Robert Britton Lab

Interplay between Intestinal Hormones and the Microbiota


How ingested microbes, such as probiotics, have systemic effects on host physiology remain understood.  Recent work has suggested that the interaction with the microbiome and intestinal enteroendocrine cells, the producers of powerful hormones such as serotonin and GLP-1 from the gut, may play a significant role.  To study microbiome:enteroendocrine cell interactions, we along with three other labs at BCM developed human intestinal organoids can have increased enteroendocrine


Selected Publications


Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019;8(2):209-229. doi: 10.1016/j.jcmgh.2019.04.010. Epub 2019 Apr 25. PMID: 31029854; PMCID: PMC6664234.

LeValley SL, Tomaro-Duchesneau C, Britton RA. Degradation of the Incretin Hormone Glucagon-Like Peptide-1 (GLP-1) by Enterococcus faecalis Metalloprotease GelE. mSphere. 2020;5(1):e00585-19. Published 2020 Feb 12. doi:10.1128/mSphere.00585-19

Tomaro-Duchesneau, C., LeValley, S. L., Roeth, D., Sun, L., Horrigan, F. T., Kalkum, M., Hyser, J. M., & Britton, R. A. (2020). Discovery of a bacterial peptide as a modulator of GLP-1 and metabolic disease. Scientific reports, 10(1), 4922