The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be explored.
Alternative pathways of RNA processing are regulated in response to signaling cues often coordinating expression of gene networks in response to physiological change including in development and disease.
We are interested in understanding the mechanisms and consequences of this regulation, from how RNA binding proteins and signaling pathways coordinate RNA processing networks to the functional consequences of the different protein isoforms that are expressed in different cell states.
We also investigate the pathogenic mechanisms of myotonic dystrophy, type 1 (DM1), an autosomal dominant neuromuscular disorder affecting multiple tissues including muscle, heart and the central nervous system. The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express adult splicing patterns causes primary features of the disease.
The understanding of the molecular mechanisms of DM1 pathogenesis has led to development of several therapeutic approaches some of which are being testing using mouse models established in the lab.
These investigations utilize a combination of cell culture and genetic models including transgenic and knock out mouse lines for RNA binding proteins, CRISPR-derived mouse lines in which specific alternative exons are removed, and DM1 mouse models.
The overlapping areas of investigation in the lab lead to synergistic and collaborative interactions in which knowledge gained in one area fosters progress in the others.
Cooper Lab News
Abstracts submitted by Diana, Paul, Ashish were selected for talks award at the biannual IDMC12 meeting in Gothenburg, Sweden and Paul won award for best talk.
Ashish Rao was awarded a two-year predoctoral fellowship from the Myotonic Dystrophy Foundation starting January 2018 through December 2020.
Paul Pang was awarded a three-year predoctoral F31 NRSA fellowship from the NIH to start in 2018 through 2021.
Diana Cox was awarded a three-year predoctoral F31 NRSA fellowship from the NIH to starting in 2018 through 2021.
Paul won best poster award at the 2019 IMBS graduate program annual retreat.
Diana and Paul signed up for the 3MT Three Minute Thesis competition sponsored by Queensland University and Diana won first place in the BCM competition.
Ginny Morriss¹ accepted a tenure track assistant professor position at the University of Mary Washington in Fredericksburg, Va. starting July 2019.
Ashish, Paul and Diana will all be presenting their submitted abstracts all selected for oral presentations at the biennial international Myotonic Dystrophy meeting in Gothenburg, Sweden June, 2019
Pang Paul defended his Ph.D. thesis May 24, 2019 and will be moving to Stanford University for his postdoctoral training in the lab of Dr. Joseph Wu.
Ph.D. students Matt Penna (MSTP, TBMM) and Sara Johnson (MCB) join the lab in 2019.
New lab staff member Lihua Huang join the lab June 2019