Positions

Associate Professor
Department of Neuroscience
Baylor College of Medicine
Houston, TX, US
Associate Professor
Center for Cell and Gene Therapy
Baylor College of Medicine
Houston, Texas, United States
Associate Professor
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States
Visiting Associate Professor
Neuroscience
Ohio State University Medical Center
Columbus, Ohio, United States
Assistant Professor
Neuropathology
Harvard Medical School
Boston, Massachusetts, United States
Instructor
Neuropathology
Harvard Medical School
Boston, Massachusetts, United States
Assistant Professor
Biotechnology
Baylor College of Medicine
Houston, Texas, United States
Assistant Professor
Neurosurgery
Baylor College of Medicine
Houston, Texas, United States
Assistant Professor
Molecular and Cellular Biology
Baylor College of Medicine
Houston, Texas, United States
Assistant Professor
Neuroscience
Baylor College of Medicine
Houston, Texas, United States

Education

Post-Doctoral Fellowship at Harvard Medical School
PhD from University Of Texas Medical School At Galveston
MA from University Of Texas At Austin
BA from University Of Texas At Austin
BA from Texas Tech University

Professional Interests

  • Gene therapy of the nervous system
  • Spinal Cord Injury
  • Neuroimmunology of neural trauma

Professional Statement

The research interests of our laboratory focus on the molecular and cellular bases of disease and trauma of the nervous system with a translational emphasis. Our primary research emphasis is the study of the role of neurotrophic factors in CNS degeneration and regeneration as a consequence of trauma or neurodegenerative disease and their possible therapeutic use. Using viral vectors carrying genes for neurotrophic factors we have shown in animal models of CNS injury we can spare neurons from axotomy-induced neuronal death and support axonal sprouting after neural injury. Recently, we learned that neuroinflammation is required for regenerative effects of the neurotrophic factors and are now studying this phenomenon to determine its mechanism.

Techniques used in the laboratory span from gene cloning, through small animal neurosurgery, light and confocal microscopy, neuroimmunology, to animal behavior.

Selected Publications

Funding

Identification of T cell subtypes necessary for NT-3 induced neuroplasticity using a novel human-to-rat graft strategy
Mission Connect
Inflammation-associated factors that support neuroplasticity in chronic spinal cord injury
Christopher and Dana Reeve Foundation