Positions

Associate Professor of Surgery
Division of Cardiothoracic Surgery
Baylor College of Medicine

Education

Residency from University of Tokyo School of Medicine
Ph.D. from University of Tokyo
M.D. from Tokyo Medical and Dental University

Professional Interests

  • In situ cardiac regeneration
  • Cardiovascular disease
  • Cardiac cellular reprogramming

Professional Statement

In 2010, it was reported that a combination of three transcription factors— Gata4, Mef2c, and Tbx5— reprogrammed postnatal murine cardiac fibroblasts directly into differentiated cardiomyocyte-like cells in vitro.

Recently, several researchers, including our group, reported that resident cardiac fibroblasts were reprogrammed into cardiomyocyte-like cells in the murine heart by direct injection of Gata4, Mef2c, Tbx5 into the myocardium after coronary ligation. These results raise the possibility that we can generate new cardiomyocytes from scar tissue after myocardial infarction in humans.

Selected Publications

  • Mathison M, P Gersch R, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK. "In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.." J Am Heart Assoc. 2012;1(6)
  • Cui J, Li J, Mathison M, Tondato F, Mulkey SP, Micko C, Chronos NA, Robinson KA. "A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials.." Cardiovasc Revasc Med. 2005;6(3):113-120.
  • Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF. "Extracellular matrix scaffold for cardiac repair.." Circulation. 2005;112
  • Mathison MN, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Lima MM. "Implications of problematic access in transluminal endografting of abdominal aortic aneurysm.." J Vasc Interv Radiol. 2003;14(1)
  • Becker GJ, Kovacs M, Mathison MN. "Transluminal repair of abdominal aortic aneurysm: a call for selective use, careful surveillance, new device design, and systematic study of transrenal fixation.." J Vasc Surg. 2002;35(3):611-615.