Monica Pillon Lab



Selected Publications


Pillon MC*,§, Frazier MN§, Dillard LB§, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE*. “Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15.” Nature Communications. 2021 January 27; 12 (1): 636. PMID: 33504779.

Pillon MC§, Goslen KH§, Gordon J, Wells ML, Williams JG, Stanley RE. “It takes two Las1 HEPN endoribonuclease domains to cut the RNA correctly.” The Journal of Biological Chemistry. 2020 May 1; 295 (18): 5857-5870. PMID: 32220933.

Pillon MC, Hsu AL, Krahn JM, Williams JG, Goslen KH, Sobhany M, Borgnia MJ, Stanley RE. “Cryo-EM Reveals Active Site Coordination Within a Multienzyme pre-rRNA Processing Complex.” Nature Structural and Molecular Biology. 2019 September; 26 (9): 830-839. PMID: 31488907.

Pillon MC, Sobhany M, Stanley RE. “Characterization of the Molecular Crosstalk within the Essential Grc3/Las1 pre-rRNA Processing Complex.” RNA. 2018 May; 24 (5): 721-738. PMID: 29440475.

Pillon MC, Sobhany M, Borgnia MJ, Williams JG, Stanley RE. “Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.” Proceedings of the National Academy of Sciences of the United States of America. 2017 July 11; 114 (28): E5530-E5538. PMID: 28652339.

Pillon MC, Babu VMP, Randall JR, Cai J, Simmons LA, Sutton MD, Guarné A. “The sliding clamp tethers the MutL endonuclease domain to DNA.” Nucleic Acids Research. 2015 December 15; 43 (22): 10746-10759. PMID: 26384423.

Pillon MC, Dubinsky M, Johnston RN, Liu SL, Guarné A. “Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability.” DNA Repair. 2013 October; 12 (10): 864-869. PMID: 23916559.

Pillon MC, Miller JH, Guarné A. “The endonuclease domain of MutL interacts with the β sliding clamp.” DNA Repair. 2011 January 2; 10 (1): 87-93. PMID: 21050827.

Pillon MC, Lorenowicz JJ, Ukelmann M, Klocko AD, Mitchell RR, Chung YS, Modrich P, Walker GC, Simmons LA, Friedhoff P, Guarné A. “Structure of the endonuclease domain of MutL: unlicensed to cut.” Molecular Cell. 2010 July 9; 39 (1): 145-151. PMID: 20603082.