Theodore Wensel Lab



Wensel, T. G. (2020) Phosphoinositides in Retinal Function and Disease. Cells. 2020 Apr 2;9(4). pii: E866. doi: 10.3390/cells9040866. PMID: 32252387. PMCID pending. 

Agosto, Melina A., Wensel, T. G. (2020) LRRTM4 is a member of the transsynaptic complex between rod photoreceptors and bipolar cells. J. Comp. Neurol., 2020;1–13. DOI: 10.1002/cne.24944. Pubmed Central in process.

Wensel, T.G. (2020) Phototransduction in Vertebrate Rods and Cones, Chapter in The Senses: A Comprehensive Reference 2nd Edition, Bernd Fritzsch, Editor in Chief, ISBN: 9780128054086, Academic Press.

Go, Y.-M., Zhang, J. Fernandes, J., Litwin, C., Chen, R., Wensel, T.G., Jones, D. P., Cai, J., Chen, Y. (2020). MTOR-initiated Metabolic Switch and Degeneration in the Retinal Pigment Epithelium. FASEB J. Jul 28. doi: 10.1096/fj.202000612R. Online ahead of print. PMID: 32721041.

Dosey, T. L., Wang, Z, Fan, G., Zhang, Z., Serysheva,I. I. Chiu, W. Wensel, T.G. (2019) TRPV2 Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat. Struct. Mol. Biol. Jan;26(1):40-49. doi 10.1038/s41594-018-0168-8. PMCID:PMC6458597

He, F., Nichols, R. M., Kailasam, L., Wensel, T. G., Agosto, M. A. (2019) Critical role for phosphatidylinositol-3 kinase Vps34/PIK3C3 in ON-bipolar cells. Invest. Ophthalmol. Vis. Sci. 60(8):2861-2874. PMCID:PMC6607926

Tang, J., Robichaux, M. A., Wu, K. L., Pei, J., Nguyen, N. T., Zhou, Y., Wensel, T. G., and Xiao, H. (2019) Single-Atom Fluorescence Switch: A General Approach towards Visible Light-Activated Dyes for Biological Imaging. Published online, J. Am Chem. Soc. 141:14699-14706. PMCID: PMC6812504.

Robichaux, M. A., Potter, V. L., Zhang, Z., He, F., Liu, J., Schmid, M. F., Wensel, T. G. (2019) Defining the layers of a sensory cilium with STORM and cryo-electron nanoscopy. Proc. Nat. Acad. Sci. USA. 116:23562-23572. PMCID: PMC6876244.

Terrón-Díaz,M. E., Agosto, M. A., Lichtarge, O. Wensel, T. G. (2019) Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. Published on-line J. Biol. Chem. PMCID: PMC6916503.

Dharmat, R. Eblimit, A. Robichaux, M. Zhang, Z., Nguyen, T.-M., Jung, S., He, F., Jain, A., Li, Y., Qin, J., Overbeek, P., Roepman, R., Mardon, G., Wensel, T., Chen, R. (2018) SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. in press J. Cell Biol.217(8):2851-2865. doi: 10.1083/jcb.201712117. Epub 2018 Jun 13. PMID: 29899041; PubMed Central PMCID: PMC6080925

Agosto MA, Anastassov IA, Robichaux MA, Wensel TG. 2018. A large endoplasmic reticulum-resident pool of TRPM1 in retinal ON bipolar cells. eNeuro. doi: 10.1523/ENEURO.0143-18.2018. PMCID: PMC6051591

Agosto, M. A., Anastassov, I. A., Wensel, T. G. (2018) Differential epitope masking reveals synapse-specific complexes of TRPM1. Vis. Neurosci.35:E001. PMCID:PMC5788301

Yu, B., Egbejimi,A., Dharmat, R., Xu,P.1, Zhao, Z., Long, B., Miao,H., Chen,R., Wensel, T. G., Cai, J., Chen, Y. (2018) Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium. Sci. Signal. 11(532). pii: eaag3315 doi:10.1126/scisignal.aag3315.11(532). PMID:29844054; PubMed Central PMCID:PMC6198651.

Tse DY, Kim SJ, Chung I, He F, Wensel TG, Wu SM. (2017) The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int J Ophthalmol.10:1361-1369. PMCID: PMC5596219.

Galaz-Montoya M, Wright SJ, Rodriguez GJ, Lichtarge O, Wensel TG. β(2)-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017 Jun 16;292(24):9967-9974. doi: 10.1074/jbc.M117.787119. Epub 2017 Apr 25. PubMed PMID: 28442571; PubMed Central PMCID: PMC5473248.

Wensel TG, Zhang Z, Anastassov IA, Gilliam JC, He F, Schmid MF, Robichaux MA. Structural and molecular bases of rod photoreceptor morphogenesis and disease. Prog Retin Eye Res. 2016 Jun 22. pii: S1350-9462(16)30041-6. doi: 10.1016/j.preteyeres.2016.06.002. [Epub ahead of print] Review. PMID: 27352937

He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG. Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Rep. 2016 Jun 1;6:26978. doi: 10.1038/srep26978. PMID: 27245220

Sung YM, Wilkins AD, Rodriguez GJ, Wensel TG, Lichtarge O. Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3539-44. doi: 10.1073/pnas.1516579113. Epub 2016 Mar 15. PMID: 26979958

Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem. 2015 May 15;290(20):12833-43. doi: 10.1074/jbc.M115.647636. Epub 2015 Mar 25. Erratum in: J Biol Chem. 2015 Jul 10;290(28):17131-2. PMID: 25809480

Kang HJ, Wilkins AD, Lichtarge O, Wensel TG. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors J Biol Chem. 2015 Jan 30;290(5):2870-8. doi: 10.1074/jbc.M114.622233. Epub 2014 Dec 17. PMID: 25519912

Sandoval IM, Price BA, Gross AK, Chan F, Sammons JD, Wilson JH, Wensel TG. Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. PLoS One. 2014 Sep 29;9(9):e108135. doi: 10.1371/journal.pone.0108135. eCollection 2014. PMID: 25264759

Kang HJ, Menlove K, Ma J, Wilkins A, Lichtarge O, Wensel TG. "Selectivity and Evolutionary Divergence of Metabotropic Glutamate Receptors for Endogenous Ligands and G Proteins Coupled to Phospholipase C or TRP Channels." J Biol Chem. 2014 September 5:M114.574483. Pubmed PMID:25193666

Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG. "Oligomeric State of Purified TRPM1, a Protein Essential for Dim Light Vision." J Biol Chem. 2014 August 11:M114.593780. Pubmed PMID:25112866

Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. "The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration." PLoS Biol. 2014 April 29;12(4):e1001847. Pubmed PMID: 24781186

Arshavsky VY, Wensel TG.. "Timing is everything: GTPase regulation in phototransduction.." Ophthalmol. Vis. Sci.. 2013 November 21;54(12):7725-33. Pubmed PMID: 24265205

Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG. "Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration.." Cell. 2012 November 21;151(5):1029-41. Pubmed PMID: 23178122

Price BA, Sandoval IM, Chan F, Nichols R, Roman-Sanchez R, Wensel TG, Wilson JH. "Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant.." PLoS ONE. 2012;7(11):e49889. Pubmed PMID: 23185477

Price BA, Sandoval IM, Chan F, Simons DL, Wu SM, Wensel TG, Wilson JH. "Mislocalization and Degradation of Human P23H-Rhodopsin-GFP in a Knockin Mouse Model of Retinitis Pigmentosa.." Invest. Ophthalmol. Vis. Sci.. 2011 December;52(13):9728-36. Pubmed PMID: 22110080

Gilliam JC, Wensel TG. "TRP channel gene expression in the mouse retina.." Vision Res.. 2011 December 8;51(23):2440-52. Pubmed PMID: 22037305

Chan F, Hauswirth WW, Wensel TG, Wilson JH. "Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice.." Nucleic Acids Res.. 2011 August 1;39(14):5955-66. Pubmed PMID: 21478169

Baehr W, Wensel T, Hageman G, Wu S, Zack D. "Retinal ganglion cells: Development, function, and disease.." Vision Res.. 2011 January 28;51(2):223. Pubmed PMID: 21251506

Moiseenkova-Bell V, Wensel TG. "Functional and Structural Studies of TRP Channels Heterologously Expressed in Budding Yeast.." Adv. Exp. Med. Biol.. 2011;704:25-40. Pubmed PMID: 21290288

Mojumder DK, Concepcion FA, Patel SK, Barkmeier AJ, Carvounis PE, Wilson JH, Holz ER, Wensel TG. "Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye.."Invest. Ophthalmol. Vis. Sci.. 2010 November;51(11):5796-803. Pubmed PMID: 20505203

Rodriguez GJ, Yao R, Lichtarge O, Wensel TG. "Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors.." Proc. Natl. Acad. Sci. U.S.A.. 2010 April 27;107(17):7787-92. Pubmed PMID: 20385837

Budzynski E, Gross AK, McAlear SD, Peachey NS, Shukla M, He F, Edwards M, Won J, Hicks WL, Wensel TG, Naggert JK, Nishina PM. "Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice.." J. Biol. Chem.. 2010 May 7;285(19):14521-33. Pubmed PMID: 20207741

Jeffrey BG, Morgans CW, Puthussery T, Wensel TG, Burke NS, Brown RL, Duvoisin RM. "R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells.." Vis. Neurosci.. 2010 March;27(1):9-17. Pubmed PMID: 20100392

Mancuso JJ, Qian Y, Long C, Wu GY, Wensel TG. "Distribution of RGS9-2 in neurons of the mouse striatum.."J. Neurochem.. 2010 February;112(3):651-61. Pubmed PMID: 19912469

Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ. "A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.." Cell. 2009 September 4;138(5):947-60. Pubmed PMID: 19737521

Mojumder DK, Wensel TG. "Topical mydriatics affect light-evoked retinal responses in anesthetized mice.." Invest. Ophthalmol. Vis. Sci.. 2010 January;51(1):567-76. Pubmed PMID: 19661232

Mojumder DK, Qian Y, Wensel TG. "Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling.." J. Neurosci.. 2009 June 17;29(24):7753-65. Pubmed PMID: 19535587

Mancuso JJ, Larson AM, Wensel TG, Saggau P. "Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging.." J Biomed Opt. 2009 May;14(3):34048. Pubmed PMID: 19566340