Megumi Mathison, M.D., Ph.D.

Associate Professor of Surgery

(713) 798-3259

Email

Megumi.Mathison@bcm.edu

Positions

Associate Professor of Surgery: Division of Cardiothoracic Surgery
Baylor College of Medicine

Addresses

Alkek Building for Biomedical Research (Office): Room: ABBR-411
Houston, TX, 77030
United States

Education

Residency from University of Tokyo School of Medicine: ., Tokyo, Japan

Ph.D. from University of Tokyo: ., Tokyo, Japan

M.D. from Tokyo Medical and Dental University: ., Tokyo, Japan

Professional Interests

In situ cardiac regeneration
Cardiovascular disease
Cardiac cellular reprogramming

Professional Statement

In 2010, it was reported that a combination of three transcription factors— Gata4, Mef2c, and Tbx5— reprogrammed postnatal murine cardiac fibroblasts directly into differentiated cardiomyocyte-like cells in vitro.

Recently, several researchers, including our group, reported that resident cardiac fibroblasts were reprogrammed into cardiomyocyte-like cells in the murine heart by direct injection of Gata4, Mef2c, Tbx5 into the myocardium after coronary ligation. These results raise the possibility that we can generate new cardiomyocytes from scar tissue after myocardial infarction in humans.

Websites

Dr. Mathison's Research

Laboratory for Cardiac Regeneration

Division of Cardiothoracic Surgery

Selected Publications

Mathison M, P Gersch R, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK. " In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.. " J Am Heart Assoc. 2012 ; 1 (6)
Cui J, Li J, Mathison M, Tondato F, Mulkey SP, Micko C, Chronos NA, Robinson KA. " A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials.. " Cardiovasc Revasc Med. 2005 ; 6 (3) : 113-120.
Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF. " Extracellular matrix scaffold for cardiac repair.. " Circulation. 2005 ; 112
Mathison MN, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Lima MM. " Implications of problematic access in transluminal endografting of abdominal aortic aneurysm.. " J Vasc Interv Radiol. 2003 ; 14 (1)
Becker GJ, Kovacs M, Mathison MN. " Transluminal repair of abdominal aortic aneurysm: a call for selective use, careful surveillance, new device design, and systematic study of transrenal fixation.. " J Vasc Surg. 2002 ; 35 (3) : 611-615.
Mathison M, Singh VP, Gersch RP, et al. " "Triplet" Polycistronic Vectors Encoding Gata4, Mef2c, and Tbx5 Enhances Postinfarct Ventricular Functional Improvement Compared With Singlet Vectors " J Thorac Cardiovasc Sug. 2014 Oct ; 148 (4) : 1656-1664.
Pubmed PMID: 24755332.
Mathison M, Edgerton JR, Horswell L, et al.. " Analysis of Hemodynamic Changes During Beating Heart Surgical Procedures " Ann Thorac Surg. 2000 Oct ; 70 (4) : 1355-1360.
Pubmed PMID: 11081898.
Mathison M, Singh VP, Chiuchiolo M, et al.. " In Situ Reprogramming to Transdifferentiate Fibroblasts Into Cardiomyocytes Using Adenoviral Vectors: Implications for Clinical Myocardial Regeneration " J Thorac Cardiovasc Surg. 2017 Feb ; 153 (2) : 329-339.
Pubmed PMID: 27773576.
Mathison M, Singh VP, Sanagasetti D, et al.. " Cardiac Reprogramming Factor Gata4 Reduces Postinfarct Cardiac Fibrosis Through Direct Repression of the Profibrotic Mediator Snail " J Thorac Cardiovasc Surg. 2017 Nov ; 154 (5) : 1601-1610.
Pubmed PMID: 28711329.
Mathison M, Rosengart TK. " Heart Regeneration: The Endothelial Cell Comes First " J Thorac Cardiovasc Surg. 2018 Mar ; 155 (3) : 1128-1129.
Pubmed PMID: 29452462.