About the Lab
Our body needs a skeleton to move but also for a number of important physiological functions necessary for every day’s life. Genetic diseases, accidents or different types of cancers can deleteriously impact the skeleton and its functions, and it is also likely that an abnormal skeleton alters normal body development or function. Understanding how bones form, grow, stay resilient during many years and repair after injury is thus important to uncover the new therapeutic targets necessary for prevention or improved management of skeletal conditions affecting the quality of life our aging population.
Our research program combines the use of genetic mouse models, pharmacological approaches and gain or loss-of-function strategies to investigate mechanisms of bone development, repair and aging. Ongoing work focuses on the skeletal maladies in children with neurofibromatosis type 1 (NF1), on the role of the autonomic nervous system in the regulation of bone remodeling, and on the formation and aging of the joints and intervertebral discs.