Yong Xu Lab

Xu Lab Publications


Cai J, Xu Y, Jiang Z, Jiang Y, Li H, Otiz-Guzman J, Xu Y, Arenkiel BR and Tong Q. An excitatory projection from the basal forebrain to the ventral tegmental area underlying anorexia-like phenotypes. Neuron 2023 Dec 1: S0896-6273(23)00845-0. Dio: 10.1016/j.neuron.2023.11.001. PMID: 38056455.

Tong L, Xu Y. Chronic stress adds fuel to gut flame. Obesity Medicine 2023 Dec, 100519. doi:10.1016/j.obmed.2023.100519.

Tu L, He Y, Xu Y. Anoctamin 4 defines glucose-inhibited neurons in the ventromedial hypothalamus. Neural Regeneration Research 2023; 19(6):p1177-1178.  doi:10.4103/1673-5374.385867.

Xue Y, Gong Y, Li X, Peng F, Ding G, Zhang Z, Shi J, Savul IS, Xu Y, Chen Q, Han L, Mao S, Sun Z. Sex differences in paternal arsenic-induced intergenerational metabolic effects are mediated by estrogen. Cell & Bioscience 2023 Sep 10;13(1):165. doi: 10.1186/s13578-023-01121-4. PMID: 37691128. PMCID: PMC10493026.

Conde K, Fang S, Xu Y. Unraveling the serotonin saga: from discovery to weight regulation and beyond - a comprehensive scientific review. Cell & Bioscience 2023; 13:143. doi:10.1186/s13578-023-01091-7.

Liu H, Li H, Xu Y. Hunger extends lifespan by modulating histone proteins. Life Metabolism 2023 doi: 10.1093/lifemeta/load024.

Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarlet NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. Journal of Clinical Investigation 2023 Jun 1;e163391. doi: 10.1172/JCI163391. Online ahead of print.

Xu Y, Jiang Z, Li H, Cai J, Jiang Y, Otiz-Guzman J, Xu Y, Arenkiel BR, Tong Q. Lateral septum as a melanocortin downstream site in obesity development. Cell Reports. 2023 Jun 6;42(6):112626. dio: 10.1016/j.celrep.2023.112626.

Li H, Xu Y, Jiang Y, Jiang Z, Otiz-Guzman J, Morrill JC, Cai J, Mao Z, Xu Y, Arenkiel BR, Huang C, Tong Q. The melanocortin action is biased toward protection from weight loss in mice. Nature Communications (2023) April 17;14(1):2200. dio:10.1038/s41467-023-37912-z. PMID: 37069175. PMCID: PMC10110624. 

Han Y, He Y, Harris L, Xu Y, Wu Q. Identification of a GABAergic neural circuit governing leptin signalling deficiency – induced obesity. Elife (2023) April 12;12:e82649. (1):2200. dio: 10.7554/eLife.82649. PMID: 37043384. PMCID: PMC10097419.

Wang M, Yang Y, Xu Y. Brain nuclear receptors and cardiovascular function. Cell & Bioscience (2023) 13:14. doi:10.1186/s13578-023-00962-3.

Liu H, He Y, Bai J, Zhang C, Zhang F, Yang Y, Luo H, Yu M, Liu H, Tu L, Zhang N, Yin N, Han J, Yan Z, Scarcelli NA, Conde KM, Wang M, Bean JC, Potts C, Wang C, Hu F, Liu F and Xu Y. Hypothalamic Grb10 Enhances Leptin Signaling and Promotes Weight Loss. Nature Metabolism 2023 Jan 2. doi:10.1038/s42255-022-00701-x. PMID: 36593271. 

He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli KA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y (co-corresponding), Farooqi SI. Human loss-of-function variants in the Serotonin 2C receptor associated with obesity and maladaptive behaviour. Nature Medicine 2022 Dec 19. doi: 10.1038/s41591-022-02106-5. PMID: 36536256.

Yu M, Bean JC, Liu H, He Y, Yang Y, Cai X, Yu K, Pei Z, Liu H, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Scarcelli NA, Xu P, He Y, Xu Y(co-corresponding) and Wang C. SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis. Cell Biosci 2022 October 9; 12(1): 170. doi:10.1186/s13578-022-00907-2. PMID: 36210455. PMCID: PMC9549684.

Pei Zou, He Y, Bean JC, Yang Y, Yu M, Yu K, Hyseni I, Cai X, Liu H, Na Q, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Potts C, Scarcelli NA, Yan Z, Xu P, Wu Q, He Y, Xu Y(co-corresponding) and Wang C. Gabra5 plays a sexually dimorphic role in POMC neuron activity and glucose balance. Front Endocrinol 2022 August 31;13:889122. doi:10.3389/fendo.2022.889122. PMID: 36120438. PMCID: PMC9471380.

Li VL, He Y, Contrepois K, Liu H, Kim JT, Wiggenhorn AL, Tanzo JT, Tung A, Lyu X, Zushin PH, Jansen RS, Michael B, Loh KY, Yang AC, Carl CS, Voldstedlund CT, Wei W, Terrell SM, Moeller BC, Arthur RM, Wallis GA, Wetering K, Stahl A, Kiens B, Richter EA, Banik SM, Snyder MP, Xu Y (co-corresponding), Long JZ. An exercise-inducible metabolite that suppresses food intake and obesity. Nature 2022 Jun 15. doi: 10.1038/s41586-022-04828-5. Online ahead of print. PMID: 35705806.

Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nature Neuroscience 2022 May;25(5):646-658. doi: 10.1038/s41593-022-01062-0. Epub 2022 May 2.

Tu L, Fukuda M, Tong Q, Xu Y. The ventromedial hypothalamic nucleus: watchdog of whole-body glucose homeostasis. Cell & Bioscience 2022; 12:71. https://doi.org/10.1186/s13578-022-00799-2.

Liu H, Cai X, He Y, Xu Y. Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia. JMCB May 2022; mjac035, https://doi.org/10.1093/jmcb/mjac035.

Mishra I, Xie WR, Bournat JC, He Y, Wang C, Silva ES, He Y, Liu H, Ku Z, Chen Y, Erokwu BO, Jia P, Zhao Z, An Z, Flask CA, Xu Y, Chopra AR. Protein Tyrosine Phosphatase Receptor δ Serves as the Orexigenic Asprosin Receptor. Cell Metabolism 2022 Apr 5;34(4):549-563.e8. doi: 10.1016/j.cmet.2022.02.012. PMID: 35298903. PMCID: PMC8986618.

Ye H, Feng B, Wang C, Saito K, Yang Y, Ibrahimi L, Schaul S, Patel N, Saenz L, Luo P, Lai P, Torres V, Kota M, Dixit D, Cai X, Qu N, Hyseni I, Yu K, Jiang Y, Tong Q, Sun Z, Arenkiel BR, He Y, Xu P, Xu Y. An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Science Advances 2022 Jan 21; (8);eabk0185. doi: 10.1126/sciadv.abk0185. PMID: 35044814. Pmcid: PMC8769556.

Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Reports 2021 Dec 7;37(10):110075. doi: 10.1016/j.celrep.2021.110075. PMID: 34879284.

Yoo ES, Li L, Jia L, Lord CC, Lee CE, Vianna CR, Berglund ED, Cunningham KA, Xu Y, Sohn JW, Liu C. Gαi/o-coupled Htr2c in the Paraventricular Nucleus of the Hypothalamus Antagonizes the Anorectic Effect of Serotonin Agents. Cell Reports. 2021 Nov 16;37(7):109997. doi: 10.1016/j.celrep.2021.109997. PMID: 34788630.

Yan Z, He Y, Cai X, Shu G, Xu Y. Eating for hunger or pleasure: a serotonin model. JMCB September 2021; https://doi.org/10.1093/jmcb/mjab055.

Zhu Y, Li N, Huang M, Bartels M, Dogne S, Zhao S, Chen X, Crewe C, Straub L, Vishvanath L, Zhang Z, Shao M, Yang, Y, Glinkiak CM, Gordilla R, Smith GI, Holland WL, Gupta RK, Dong B, Caron N, Xu Y, Akgul Y, Klein S, Scherer PE. Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. Nature Communications 2021 Aug 10; 12(1): 4829. Doi: 10.1038/S41467-021-25025-4.

Tu L, Zhang N, Conde KM, Bean JC, Wang C, Xu Y. Free-floating Immunostaining of Mouse Brains. JOVE 2021 Oct 7;(176). doi: 10.3791/62876.

Kaneko K, Lin HY, Fu Y, Saha PK, Puente-Gomez A, Xu Y, Ohinata K, Chen P, Morozov A, Fukuda M. Rap1 in the VMH regulates glucose homeostasis. JCI Insight. 2021 Jun 8;6(11):e142545. doi: 10.1172/jci.insight.142545.

Zhang N, Yan Z, Liu H, Yu M, He Y, Liu H, Liang C, Tu L, Wang L, Yin N, Han J, Scarcelli N, Yang Y, Wang C, Zeng T, Chen LL, Xu Y. Hypothalamic perineuronal nets are regulated by sex and dietary interventions. Frontiers in Physiology 28 July 2021 | https://doi.org/10.3389/fphys.2021.714104.

He Y, Cai X, Liu H, Conde KM, Xu P, Li Y, Wang C, Yu M, He Y, Liu H, Liang C, Yang T, Yang Y, Yu K, Wang J, Zheng R, Liu F, Sun Z, Heisler L, Wu Q, Tong Q, Zhu C, Shu G, Xu Y. 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding. Molecular Psychiatry 2021 Jul 21. doi: 10.1038/s41380-021-01220-z. Online ahead of print.

He Y, Liu H, Yin N, Yang Y, Wang C, Yu M, Liu H, Liang C, Wang J, Tu L, Zhang N, Wang L, He Y, Fukuda M, Wu Q, Sun Z, Tong Q, Xu Y. Barbadin potentiates long-term effects of lorcaserin on POMC neurons and weight loss. Journal of Neuroscience 2021 Jun 30;41(26):5734-5746. doi: 10.1523/JNEUROSCI.3210-20.2021. Epub 2021 May 24.

Han Y, Xia G, Srisai D, Meng F, He Y, Ran Y, He Y, Farias M, Hoang G, Tóth I, Dietrich M, Chen MH, Xu Y, and Wu Q. Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nature Communications 2021 Jun 10;12(1):3525. doi: 10.1038/s41467-021-23846-x.

Han Y, Xia G, He Y, He Y, Farias M, Xu Y, Wu Q. A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation. Science Advances. 2021 May 26;7(22):eabf8719. doi: 10.1126/sciadv.abf8719. Print 2021 May.

Mishra I, Duerrschmid C, Ku Z, He Y, Xie W, Silva ES, Hoffmann J, Xin W, Zhang N, Xu Y, An Z, Chopra AR. Asprosin Neutralizing Antibodies as a Treatment for Metabolic Syndrome. Elife 2021 Apr 27;10:e63784. doi: 10.7554/eLife.63784.

Ding Y, Liu Y, Lee DK, Tong Z, Yu X, Li Y, Xu Y, Lanz RB, O'Malley BW, Xu J. Cell Lineage Tracing Links Estrogen Receptor α Loss in Erbb2-Positive Breast Cancers to the Arising of a Highly Proliferative and Metastatic Breast Cancer Subtype. PNAS 2021 May 25;118(21):e2100673118. doi: 10.1073/pnas.2100673118.

Fan S, Xu Y, Lu Y, Jiang Z, Li H, Morrill J, Cai J, Wu Q, Xu Y, Xue M, Arenkiel B, Huang C and Tong Q. A Neural Basis for Brain Leptin Action on Reducing Type 1 Diabetic Hyperglycemia. Nature Communications 2021 May 11;12(1):2662. doi: 10.1038/s41467-021-22940-4.

Liu T, Xu Y, Yi CX, Tong Q, Cai D. The hypothalamus for whole-body physiology: from metabolism to aging. Protein Cell 2021 April. PMID: 33826123 DOI: 10.1007/s13238-021-00834-x.

Xia G, Han Y, Meng F, He Y, Srisai D, Farias M, Dang M, Palmiter RD, Xu Y and Wu Q. Reciprocal control of obesity and anxiety-depressive disorder via a GABA and serotonin neural circuit. Molecular Psychiatry 2021. https://doi.org/10.1038/s41380-021-01053-w. PMID: 33762728.

Ding G, Li X, Hou X, Zhou W, Gong Y, Liu F, He Y, Song J, Wang J, Basil P, Li W, Qian S, Saha P, Wang J, Cui C, Yang T, Zou K, Han Y, Amos CI, Xu Y, Chen L, Sun Z. Rev-erb in GABAergic Neurons Controls Diurnal Hepatic Insulin Sensitivity. Nature 2021. https://doi.org/10.1038/s41586-021-03358-w.

Wang Y, Yang Y, Wang M, Wang S, Jeong JM, Xu L, Wen Y, Emontzpohl C, Atkins CL, Duong K, Moreno NF, Yuan X, Hall DR, Dar W, Feng D, Gao B, Xu Y, Czigany Z, Colgan SP, Bynon JS, Akira S, Brown JM, Eltzschig HK, Jacobsen EA, Ju C. Eosinophils attenuate hepatic ischemia-reperfusion injury in mice through ST2-dependent IL-13 production. Science Translational MedicineFeb 2021: Vol. 13, Issue 579, eabb6576. DOI: 10.1126/scitranslmed.abb6576. PMID: 33536281.

Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun S, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Translational Psychiatry 2021 Jan 5;11(1):11. doi: 10.1038/s41398-020-01161. PMID: 33414382.

Liu H, Wang C, Yu M, Yang Y, He Y, Liu H, Liang C, Tu L, Zhang N, Wang L, Wang J, Liu F, Hu F, Xu Y. TPH2 in the dorsal Raphe nuclei regulates energy balance in a sex-dependent manner. Endocrinology 2021, Vol. 162, No. 1, 1–16 | doi:10.1210/endocr/bqaa183.

Liu H, He Y, Beck J, Teixeira S, Harrison K, Xu Y (co-corresponding), Sisley S. Defining VDR expression in the brain using a novel VDRCre mouse. The Journal of Comparative Neurology 2020 Dec 25. doi: 10.1002/cne.25100. PMID: 33368246.

Zhang Z, Reis F, He Y, Park JW, DiVittorio JR, Sivakumar N, van Veen JE, Pereira S, Shum M, Anderson S, Nichols I, Paul K, Liesa M, Ajijola OA, Xu Y, Adhikari A, Correa SM. Estrogen-sensitive medial preoptic area neurons coordinate hypothermia and hypometabolism in mice. Nature Communications 2020, 11:6378 | https://doi.org/10.1038/s41467-020-20050-1.

Yang Y, Xu Y. The central melanocortin system and human obesity. Journal of Molecular and Cell Biology 2020 Sep 25;mjaa048. doi: 10.1093/jmcb/mjaa048. Online ahead of print. PMID: 32976556.

Liu H, Xu Y, Hu F. AMPK in the Ventromedial Nucleus of the Hypothalamus: a Key Regulator for Thermogenesis. Frontiers in Endocrinology 2020 September 23; (11).

Yu K, He Y, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Gourdy P, Arnal JF, Lenfant F, Xu Y (co-corresponding) and Wang C. 17β-estradiol promotes acute refeeding in hungry mice by membrane-initiated ERα signaling. Molecular Metabolism 2020 July 23; (42) 101053. PMID: 32712433. doi: 10.1016/j.molmet.2020.101053.

Kim ER, Xu Y, Cassidy RM, Lu Y, Yang Y, Tian J, Li DP, Drunen RV, Ribas-Latre A, Cai ZL, Xue M, Arenkiel BR, Eckel-Mahan K, Xu Y, Tong Q. Paraventricular hypothalamus mediates diurnal rhythm of metabolism. Nature Communications 2020 July 30;11:3794. PMID: 32732906. PMCID: PMC7393104. doi: 10.1038/s41467-020-17578-7.

Sun Z and Xu Y. Nuclear Receptor Coactivators (NCOAs) and Corepressors (NCORs) in the Brain. Endocrinology 2020 Aug 1;161(8):bqaa083. doi: 10.1210/endocr/bqaa083. PMID: 32449767. PMCID: PMC7351129.

Zhu C, Jiang Z, Xu Y, Cai ZL, Jiang Q, Xu Y, Xue M, Arenkiel RB, Wu Q, Shu G and Tong Q. Profound and Redundant Functions of Arcuate Neurons in Obesity Development. Nature Metabolism 2020 August; 2(8):763-774. doi: 10.1038/s42255-020-0229-2. PMID: 32719538.

He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance. Nature Communications 2020 May 1;11(1):2165. doi: 10.1038/s41467-020-15982-7. PMID: 32358493.

Zhu C, Xu Y, Jiang Z, Tian JB, Cassidy RM, Cai Z, Shu G, Xu Y, Xue M, Arenkiel BR, Jiang Q and Tong Q. Disrupted hypothalamic CRH neuron responsiveness contributes to diet-induced obesity. EMBO Reports 2020 Jul 3;21(7):e49210. doi: 10.15252/embr.201949210. Epub 2020 May 27.

Teixeira S, Harrison K, Uzodike M, Rajapakshe K, Coarfa C, He Y, Xu Y, Sisley S. Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects. Journal of Steroid Biochemistry and Molecular Biology 2020 Jun; 200:105690. doi: 10.1016/j.jsbmb.2020.105690. Epub 2020 May 11.

Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, and Nuotio-Antar AM. Metabolic dysregulation in the Atp7b−/− Wilson's disease mouse model. PNAS first published January 10, 2020 https://doi.org/10.1073/pnas.1914267117.

Hua X, Wang YY, Jia P, Xiong Q, Hu Y, Chang Y, Lai S, Xu Y, Zhao Z, Song J. Multi-level transcriptome sequencing identifies COL1A1 as a candidate marker in human heart failure progression. BMC Med. 2020 Jan 6;18(1):2. doi: 10.1186/s12916-019-1469-4.

Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y. A POMC-originated circuit regulates stress-induced hypophagia, depression and anhedonia. Molecular Psychiatry 2019 Sep 5. doi: 10.1038/s41380-019-0506-1. [Epub ahead of print]. PMID: 31485012.

Kaneko K, Fu Y, Lin HY, Cordonier EL, Mo Q, Gao Y, Yao T, Naylor J, Howard V, Saito K, Xu P, Chen SS, Chen MH, Xu Y, Williams KW, Ravn P, Fukuda M. Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition. The Journal of Clinical Investigation 2019 Aug 12;130:3786-3791. doi: 10.1172/JCI126107. PMID: 31403469.

Xu Y, Lu Y, Cassidy R, Mangieri L, Zhu C, Huang X, Jiang Z, Justice N, Xu Y, Arenkiel B, and Tong Q. Identification of a neurociruit underlying regulation of feeding by stress-related emotional responses. Nature Communications 2019 Aug 1;10(1):3446. doi: 10.1038/s41467-019-11399-z. PMID: 31371721; PMCID: PMC6671997.

Mangieri L, Jiang Z, Lu Y, Xu Y, Cassidy R, Justice N, Xu Y, Arenkiel B, Tong Q. Defensive behaviors driven by a hypothalamic-ventral midbrain circuit. eNeuro 2019 Jul 29;6(4). pii: ENEURO.0156-19.2019. doi: 10.1523/ENEURO.0156-19.2019. Print 2019 Jul/Aug. PMID: 31331938; PMCID: PMC6664144.

Zhang W, Wu X, Pei Z, Kiess W, Yang Y, Xu Y, Chang Z, Wu J, Sun C, Luo F. GDF5 Promotes White Adipose Tissue Thermogenesis via p38 MAPK Signaling Pathway. DNA and Cell Biology 2019 Nov;38(11):1303-1312. doi: 10.1089/dna.2019.4724. Epub 2019 Sep 25.

Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler L, Wang C, Xu P, Saito K, Hinton Jr. A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, UK10K consortium, Barroso I, O'Malley BW, Farooqi IS, Xu Y. Steroid Receptor Coactivator-1 Modulates the Function of Pomc Neurons and Energy Homeostasis. Nature Communications, 2019 Apr 12;10(1):1718. doi: 10.1038/s41467-019-08737-6. PMID: 30979869. PMCID: PMC6461669.

Cassidy RM, Lu Y, Jere M, Tian JB, Xu Y, Mangieri LR, Felix-Okoroji B, Selever J, Xu Y, Arenkiel BR, Tong Q. A lateral hypothalamus to basal forebrain neurocircuit promotes feeding by suppressing responses to anxiogenic environmental cues. Science Advances. 2019 Mar 6;5(3):eaav1640. doi: 10.1126/sciadv.aav1640. eCollection 2019 Mar. PMID: 30854429. PMCID: PMC6402846.

Wang C and Xu Y. Mechanisms for sex differences in energy homeostasis. Journal of Molecular Endocrinology 2019 Feb;62(2):R129-R143. doi: 10.1530/JME-18-0165. PMID: 31130779. PMCID: PMC6528488.

Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, Han G, Newell-Fugate A, Tian Y, Majeti R, Liu W, Xu Y, Wu C, Allred K, Allred C, Sun Y and Guo S. Estrogen improves insulin sensitivity and suppresses gluconeogenesis via the transcription factor Foxo1. Diabetes, 2019 Feb; 68(2):291-304. PMID: 30487265. PMCID: PMC6341301.

Zhou W, He Y, Rehman AU, Kong Y, Hong S, Ding G, Yalamanchili HK, Wan YW, Paul B, Wang C, Gong Y, Zhou W, Liu H, Dean J, Scalais E, O'Driscoll M, Morton J, Hou X, Wu Q, Tong Q, Liu Z, Liu P, Xu Y (co-corresponding author), and Sun Z. NCOR1/2 loss of function impairs memory through a novel GABAergic hypothalamus–CA3 projection. Nature Neuroscience 2019 Feb;22(2):205-217. doi: 10.1038/s41593-018-0311-1. Epub 2019 Jan 21 PMID: 30664766. PMCID: PMC6361549.

Yu S, Cheng H, François M, Qualls-Creekmore E, Huesing C, He Y, Jiang Y, Gao H, Xu Y, Zsombok A, Derbenev AV, Nillni EA, Burk DH, Morrison CD, Berthoud HR, Münzberg H; Preoptic leptin signaling modulates energy balance independent of body temperature regulation. Elife 2018 May 15;7. pii: e33505. doi: 10.7554/eLife.33505. PMID: 29761783. PMCID: PMC5953538.

Xu Y, Lopez M. Central regulation of energy metabolism by estrogens. Molecular Metabolism 2018 May 23. pii: S2212-8778(18)30257-6. doi: 10.1016/j.molmet.2018.05.012. [Epub ahead of print]. PMID: 29886181.

Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER and Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nature Communications 2018 Apr 18;9(1):1544. doi: 10.1038/s41467-018-03796-7. PMID: 29670083. PMCID: PMC5906443.

Zhang P, Kuang H, He Y, Idiga SO, Li S, Chen Z, Yang Z, Cai X, Zhang K, Potthoff MJ, Xu Y, Lin J. NRG1-Fc improves metabolic health via dual hepatic and central action. JCI Insight 2018 Mar 8;3(5). pii: 98522. doi: 10.1172/jci.insight.98522. [Epub ahead of print].

Xu J, Zhu C, Zhang M, Tong Q, Wan X, Liao Z, Cai X, Xu Y, Yuan Y, Wang L, Zhu X, Wang S, Gao P, Xi Q, Xu Y, Jiang Q, Shu G; Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway. Metabolism 2018 Feb;79:10-23. doi: 10.1016/j.metabol.2017.10.006. PMID: 29080813.

Mangieri L, Lu Y, Xu Y, Cassidy R, Xu Y, Arenkiel B, and Tong Q. A Neural Basis for Antagonistic Control of Feeding and Compulsive Behaviors. Nature Communications 2018 Jan 4;9(1):52. doi: 10.1038/s41467-017-02534-9.

Bai J, Cervantes, C, Liu J, He S, Zhou H, Zhang B, Cai H, Yin D, Hu D, Li Z, Chen H, Gao X, Wang F, O'Connor JC, Xu Y, Liu M, Dong LQ, Liu F. DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing mtDNA release-activated cGAS-cGAMP-STING pathway. Proc Natl Acad Sci USA 2017 Nov 14;114(46):12196-12201. doi: 10.1073/pnas.1708744114. PMID: 29087318.

Duerreschmid C, He Y, Wang C, Li C, Bournat J, Romere C, Saha PK, Phillps KJ, Jain P, Jia P, Zhao Z, Farias M, Wu Q, Milewicz DM, Suton VR, Moore DD, Butte NF, Krashes MJ, Xu Y (corresponding author), Chopra AR. Asprosin is a centrally-acting orexigenic hormone. Nature Medicine 2017 Nov 6. doi: 10.1038/nm.4432. PMID: 29106398.

Zhu C, Xu P, He Y, Yuan Y, Wang T, Cai X, Yu L, Yang L, Wu J, Wang L, Zhu X, Wang S, Gao P, Xi Q, Zhang Y, Xu Y (corresponding author), Jiang Q, Shu G. Heparin increases food intake through AgRP neurons. Cell Reports 2017 Sep 5;20(10):2455-2467. doi: 10.1016/j.celrep.2017.08.049. PMID: 28877477.

Xu Y, Lu Y, Xu P, Mangieri LR, Isingrini E, Xu Y, Giros B, Tong Q. VMAT2-Mediated Neurotransmission from Midbrain Leptin Receptor Neurons in Feeding Regulation. eNeuro. 2017 May 26;4(3). pii: ENEURO.0083-17.2017. doi: 10.1523/ENEURO.0083-17.2017. eCollection 2017 May-Jun. PMID: 285603156.

Wu CS, Bongmba O, Yue J, Lee YH, Lin L, Saito K, Pradhan G, Li DP, Pan HK, Xu A,
Guo S, Xu Y, Sun Y. Suppression of GHS-R in AgRP neurons mitigates diet-induced obesity by activating thermogenesis. The International Journal of Mechanical Sciences 2017 Apr 14;18(4). pii: E832. doi: 10.3390/ijms18040832. PMID: 28420089. PMCID: PMC5412416.

Xu Y (corresponding author), O'Malley BW, Elmquist JK. Brain nuclear receptors and body weight regulation. The Journal of Clinical Investigation 2017 Apr 3;127(4):1172-1180. doi: 10.1172/JCI88891. Epub 2017 Feb 20. PMID: 28218618.

Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Xia Y, Hyseni Ilirjana, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism 2017 May; 70: 152-159.

Hinton A, Yang Y, Qick AP, Xu P, Reddy Chitra, Xia Y, Reynolds Corey, Tong Q, Zhu L, Xu J, Wehrens Xander, Xu Y (corresponding author), Reddy Anihumar. SRC-1 regulates blood pressure and aortic stiffness in female mice. Plos One 2016 Dec 22;11(12):e0168644. doi: 10.1371/journal.pone.0168644. eCollection 2016.

He Y, Shu G, Xu P, Yang Y, Xia Y, Wang C, Saito K, Hinton A, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A small potassium current in AgRP/NPY neurons regulates feeding behavior and energy metabolism. Cell Reports 2016 November 8; 17: 1807-1818.

Kaneko K, Xu P, Ng A, Xu Y, Elmquist JK, Morozov A, Fukuda M. Neuronal Rap1 regulates energy balance, glucose homeostasis, and leptin actions. Cell Reports 2016 Sep 13;16(11):3003-15. doi: 10.1016/j.celrep.2016.08.039. PMID: 27626668. PMCID: PMC5024738.

Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton Jr. A, Zhu L, Shu G, Myers Jr. MG, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice. Biological Psychiatry (highlighted as Priority Communication). 2016 Jun 9. pii: S0006-3223(16)32470-2. doi: 10.1016/j.biopsych.2016.06.005. PMID: 27516377.

Sisley SR, Arble DM, Chambers AP, Gutierrez-Aguilar R, He Y, Xu Y, Chen S, Gardner D, Seeley RJ, Sandoval DA. Hypothalamic vitamin D improves glucose homeostasis and improves weight. Diabetes 2016 May 23. pii: db160309. PMID: 27217488.

Hu F, Xu Y, Liu F. Hypothalamic Roles of mTOR Complex I: Integration of nutrient and hormone signals to regulate energy homeostasis. AJP-Endocrinology and Metabolism 2016 Jun 1;310(11):E994-E1002. doi: 10.1152/ajpendo.00121.2016. PMID: 27166282. PMCID: PMC4935144.

Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba O, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal deletion of ghrelin receptor almost completely prevents diet-induced obesity. Diabetes 2016 Aug;65(8):2169-78. doi: 10.2337/db15-1587. PMID: 27207529. PMCID: PMC4955988.

Hinton A, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in the medial amygdala prevents stress-induced elevations in blood pressure in females. Hypertension 2016 Apr 18. Epub 2016 Apr 18. doi: 10.1161/HYPERTENSIONAHA.116.07175. PMID: 27091896. PMCID: PMC4865414.

Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton A, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on 2 energy expenditure in female mice. Scientific Reports-Nature 2016 March 18:6: 23459. doi: 10.1038/srep23459 PMID: 26988598; PMCID: PMC4796901.

Meng F, Han Y, Srisai D, Belakhov V, Farias M, Xu Y, Palmiter RD, Baasov T, Wu Q. A new inducible genetic method reveals critical roles of GABA in the control of feeding and metabolism. Proc Natl Acad Sci U S A 2016 Mar 29; 113(13)3645-50. pii: 201602049. PMID: 26976589.

Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton Jr. A, Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line. Metabolism 2016 Apr;65(4):522-32. doi: 10.1016/j.metabol.2015.12.011. Epub 2015 Dec 29. PMID:26975544.

Xu Y, Chang JT, Myers Jr. MG, Xu Y, Tong Q. Euglycemia restoration by central leptin in Type 1 diabetes requires STAT3 signaling but not fast-acting neurotransmitter release. Diabetes 2016 Jan 28. pii: db151160. [Epub ahead of print]. PMID: 26822087.

Fan S, Dakshinamoorthy J, Kim ER, Xu Y, Huang C, and Tong Q. An indirect action contributes to c-fos induction in paraventricular hypothalamic nucleus by neuropeptide Y. Scientific Reports-Nature 2016 Jan 27;6:19980. doi: 10.1038/srep19980. PMID 26813148. PMCID: PMC4728490. 

Zhu L, Xu P, Cao X, Yang Y, Hinton A, Xia Y, Saito K, Yan X, Zou F, Ding F, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERα-PI3K cascade in pro-opiomelanocortin progenitor neurons regulates feeding and glucose balance in female mice. Endocrinology 2015 Dec; 156(12)4474-91. PMID: 26375425.

Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton A, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV inhibits AgRP/NPY neurons and activates POMC neurons in the arcuate nucleus. Neuroendocrinology 2015 August 25. [Epub ahead of print] PMID: 26337236.

Xu P, Cao X, Xu Y. Physical activity controlled by estrogen signals in the medial amygdala. Receptors & Clinical Investigation 2015; 2: e975. dio:10.14800/rci.975.

Xu P, Cao X, Xu Y. Targeting brain estrogen receptor for binge eating. Oncotarget 2015 August 22. [Epub ahead of print] PMID: 26309082.

Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton A, Zou F, Ding H, Xia Y, Yan C, Wu SP, Yang B, Feng Y, Clegg DJ, DiMarchi R, Khan SA, Tsai SY, DeMayo FJ, Wu Q, Tong Q, Xu Y. Estrogen receptor-α in medial amygdala neurons regulates body weight. The Journal of Clinical Investigation 2015 Jul 1;125(7):2861-76. PMID: 26098212.

Saito K, Cao X, He Y, Xu Y. Progress in the molecular understanding of central regulation of body weight by estrogens. Obesity. 2015 May;23(5):919-26. PMID: 25865677. PMCID: PMC4414873.

Zhu L, Zou F, Yang Y, Xu P, Saito K, Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042.

Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton A, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-Chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. British Journal of Pharmacology. 2015 Mar 27. doi: 10.1111/bph.13141. PMID: 25817043 [Epub ahead of print].

Wu Z, Kim ER, Sun H, Xu Y, Mangieri LR, Li DP, Pan HL, Xu Y, Arenkiel BR, Tong Q. GABAergic projections from lateral hypothalamus to paraventricular hypothalamic nucleus promote feeding. The Journal of Neuroscience. 2015 Feb 25; 35(8):3312-8. PMID: 25716832.

Shu G, Lu N, Zhu X, Xu Y, Du M, Xie Q, Zhu C, Xu Q, Wang S, Wang L, Gao P, Xi Q, Zhang Y, Jiang Q. Phloretin promotes adipocyte differentiation in vitro and improves glucose homeostasis in vivo. The Journal of Nutritional Biochemistry 2014 Dec;25(12):1296-308. PMID:25283330.

Scott MM, Xu Y, Elias CF and Williams KW. Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis. Frontiers in Neuroscience 2014 Dec 3;8:384. PMID:25520610. PMCID:PMC4253741.

Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton Jr. A, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. The Journal of Clinical Investigation 2014 August 26; 124(10):4351-4362.

Xu Y, Kim ER, Fan S, Xia Y, Xu Y, Huang C, Tong Q. Profound and rapid reduction in body temperature induced by the melanocortin receptor agonists. Biochemical and Biophysical Research Communications 2014 July 24 (Epub).

Berglund ED, Liu C, Sohn JW, Liu T, Kim MH, Lee CE, Vianna CR, Williams, KW, Xu Y(corresponding author), Elmquist JK. Serotonin 2C receptors in pro-opiomelanocortin neurons regulate energy and glucose homeostasis. The Journal of Clinical Investigation 2013 December 2; 123(12):5061-70. PMID: 24177424. PMCID: PMC3859401.

Xu Y, Wu Z, Sun H, Zhu Y, Kim ER, Lowell BB, Arenkiel BR, Xu Y and Tong Q. Glutamate mediates the function of melanocortin receptors 4 on Sim1 neurons in body weight regulation. Cell Metabolism 2013 December 3; 18(6):860-70. PMID: 24315371.

Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metabolism 2013 July 2; 18(1):86-89. PMID: 23823479. PMCID: PMC3752162.

Davis KE, Neinast MD, Sun K, Skiles WM, Dills JD, Zehr JA, Zeve D, Hahner LD, Cox DW, Gent LM, Xu Y, Wang ZV, Khan SA, Clegg DJ. The sexually dimorphic role of adipose and adipocyte estrogen receptors in modulating adipose tissue expansion, inflammation, and fibrosis. Molecular Metabolism 2013 Jun 4;2(3):227-42. PMID: 24049737. PMCID: PMC3773827.

Lee J, Moulik M, Fang Z, Saha P, Zou F, Xu Y, Nelson DL, Ma K, Moore DD, Yechoor VK. Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Molecular Cellular Biology 2013 Jun;33(11):2327-38. PMCID: PMC3648066. PMCID: PMC3648066.

Zhu L, Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O'Malley BW, Xu Y. Steroid receptor co-activator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology 2013 Jan;154(1):150-8. PMID: 23211707. PMCID: PMC3529365.

Tong Q and Xu Y. Central Leptin Regulation of Obesity and Fertility. Current Obesity Reports 2012 Dec 1;1(4):236-244. PMCID: PMC3519445.

Xu Y (corresponding author), Faulkner LD and Hill JW. Cross-talk between metabolism and reproduction: The Role of POMC and SF-1 Neurons. Frontiers in Systems and Translational Endocrinology 2012 Jan 4; 2: 1-13. PMCID: PMC3355979.

Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE, Zhang X, Zou F, Gent LM, Hahner LD, Khan SA, Elias CF, Elmquist JK and Clegg DJ. Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction. Cell Metabolism 2011 Oct 5;14(4):453-465. PMID: 21982706. PMCID: PMC3235745.

Xu Y (corresponding author), Elmquist JK and Fukuda M. Central nervous control of energy and glucose balance: focus on central melanocortin system. Annals of the New York Academy of Sciences 2011 Dec;1243(1):1-14. PMID: 22211889. PMCID: PMC3467098.

Sohn JW, Xu Y, Jones JE, Wickman K, Williams KW, Elmquist JK. Serotonin 2C receptor activates a distinct population of arcuate nucleus pro-opiomelanocortin neurons via TRPC channels. Neuron 2011 Aug 11;71(3):488-97. PMID: 21835345. PMCID: PMC3184528. 

Kim KW, Zhao L, Donata J , Khono D, Xu Y, Lee C, Parker K, Elmquist JK. Steroidogenic Factor 1 Directs Programs Regulating Diet-Induced Thermogenesis and Leptin Action in the Ventral Medial Hypothalamic Nucleus. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10673-8. PMID: 21636788. PMCID: PMC3127910.

Marino JS, Xu Y, Hill JW. Central insulin and leptin-mediated autonomic control of glucose homeostasis. Trends Endocrinol Metab. 2011 July;22(7):275-85. PMID: 21489811. PMC Journal - In Process.

Kim KW, Sohn JW, Kohno D, Xu Y, Williams K, Elmquist JK. SF-1 in the ventral medial hypothalamic nucleus: A key regulator of homeostasis. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):219-23. PMID: 2111025. PMCID: PMC3057357.

Xu Y, Berglund DE, Sohn JW, Holland WL, Chuang JC, Fukuda M, Rossi J, Williams KW, Jones JE, Zigman JM, Lowell BB, Scherer PE and Elmquist JE. 5-HT2CRs Expressed by Pro-opiomelanocortin Neurons Regulate Insulin Sensitivity in Liver. Nature Neuroscience. 2010 Dec; 1(12):1457-9. PMID: 21037584. PMCID: PMC3059249.

Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB and Elmquist JK. A Serotonin and Melanocortin Circuit Mediates d-Fenfluramine Anorexia. The Journal of Neuroscience. 2010 Nov 3;30(44):14630-4. PMID: 21048120. PMCID: PMC3466475.