Zechiedrich Lab Research

A Systems Approach to Combating Antibiotic Resistance in Gram-Negative Pathogens


Although drug-resistant bacteria are one of the most critical problems facing the medical community today, huge gaps remain in our knowledge of how cells resist drugs. In our work to understand how gram-negative pathogens respond to and resist treatment with antibiotics, we quickly realized the importance of the patient to antibiotic treatment outcome and known antibiotic resistance mechanisms cannot explain resistance found in bacteria isolated from patients. Ultimately, our results may be used to design better chemotherapeutics to help prevent the worldwide problem of drug resistance.


Current Lab Member Working in This Area of Research



  • 1998-2002 Burroughs Wellcome Fund New Investigator Award
  • 1998-1999 Curtis Hankamer Research Award
  • 2001-2005 National Science Foundation (MCB 0090880)
  • 2003-2006 Houston Area Molecular Biophysics Program (T32 GM08280)
  • 2004-2006 Burroughs Wellcome Fund Research Grant (1005267)
  • 2004-2010 Pharmacoinformatics Training Program (NIH T90 DK070109)
  • 2004-2013 National Institutes of Health (RO1 AI054830)
  • 2009 Applied Biosystems SOLID™3 System $10K Genome Award
  • 2014-2015 National Institutes of Health (R56 AI 054830)
  • 2015-2019 National Institutes of Health (RO1 GM115501)