Frank Horrigan Lab



Tanner MR, Hu X, Huq R, Tajhya RB, Sun L, Khan FS, Laragione T, Horrigan FT, Gulko PS, Beeton C. KCa1.1 inhibition attenuates fibroblast-like synoviocyte invasiveness and ameliorates rat models of rheumatoid arthritis. Arthritis Rheumatol. 2014 Sep 23. doi: 10.1002/art.38883. [Epub ahead of print] PMID:25252152

Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XH. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25;129(12):1276-85. doi: 10.1161/CIRCULATIONAHA.113.006611. Epub 2014 Jan 7. PMID:24398018

Horrigan FT. Perspectives on: conformational coupling in ion channels: conformational coupling in BK potassium channels. J Gen Physiol. 2012 Dec;140(6):625-34. doi: 10.1085/jgp.201210849. PMID:23183698

Hu X, Laragione T, Sun L, Koshy S, Jones KR, Ismailov II, Yotnda P, Horrigan FT, Gulko PS, Beeton C. KCa1.1 potassium channels regulate key proinflammatory and invasive properties of fibroblast-like synoviocytes in rheumatoid arthritis. J Biol Chem. 2012 Feb 3;287(6):4014-22. doi: 10.1074/jbc.M111.312264. Epub 2011 Nov 10. PMID:22074915

Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin). 2009 Jul-Aug;3(4):249-58. Epub 2009 Jul 17. PMID:19617704

Wu Y, Xiong Y, Wang S, Yi H, Li H, Pan N, Horrigan FT, Wu Y, Ding J. Intersubunit coupling in the pore of BK channels. J Biol Chem. 2009 Aug 28;284(35):23353-63. doi: 10.1074/jbc.M109.027789. Epub 2009 Jun 26. PMID:19561088

Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nat Struct Mol Biol. 2008 Nov;15(11):1130-2. doi: 10.1038/nsmb1108-1130. No abstract available. PMID:18985066

Ma Z, Wong KY, Horrigan FT. An extracellular Cu2+ binding site in the voltage sensor of BK and Shaker potassium channels. J Gen Physiol. 2008 May;131(5):483-502. doi: 10.1085/jgp.200809980. PMID:18443360

Horrigan FT, Ma Z. Mg2+ enhances voltage sensor/gate coupling in BK channels. J Gen Physiol. 2008 Jan;131(1):13-32. doi: 10.1085/jgp.200709877. PMID:18166624

Yang H, Hu L, Shi J, Delaloye K, Horrigan FT, Cui J. Mg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channels. Proc Natl Acad Sci U S A. 2007 Nov 13;104(46):18270-5. Epub 2007 Nov 5. PMID:17984060

Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Acc Chem Res. 2006 Dec;39(12):918-24. Review. PMID:17176030

Ma Z, Lou XJ, Horrigan FT. Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol. 2006 Mar;127(3):309-28. PMID:16505150

Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. J Gen Physiol. 2005 Jul;126(1):7-21. Epub 2005 Jun 13. PMID:15955873

Zhang G, Horrigan FT. Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels. J Gen Physiol. 2005 Feb;125(2):213-36. PMID:15684095

Hu L, Shi J, Ma Z, Krishnamoorthy G, Sieling F, Zhang G, Horrigan FT, Cui J. Participation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10488-93. Epub 2003 Aug 18. PMID:12925732

Horrigan FT, Aldrich RW. Coupling between voltage sensor activation, Ca2+ binding and channel opening in large conductance (BK) potassium channels. J Gen Physiol. 2002 Sep;120(3):267-305. Erratum in: J Gen Physiol. 2002 Oct;120(4):599. PMID:12198087


Horrigan F.T. , Cannell M.B. and Bookman, R.J. A rapidly switching, filter-based excitation system for fluorescence microscopy. Licensed to Sutter Instrument Company and marketed as “Lambda DG-4 : ultra high speed wavelength switcher”.