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Damian Young Lab



Wach, Jean-Yves; Chamikuri, Srinivas; Sheehan, Patrick; Young, Damian W. “Stereodivergent strategy toward enantioenriched bicyclic hybrid Csp2-Csp3 fragments”, submitted to the Journal of Organic Chemistry.

Young, Damian W. “Considerations Related to Small-molecule Screening Collections” High Throughput Screening Methods: Evolution and Refinement, The Royal Society of Chemistry, in press.

Wang, Yikai; Wach, Jean-Yves; Sheehan, Patrick; Zhong, Cheng; Zhan, Chenyang; Harris, Richard; Almo, Stephan. A.; Bishop. Joshua; Haggarty, Stephan J.; Ramek; Alexander O’Herin, Connor; Koehler, Angela N.; Hung, Alvin W.; Young, Damian W. “Diversity-oriented synthesis as a strategy for fragment evolution against GSK3b” ACS Med. Chem. Lett., 2016, 7, 852-6.

Wang, Yikai; Jimenez, Miguel; Sheehan Patrick; Zhong Cheng; Hung Alvin W., Tam Chung Pong, and Young, Damian W. “Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes” Org Lett. 2013, 15, 1218-21.

Comins Daniel L., Higuchi Kazuhiro, Young, Damian W. “Dihydropyridine preparation and application in the synthesis of pyridine derivatives” In Alan R. Katritzky, (ed.), Advances in Heterocyclic Chemistry, Academic Press, 2013, Elsevier Inc., pp.175–236.

Yuan, Yuan; Hartland, Kate; Boskovic, Zarko; Wang, Yikai; Walpita, Deepika; Zhong, Cheng; Young Damian W., Kim Young-Kwon, Tolliday Nicola J., Schreiber Stuart L.; and Wagner Bridget K. “Chemical complementation of Pdx1 causes acquisition of beta cell-like characteristics in a human ductal cell line” Chemistry and Biology, 2013, 12, 1513-22.

Zhong, Cheng; Wang, Yikai; O’Herin, Conor; Young, Damian W. “Synthesis of Substituted morpholines using stereodivergent aza-Michael reactions catalyzed by Brønsted acids” ACS Catalysis 2013, 3, 643-6.

Zhong, Cheng; Wang, Yikai; Hung, Alvin W., Schreiber, Stuart L.; Young, Damian W. “Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts” Org. Lett. 2011,13, 5556-9.

Pandya, Bhaumik A.; Dandapani, Sivaraman; Duvall, Jeremy R.; Rowley, Ann; Mulrooney, Carol A.; Ryba, Troy; Dombrowski, Michael; Harton, Marie; Young, Damian W.; Marcaurelle, Lisa A. “Practical asymmetric synthesis of β-hydroxy-γ-amino acids via complimentary aldol reactions” Tetrahedron, 2011, 67, 6131-7.

Wang, Yikai; Jimenez, Miguel; Hansen, Anders S., Raiber, Eun-Ang, Schreiber, Stuart L., and Young, Damian W. “Control of olefin geometry in macrocyclic ring-closing metathesis reactions using a removable silyl group” J. Am. Chem. Soc. 2011, 133, 9196-9.

Marcaurelle, Lisa A.; Comer, Eamon; Dandapani, Sivaraman; Duvall, Jeremy R.; Gerard, Beadouin Kesavan, Sarathy; Lee, Maurice, D.; Liu, Haibo; Lowe, Jason T.; Marie, Jean-Charles; Mulrooney, Carol A.; Pandya, Bhaumik A.; A. Rowley, Ann; Ryba, Troy; Suh, Byung-Chul; Wei, Jingquing; Young, Damian W.; Akella, Lakshmi B.; Ross, Nathan T.; Zhang, Yan-Ling; Fass, Daniel M.; Reis, Surya A.; Zhao, Wen-Ning; Haggarty, Stephen J.; Palmer, Michelle; Foley, Michael A. “ An Aldol-based build/couple/pair strategy for the synthesis of medium-and large sized rings: discovery of macrocyclic histone deacetylase inhibitors” J. Am. Chem. Soc., 2010, 132, 16962-76.

Dancik, Vlado; Seiler, Kathleen, P.; Young, Damian W.; Schreiber, Stuart L. Clemons, Paul A. “Distinct biological network properties between the targets of natural products and disease genes” J. Am. Chem. Soc. 2010, 132, 9259-61.

Young, Damian W. “An Upfront Investment” Nat. Chem. Bio., 2010, 5, 175.

Kelly, Ann W.; Wei, Jingqiang; Kesavan, Sarathy; Marie, Jean-Charles; Windmon, Nicole; Young, Damian W. and Marcaurelle, Lisa A. “Accessing skeletal diversity using catalyst control: formation of n and n+1 macrocyclic triazole rings” Org. Lett. 2009,11, 2257-60.