Salih Wakil Lab



Abu-Elheiga L, Wu H, Gu Z, Bressler R, Wakil SJ. "Acetyl-CoA Carboxylase 2-/- Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary and de Novo Lipogenic Conditions.." J. Biol. Chem.. 2012 April 6;287(15):12578-88. Pubmed PMID: 22362781

Zhang W, Chakravarty B, Zheng F, Gu Z, Wu H, Mao J, Wakil SJ, Quiocho FA. "Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-{gamma}-linolenic acid.." Proc. Natl. Acad. Sci. U.S.A.. 2011 September 20;108(38):15757-62. Pubmed PMID: 21908709

Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Park Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. "Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins.." J. Med. Chem.. 2011 July 14;54(13):4923-7. Pubmed PMID: 21561152

Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. "Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease.." Proc. Natl. Acad. Sci. U.S.A.. 2009 November 3;106(44):18831-6. Pubmed PMID:19850873

Mao J, Yang T, Gu Z, Heird WC, Finegold MJ, Lee B, Wakil SJ. "aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose tissues.." Proc. Natl. Acad. Sci. U.S.A.. 2009 October 13;106(41):17576-81. Pubmed PMID:19805143

Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. "A small molecule that blocks fat synthesis by inhibiting the activation of SREBP.." Chem. Biol.. 2009 August 28;16(8):882-92. Pubmed PMID: 19716478

Wakil SJ, Abu-Elheiga LA. "Fatty acid metabolism: target for metabolic syndrome.." J. Lipid Res.. 2009 April;50:S138-43. Pubmed PMID: 19047759

Essop MF, Camp HS, Choi CS, Sharma S, Fryer RM, Reinhart GA, Guthrie PH, Bentebibel A, Gu Z, Shulman GI, Taegtmeyer H, Wakil SJ, Abu-Elheiga L. "Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice.." Am. J. Physiol. Heart Circ. Physiol.. 2008 July;295(1):H256-65. Pubmed PMID: 18487439

Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A, Distefano A, Hwang YJ, Reznick RM, Codella R, Zhang D, Cline GW, Wakil SJ, Shulman GI. "Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity.." Proc. Natl. Acad. Sci. U.S.A.. 2007 October 16;104(42):16480-5. Pubmed PMID: 17923673

Mao J, DeMayo FJ, Li H, Abu-Elheiga L, Gu Z, Shaikenov TE, Kordari P, Chirala SS, Heird WC, Wakil SJ. "Liver-specific deletion of acetyl-CoA carboxylase 1 reduces hepatic triglyceride accumulation without affecting glucose homeostasis.." Proc. Natl. Acad. Sci. U.S.A.. 2006 May 30;103(22):8552-7. Pubmed PMID: 16717184