Positions

Associate Professor and CPRIT Scholar
Pharmacology and Chemical Biology
Baylor College of Medicine
Houston, Texas, United States
Associate Professor
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States

Education

BS from Peking University
Chemistry
PhD from The Ohio State University
Organic Chemistry
Postdoctoral Training at University of North Carolina at Chapel Hill
Drug Delivery and Nanomedicine

Professional Interests

  • Chemical Biology, Sensing and Imaging, Drug Discovery, and Drug Delivery

Professional Statement

The overarching goal for my research is to develop new tools to address biological questions and new therapies to improve human health, taking advantage of my unique experience in organic and medicinal chemistry, drug delivery, material sciences, cell biology and preclinical studies. My laboratory has developed the first reversible reaction-based fluorescent probe to monitor glutathione (GSH) dynamics in living cells and the first potent and safe small molecule inhibitor (SMI) for steroid receptor coactivator-3 (SRC-3) as a novel targeted cancer therapy. Additionally, we develop novel antibody-drug conjugates to target P53 defective cancer.

Selected Publications

Intellectual Property

Probes for Quantitative Imaging of Thiols in Various Environments
Co Inventors: Xiqian Jiang; Jianwei Chen
Multi-arm biodegradable polymers for nucleic acid delivery
Co Inventors: Fude Feng
Next Generation Small Molecule Regulators for Steroid Receptor Coactivators
Co Inventors: Bert W. O’Malley, David M. Lonard, Jianming Xu, and Jianwei Chen