Our philosophy emphasizes state-of-the-art patient treatment, research and training programs that focuses on improving quality of life for renal patients.
Division Overview
Our Division of Pediatric Nephrology specialists at Baylor College of Medicine evaluate and treat children with congenital or acquired kidney diseases at Texas Children’s Hospital.
Each provider has outpatient clinics where patients with kidney disorders are diagnosed and provided therapeutic intervention, education, and multidisciplinary support including renal nutrition, social work and child life expertise.
Our providers also care for inpatients and provide consultations at Texas Children's Hospital main campus. We provide intensive care unit nephrology services including Continuous Renal Replacement Therapy (CRRT) and Extracorporeal Liver Support (ELS).
Active clinical care and research programs for patients requiring chronic and acute dialysis, apheresis and renal transplant are available at Texas Children's Kidney Transplant Program.
We offer an ACGME-accredited program for fellowship training. The three-year curriculum provides exposure to a variety of acute and chronic cases within an exceptionally well-rounded program that prepares the pediatric physician/scientist for a successful career in academic medicine or clinical care.
Division Research
Our faculty members conduct research through clinical investigation, clinical trials and laboratory studies. Clinical studies are performed through the departmental Research Resource Office. The following information details the faculty's interests in the areas of nephrology research.
Dr. Bekheirnia is a clinical and molecular geneticist who sees both pediatric and adult patients with inherited kidney disease. He has a specific clinical interest in diagnosis and management of the diseases and anomalies of the kidney and genitourinary tract (CAKUT). CAKUT is a leading cause of end stage renal disease (ESRD) in children, accounting for 50% of such cases in the pediatric population. The complications from CAKUT can continue into adulthood. Identification of new genes allows better diagnosis, prevention, and counseling of the patients. He also performs genetic studies involving novel genes associated with nephrotic syndrome, and hereditary nephropathy (Alport syndrome).
Dr. Braun’s research focuses on immune-mediated mechanism of renal injury. Using murine models of lupus nephritis and membranoproliferative glomerulonephritis (MPGN), his laboratory is investigating the mechanisms by which the complement system both initiates renal injury and alters the host adaptive immune response to glomerular damage. The current focus of this work is on the role of the receptors for the complement cleavage products C3a and C5a, as well as the effects of sub-lytic membrane attack complex deposition on renal parenchymal cell responses. Dr. Braun’s clinical research interests are in the areas of complement mediated glomerular diseases, MPGN in particular, and disease recurrence in renal allografts.
Dr. Braun is the local principal investigator for the midwest pediatric nephrology consortium (MWPNC)'s NIH funded CureGN study.
Dr. Brewer’s research focuses on clinical investigation of kidney diseases in children and adolescents and currently includes studies of fibroblastic growth factor 23 and dysfunctional mineral metabolism as potential cardiovascular risk factors in pediatric patients with end-stage renal disease. She participates as institutional principal investigator in national multi-center clinical investigations, such as the NIH-sponsored randomized, double-blind, placebo-controlled trial of antimicrobial prophylaxis in children with vesicoureteral reflux and urinary tract infection.
Dr. Elenberg is a national expert in cystinosis; in 2009, she received a grant from the Cystinosis Research Network to study quality of life in patients with cystinosis. She is currently in the planning stage of a major study aimed at developing a better drug that will improve quality of life for patients with cystinosis.
Dr. Michael is involved in clinical research. She has expertise in performing systematic reviews, including a recent review of interventions for hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). She studies pediatric renal transplant outcomes and has published on long-term dual immunosuppression at Texas Children's for the last 20 years in collaboration with Dr. Brewer. Dr. Michael is also a co-investigator for a midwest pediatric nephrology consortium (MWPNC) study involving atypical HUS (including the KidCOM registry of complemented mediated kidney diseases in children), as well as for a collaborative patient reported outcomes study in pediatric chronic kidney disease (SONG-Kids).
Dr. Malatesta has a research interest in cardiovascular complications of children with chronic kidney disease, mainly during dialysis. She is a co-investigator for a midwest pediatric nephrology consortium (MWPNC) study involving sickle cell nephropathy and patient reported outcomes in dialysis (ASK-KIDD).
Dr. Shah is a co-investigator for the midwest pediatric nephrology consortium (MWPNC) study involving IgA nephropathy.
Dr. Srivaths’ research focus is investigating cardiovascular morbidity associated with end-stage renal disease in children. He and his colleagues have completed a pilot project assessing prevalence and progression of cardiac calcifications in children receiving hemodialysis. He is expanding this research to assess cardiac calcifications in children receiving peritoneal dialysis and is also undertaking a project comparing calcifications and vascular compliance in children with end-stage renal disease.
Dr. Srivaths is the local principal investigator for the NIH funded CKiD study.
Dr. Schwartz is a co-investigator in the Children's Hospital Association Standardizing Care to Improve Outcomes in Pediatric ESRD (SCOPE) Collaborative, whose goal is to improve care and reduce infection rates in children on peritoneal and hemodialysis.
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