-E1002. doi: 10.1152/ajpendo.00121.2016. PMID: 27166282. PMCID: PMC4935144.

Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba O, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity. Diabetes 2016 Aug;65(8):2169-78. doi: 10.2337/db15-1587. PMID: 27207529. PMCID: PMC4955988.

Hinton A, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in the medial amygdala prevents stress-induced elevations in blood pressure in females. Hypertension 2016 Apr 18. Epub 2016 Apr 18. doi: 10.1161/HYPERTENSIONAHA.116.07175. PMID: 27091896. PMCID: PMC4865414.

Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton A, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on 2 energy expenditure in female mice. Scientific Reports-Nature 2016 March 18:6: 23459. doi: 10.1038/srep23459 PMID: 26988598; PMCID: PMC4796901.

Meng F, Han Y, Srisai D, Belakhov V, Farias M, Xu Y, Palmiter RD, Baasov T, Wu Q. A new inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A 2016 Mar 29; 113(13)3645-50. pii: 201602049. PMID: 26976589.

Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton Jr. A,  Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line. Metabolism 2016 Apr;65(4):522-32. doi: 10.1016/j.metabol.2015.12.011. Epub 2015 Dec 29. PMID:26975544.

Xu Y, Chang JT, Myers Jr. MG, Xu Y, Tong Q. Euglycemia restoration by central leptin in Type 1 diabetes requires STAT3 signaling but not fast-acting neurotransmitter release. Diabetes 2016 Jan 28. pii: db151160. [Epub ahead of print]. PMID: 26822087.

Fan S, Dakshinamoorthy J, Kim ER, Xu Y, Huang C, and Tong Q. An indirect action contributes to c-fos induction in paraventricular hypothalamic nucleus by neuropeptide Y. Scientific Reports-Nature 2016 Jan 27;6:19980. doi: 10.1038/srep19980. PMID 26813148. PMCID: PMC4728490.  

2015

Zhu L, Xu P, Cao X, Yang Y, Hinton A, Xia Y, Saito K, Yan X, Zou F, Ding F, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERα-PI3K cascade in pro-opiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice. Endocrinology 2015 Dec; 156(12)4474-91. PMID: 26375425.

Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton A, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV inhibits AgRP/NPY neurons and activates POMC neurons in the arcuate nucleus. Neuroendocrinology 2015 August 25. [Epub ahead of print] PMID: 26337236.

Xu P, Cao X, Xu Y. Physical activity controlled by estrogen signals in the medial amygdala. Receptors & Clinical Investigation 2015; 2: e975. dio:10.14800/rci.975.

Xu P, Cao X, Xu Y. Targeting brain estrogen receptor for binge eating. Oncotarget 2015 August 22. [Epub ahead of print] PMID: 26309082.

Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton A, Zou F, Ding H, Xia Y, Yan C, Wu SP, Yang B, Feng Y, Clegg DJ, DiMarchi R, Khan SA, Tsai SY, DeMayo FJ, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in medial amygdala neurons regulates body weight. The Journal of Clinical Investigation 2015 Jul 1;125(7):2861-76. PMID: 26098212.

Saito K, Cao X, He Y, Xu Y. Progress in the molecular understanding of central regulation of body weight by estrogens. Obesity. 2015 May;23(5):919-26. PMID: 25865677. PMCID: PMC4414873. 

Zhu L, Zou F, Yang Y, Xu P, Saito K, Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042.

Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton A, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-Chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. British Journal of Pharmacology. 2015 Mar 27. doi: 10.1111/bph.13141. PMID: 25817043 [Epub ahead of print].

Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. The Journal of Neuroscience. 2015 Feb 25; 35(8):3312-8. PMID: 25716832.

2014

Shu G, Lu N, Zhu X, Xu Y, Du M, Xie Q, Zhu C, Xu Q, Wang S, Wang L, Gao P, Xi Q, Zhang Y, Jiang Q. Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo. The Journal of Nutritional Biochemistry 2014 Dec;25(12):1296-308. PMID:25283330.

Scott MM, Xu Y, Elias CF and Williams KW. Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis. Frontiers in Neuroscience 2014 Dec 3;8:384. PMID:25520610. PMCID:PMC4253741. 

Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton Jr. A, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. The Journal of Clinical Investigation 2014 August 26; 124(10):4351-4362.

Xu Y, Kim ER, Fan S, Xia Y, Xu Y, Huang C, Tong Q. Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochemical and Biophysical Research Communications 2014 July 24 (Epub).

2013

Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams, KW, Xu Y, Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. The Journal of Clinical Investigation 2013 December 2; 123(12):5061-70. PMID: 24177424. PMCID: PMC3859401.

Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y and Tong Q. Glutamate mediates the function of melanocortin receptors 4 on Sim1 neurons in body weight regulation. Cell Metabolism 2013 December 3; 18(6):860-70. PMID: 24315371.

Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metabolism 2013 July 2; 18(1):86-89. PMID: 23823479. PMCID: PMC3752162.

Davis KE, Neinast MD, Sun K, Skiles WM, Dills JD, Zehr JA, Zeve D, Hahner LD, Cox DW, Gent LM, Xu Y, Wang ZV, Khan SA, Clegg DJ. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Molecular Metabolism 2013 Jun 4;2(3):227-42. PMID: 24049737. PMCID: PMC3773827.

Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Molecular Cellular Biology 2013 Jun;33(11):2327-38. PMCID: PMC3648066. PMCID: PMC3648066.

Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O’Malley BW, Xu Y. Steroid receptor co-activator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 2013 Jan;154(1):150-8. PMID: 23211707. PMCID: PMC3529365.

2012

Tong Q and Xu Y. Central Leptin Regulation of Obesity and Fertility. Current Obesity Reports 2012 Dec 1;1(4):236-244. PMCID: PMC3519445.

Xu Y, Faulkner LD and Hill JW. Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons. Frontiers in Systems and Translational Endocrinology 2012 Jan 4; 2: 1-13. PMCID: PMC3355979.

2011

Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK and Clegg DJ. Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction. Cell Metabolism 2011 Oct 5;14(4):453-465. PMID: 21982706. PMCID: PMC3235745.

Xu Y, Elmquist JK and Fukuda M. Central nervous control of energy and glucose balance: focus on central melanocortin system. Annals of the New York Academy of Sciences 2011 Dec;1243(1):1-14. PMID: 22211889. PMCID: PMC3467098.

Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate nucleus pro-opiomelanocortin neurons via TRPC channels. Neuron 2011 Aug 11;71(3):488-97. PMID: 21835345. PMCID: PMC3184528.

Kim KW, Zhao L, Donata J , Khono D, Xu Y, Lee C, Parker K, Elmquist JK. Steroidogenic Factor 1 Directs Programs Regulating Diet-Induced Thermogenesis and Leptin Action in the Ventral Medial Hypothalamic Nucleus. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10673-8. PMID: 21636788. PMCID: PMC3127910.

Marino JS, Xu Y, Hill JW. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab. 2011 July;22(7):275-85. PMID: 21489811. PMC Journal - In Process.

Kim KW, Sohn JW, Kohno D, Xu Y, Williams K, Elmquist JK. SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):219-23. PMID: 2111025. PMCID: PMC3057357.

2010

Xu Y, Berglund DE, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE and Elmquist JE. 5-HT2CRs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver. Nature Neuroscience. 2010 Dec; 1(12):1457-9. PMID: 21037584. PMCID: PMC3059249.

Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB and Elmquist JK. A Serotonin and Melanocortin Circuit Mediates d-Fenfluramine Anorexia. The Journal of Neuroscience. 2010 Nov 3;30(44):14630-4. PMID: 21048120. PMCID: PMC3466475.

Xu Y, Hill JW, Gautron L, Lee CE, Choi MJ, Dhillon H, Lowell BB, Zigman JM, Zhao JJ and Elmquist JK. PI3K signalling in ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metabolism. 2010 Jul 4;12(1):88-95. PMID: 20620998. PMCID: PMC2919367.

Hill JW, Elias CF, Fukuda M, Cho YR, Chuang JC, Xu Y, Choi MJ, Balthasar N, Coppari R, Scherer PE, Brüning JC, Lowell BB, Elmquist JK. Direct insulin and leptin action in pro-opiomelanocortin neurons is required for normal glucose homeostasis and fertility. Cell Metabolism. 2010 Apr 7;11(4):286-97. PMID: 20374961. PMCID: PMC2854520.

2009

Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo L, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. PI3K signaling in hypothalamic POMC neurons contributes to the regulation of glucose homeostasis. Endocrinology. 2009 Nov;150(11):4874-82. PMID: 19819947. PMCID: PMC2775989.

2008

Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB and Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 2008 Nov;60(4):582-589. PMID: 19038216. PMCID: PMC2631191.