Positions

Assistant Professor
Medicine-Cardiovascular Sciences
Baylor College of Medicine
Houston, TX, US
Consultant
Indus Instruments
Houston, Texas, United States

Education

Post-doctoral Associate from Baylor College Of Medicine
Ph.D. from Texas A&M University
M.S. from University Of Akron
B.E. from Osmania University

Honors & Awards

NIH Research Career Development Award

Professional Statement

Dr. Reddy’s research interests include evaluation of cardiac and vascular mechanics in senescent, disease, transgenic, and surgical models of mice. Some of the rodent models he studies include atherosclerosis, dwarf, myocardial infarction/remodeling, pressure overload, hypertension, absent vascular tone, and absent steroid receptor coactivator-1, with the main goal being to translate what is learned in mice to humans for early detection and screening.

Using noninvasive methods, such as pulsed Doppler Flow Velocity measurements as well as imaging methods, animals are phenotyped as abnormalities develop and progress, and their cardiovascular system is monitored as it adapts and compensates for the deterioration of function or for missing or over-expressed proteins. The main goal is to translate what is learned in mice to humans for detection and screening of cardiovascular diseases at an early stage when potential therapies can be most effective at preventing disease progression.

Dr. Reddy’s research dates back to 1997 when he began working with Dr. Craig Hartley in developing the first Doppler Flow Velocity signal acquisition and processing systems. Using the custom-built sensors and devices the laboratory adapted these measurement techniques from large animals and humans, using them to assess cardiovascular function in mice and other rodents. Over almost two decades Dr. Reddy’s research has included the use of Doppler Flow Velocity measurements (without image guidance) to measure cardiac velocities, blood flow velocities in central and peripheral vessels, coronary flow velocity, stenotic jet velocity, arterial pulse-wave velocity, tail-cuff blood pressure, arterial wall motion, and tissue Doppler. Imaging methods are used when cardiac and vascular dimensions are required, while invasive methods are used mainly to measure aortic, arterial, and left ventricular pressure. Efforts are underway to develop non-invasive indices of aortic impedance and LV systemic load using aortic wall motion and velocity measurements and more recently we have found indications that peak aortic blood acceleration correlates well with left ventricular dp/dtmax potentially removing the need for this invasive measurement as well.

Memberships

American Heart Association
American Association for Laboratory Animal Science