Michael Lewis Lab





Iyer, V., Klebba, I., McCready, J., Arendt, L.M., Betancur-Boissel, M, Wu, M-F., Zhang, X., Lewis, M.T.,and Kuperwasser, C. Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone marrow-derived monocytes. Can Res. 2012. Online. PMID: 22467173.

Hatzikirou, H., Chauviere, A., Bauer, A.L., Leier, A., Lewis, M.T., Macklin, P., Marquez-Lago, T.T., Bearer, E.L. and Cristini, V. Integrative physical oncology. Wiley Interdiscip Rev Syst Biol Med. 2012(1):1-14. PMID: 21853537.

Guven, A., Rusakova, IA, Lewis, M.T., Wilson Li. Cisplatin @ US-tube carbon nanocapsules for enhanced chemotherapeutic delivery. Biomaterials. 2012; 33(5): 1455-61.




Visbal, A.P., LaMarca, H.L., Villanueva, H., Toneff, M.J., Li, Y., Rosen, J.M., and Lewis, M.T. Altered differentiation and Paracrine stimulation of mammary epithelial cell proliferation by conditionally activated smoothened. Dev Biol. 2011, 352(1):116-27. PMID: 21276786

Selever, J., Gu, G., Lewis, M.T., Beyer, A., Herynk M.H., Covington, K.R., Tsimelzon, A., Dontu, G., Provost, P., Di Pietro, A., Boumendjel, A., Albain, K., Miele, L., Weiss, H.L., Barone, I., Ando, S and Fuqua, S.A. Dicer-mediated upregulation of BCRP confers Tamoxifen resistance in human breast cancer cells. Clin Cancer Res 2011; 17(20):6510-21. PMID 21878538.

Heckman-Stoddard, B.M., Vargo-Gogola, T., Herrick, M.P., Visbal, A. P., Lewis, M.T., Settleman, J., Rosen., J.M. P190A RhoGAP is required for mammary gland development. Dev. Biol. 2011; 360(1):1-10. PMID: 21945077. PMCID: PMC3215776.

Dong, J., Huang, S., Caikovski, M., Ji, S., McGrath, A., Custorio, M.G., Creighton, C.J., Maliakkal, P., Bogoslovskaia, E., Du., Z., Zhang, X., Lewis, M.T., Sablitzky, F., Brisken, C and Li, Y. ID4 regulates mammary glad development by suppressing p38MAPK activity. Development, 2011; 138(23):5247-56.




Zhu, X., Zhou, X., Lewis, .M.T., Xia, L., Wong, S. Cancer stem cell, niche and EGFR decide tumor development and treatment response: A bio-computational simulation study. J. Thero. Biol. 2011 Jan 21;269(1): 138-49. Epub 2010 Oct 20. PMID 20969880. NIHMSID: NIHMS251860.

Rodriguez, A.A., Makris, A., Wu., M.F., Rimawi, M., Froehlich, A., Dave, B., Hilsenbeck, S.G., Chamness, G.C., Lewis, M.T., Dobrolecki, L. E., Jain, D., Sahoo, S., Osborne, C.K., and Chang, J.C. DNA repair signature is associated with anthracycline response in triple negative breast cancer patients. Breast Cancer Res Treat., (2010) Aug; 123(1): 189-96. Epub 2010 Jun 26. PMID: 20582464

Litzenburger, B.C., Creighton, C.J., Tsimelzon, A., Chan, B.T., Hilsenbeck, S.G., Wang, T., Carboni, J.M., Gottardis, M.M., Huang, F., Chang, J.C., Lewis, M.T., Rimawi, M.F., and Lee, A.V. High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy. Clin Cancer Res. 2011 Apr 15;17(8):2314-27. Epub 2010 Dec 22. PMID: 21177763. NIHMSID: NIHMS260804.

Lewis, M.T. (2010) The more things change...the more things change: developmental plasticity of tumor-initiating mammary epithelial cells. Breast Cancer Research 12:101. PMCID: PMC2880417.

Klopp, A.H., Lacerda, L., Gupta, A., Debeb, B.G., Solley, T., Li,L., Spaeth, E., Xu, W., Zhang, X.,Lewis, M.T., Reuben, J.M., Krishnamurthy, S., Ferrai, M., Gaspar, R., Buchholz, T.A., Cristofanilli, M., Marini, F., Andreeff, M., and Woodward, W.A. Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells. PLoS ONE, (2010) August 1; 5(8): e12180. PMCID: PMC2922340.

Franco, H.L. Lee, K.Y., Rubel, C.A., Creighton, C.J., White, L.D., Broaddus, R.R., Lewis, M.T., Lydon, J.P., Jeong, J-W., and DeMayo, F. J. Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse. Biol Reprod; (2010) May; 27(5):991-9. Epub 2010 Feb 3. PMID: 20130264.

Debeb, B.G., Zhang, X, Krishnamurthy, S., Gao, H., Cohen, E., Li, L., Rodriguez, A.A., Landis, M.D., Lucci, A., Ueno, N.T., Robertson, F., Xu, W., Lacerda, L., Buchholz, T.A., Cristofanilli, M., Reuben, J.M., Lewis, M.T., and Woodward, W.A. Characterizing cancer cells with cancer stem cell-like features in 293T human embryonic kidney cells. Mol Cancer, (2010) Jul 8;9:180. PMCID: 20615238. PMCID: PMC2915978.

Chang, H., Li, Q., Moraes, R.C., Lewis, M.T., and Hamel, P.A. Activation of ERK by sonic hedgehog independent of canonical hedgehog signaling. Intl J. of Biochem & Cell Bio, (2010) Sep; 42(9): 1462-71. Epub 2010 May 6. PMID: 20451654

Visbal, A.P.,and Lewis, M.T. Hedgehog signaling in the normal and neoplastic mammary gland. Curr Drug Targets. (2010) September 1; 11(9): 1103-11. PMID: 20545610




Yang, W.T.*, Lewis, M.T.*, Hess, K., Wong, H., Tsimelzon, A., Karadag, N., Cairo, M., Wei, C., Meric-Bernstam, F., Brown, P., Arun, B., Hortobagyi, G.N., Sahin, A., and Chang, J.C. (2009) Decreased TFGβ signaling and increased COX2 expression in high risk women with increased mammographic breast density. Breast Cancer Res Treat, * Co-first authors. Jan; 119(2): 305-14. Epub 2009 Feb 25. PMID: 19241157

Moraes R.C., Chang H., Harrington N., Landua J., Prigge J., Lane T., Wainright B., Hamel P.A., and Lewis M.T. (2009) Patched1 functions locally to regulate mammary ductal morphogenesis and systemically to regulate ductal elongation. Development Epub 2/6/2009. PMID: 19297414. Impact factor 7.29.

Lewis, M.T. and Wicha, M.S. (2009) Tumor-initiating cells and treatment resistance: How goes the war? J. Mammary Gland Biol. Neoplasia 14:1-2. (Commentary)

Landua, J.D., Visbal, A.P, and Lewis, M.T. Methods for preparing fluorescent and neutral red-stained whole mounts of mouse mammary glands. (2009) J Mammary Gland Biol Neoplasia. 2009 Dec; 14(4): 411-5. Nov. 24, 2009 epub ahead of print. PMID: 19936989. PMCID: PMC3038127.

Kaipparettu B.A., Dobrzycka K.M., Britton O., Lee A.V., Herron A. J., Li Y., Lewis M.T., Medina D., and Oesterreich S. (2009) Scaffold attachment factor B1 (SAFB1) heterozygosity does not collaborate with Wnt-1 or DMBA induced tumorigenesis. Molecular Cancer Epub 3/6/2009 PMID: 19267898

Herynk, M.H., Lewis, M.T., Hopp, T.A., Medina, D., Corona-Rodriguez, A., Cui, Y, Beyer, A.R., and Fuqua, S.A.W. Accelerated mammary maturation and differentiation, and delayed MMTV-neu-induced tumorigenesis of K303R Mutant ERα transgenic mice. Oncogene (2009) June 29 online publication. PMID: 19561644. Impact factor 7.22.

Gu, B., Sun, P., Yuan, Y., Moraes, R., Li., A., Teng, A., Agrawal, A., Rhéaume, C., Bilanchone, V., Veltmaat, J.M., Takemaru, K-I., Millar, S., Lee, E. Y-H. P., Lewis, M.T., Li, B., and Dai, X. Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation. J. Cell Biol. (2009) June 1;185(5):811-26. PMID: 19487454. Impact factor 9.12

De Amicis, F., Thirugnanasampanthan, J., Cui, Y., Selever, J., Beyer, A., Parra, I., Wiegel, N.L., Herynk, M.H., Tsimelzon, A., Lewis, M.T., Chamness, G.C., Hilsenbeck, S.G., Ando, S. and Fuqua, S.A.W. Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells. Breast Can Res and Treat; (2009) Jun 17. [Epub ahead of print.] (2010) May; 121(1); 1-11. PMID: 19533338.

Creighton, C.J., Li, X., Landis, M., Dixon, M.J., Neumeister, V.M., Sjolund, A., Rimm, D.L., Wong, H., Rodriguez, A., Herschkowitz, J.I., Fan, C., Zhang, X., He, X., Pavlick, A., Gutierrez, M.C., Renshaw, L., Larionov, A.A., Faratian, D., Hilsenbeck, S.G., Perou, C.M., **Lewis, M.T., ** Rosen, J. M., Chang, J.C. (**co-senior authors). Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. PNAS (2009) Aug 18; 106(33):13820-5. Epub 2009 Aug 3. Impact factor 9.38. PMID: 19666588. PMCID: PMC2720409.

Zhang X., Harrington N., Moraes R., Wu M., Hilsenbeck S., Lewis M.T., (2008) Cyclopamine inhibition of human breast cancer growth independent of Smoothened (Smo). Breast Cancer Research and Treatment. Epub 2008 Jun 19, PMID: 18563554

Siwko S.K., Dong J., Lewis M.T., Liu H., Hilsenbeck S.G., and Li Y. Evidence that an early pregnancy causes a persistent decrease in the number of functional mammary epithelial stem cells-implications for pregnancy-induced protection against breast cancer. Stem Cells 12:3205-9. Epub 9/11/2008. ) Impact factor 7.741. PMID: 18787212.

Li X.*, Lewis M.T.*, Huang J., Gutierrez C., Osborne C.K., Wu M., Hilsenbeck S.G., Pavlick A., Chamness G., Wong H., Rosen J., and Chang J.C. (2008) Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J. Natl. Cancer Inst. 100:672-679. Epub 2008 Apr 29, PMID: 18445819. * Co-first authors. Impact factor 14.933.




Lewis M.T. (2008) Faith, heresy, and the cancer stem cell hypothesis. Future Oncology 5:585-589 (Invited editorial)




Moraes R.C., Zhang X., Harrington N., Fung J.Y., Wu M-F., Hilsenbeck S.G., Allred D.C., and Lewis M.T. (2007) Constitutive activation of Smoothened (Smo) in mammary glands of transgenic mice leads to increased proliferation, altered differentiation, and ductal dysplasia. Development 134:1231-42. Impact factor 7.29. PMID: 17287253.

Kim H.J., Litzenburger B.C., Cui X., Delgado D.A., Grabiner B.C., Lin X., Lewis M.T., Gottardis M.M.,Wong T.W., Attar R.M., Carboni J., Lee A.V. (2007) Constitutively active IGF-IR causes transformation and xenograft growth of immortalized mammary epithelial cells, and is accompanied by an epithelial to mesenchymal transition mediated by NF-kappaβ and Snail. Mol. Cell. Biol. 27:3165-75. PMID: 17296734.




Lewis M.T. and Visbal A.P. (2006) Hedgehog signaling, stem cells, and breast cancer: connections and controversies. Ernst Schering Fdn. Symposium Proceedings. 5:181-217. (Invited review)

Hinck L., Lewis M.T., Egan S. (2006) Milking biological diversity for all it is worth: lessons from alternative developmental models. J. Mammary Gland Biol. Neoplasia. 3:183-185. (Commentary)

Du Z., Podsypanina K., Huang S., McGrath A., Toneff M.J., Bogoslovskaia E., Zhang X., Moraes R.C., Fluck M., Allred D.C. Lewis M.T., Varmus H.E., and Li Y. (2006) Introduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models. Proc. Natl. Acad. Sci. 103:17396-401. Impact factor 9.643. PMID: 17090666.




Chang J.C., Wooten E.C., Tsimelzon A., Hilsenbeck S.G., Gutierrez M.C., Tham Y.L., Kalidas M., Elledge R., Mohsin S., Osborne C.K., Chamness G.C., Allred D.C., Lewis M.T., Wong H., O’Connell P. (2005) Patterns of resistance and incomplete response to docetaxel (Taxotere) by gene expression profiling in breast cancer patients. Journal of Clinical Oncology 23(6):1169-77. Impact factor 11.81. PMID: 15718313.




Salomon D.S., and Lewis M.T. (2004) Embryogenesis and Oncogenesis: Dr. Jekyll and Mr. Hyde. J. Mammary Gland Biol. Neoplasia. 9:105-7. (Commentary)

Lewis M.T., and Veltmaat J.M. (2004) Next stop, the twilight zone: hedgehog network regulation of mammary gland development. J. Mammary Gland Bio. Neoplasia 9:165-181. (Invited review)