Email

areddy@bcm.edu

Positions

Assistant Professor

Medicine-Cardiovascular Sciences
Baylor College of Medicine
Houston, TX US

Consultant

Indus Instruments
Houston, Texas United States

Education

Postdoctoral Fellowship at Baylor College of Medicine

03/2001 - Houston, Texas United States

PhD from Texas A&M University

12/1996 - College Station, Texas United States

MS from University of Akron

05/1991 - Akron, Ohio United States

BE from Osmania University

08/1985 - Hyderabad, Telangana India

Honors & Awards

NIH Research Career Development Award

01/2005 - 01/2010

Professional Statement

Dr. Reddy’s research interests include evaluation of cardiac and vascular mechanics in senescent, disease, transgenic, and surgical models of mice. Some of the rodent models he studies include atherosclerosis, dwarf, myocardial infarction/remodeling, pressure overload, hypertension, absent vascular tone, and absent steroid receptor coactivator-1, with the main goal being to translate what is learned in mice to humans for early detection and screening.

Using noninvasive methods, such as pulsed Doppler Flow Velocity measurements as well as imaging methods, animals are phenotyped as abnormalities develop and progress, and their cardiovascular system is monitored as it adapts and compensates for the deterioration of function or for missing or over-expressed proteins. The main goal is to translate what is learned in mice to humans for detection and screening of cardiovascular diseases at an early stage when potential therapies can be most effective at preventing disease progression. Dr. Reddy’s research dates back to 1997 when he began working with Dr. Craig Hartley in developing the first Doppler Flow Velocity signal acquisition and processing systems. Using the custom-built sensors and devices the laboratory adapted these measurement techniques from large animals and humans, using them to assess cardiovascular function in mice and other rodents. Over almost two decades Dr. Reddy’s research has included the use of Doppler Flow Velocity measurements (without image guidance) to measure cardiac velocities, blood flow velocities in central and peripheral vessels, coronary flow velocity, stenotic jet velocity, arterial pulse-wave velocity, tail-cuff blood pressure, arterial wall motion, and tissue Doppler. Imaging methods are used when cardiac and vascular dimensions are required, while invasive methods are used mainly to measure aortic, arterial, and left ventricular pressure. Efforts are underway to develop non-invasive indices of aortic impedance and LV systemic load using aortic wall motion and velocity measurements and more recently we have found indications that peak aortic blood acceleration correlates well with left ventricular dp/dtmax potentially removing the need for this invasive measurement as well.

Websites

Selected Publications

• Moudgil R, Samra G, Ko KA, Vu HT, Thomas TN, Luo W, Chang J, Reddy AK, Fujiwara K, Abe J-I "Topoisomerase 2B decrease results in diastolic dysfunction via p53 and Akt: A novel pathway.." Front Cardiovasc Med.2020/November;7:594123. doi: 10.3389/fcvm.2020.594123. Pubmed PMID: 33330654
• Cieslik KA, Sekhar RV, Granillo A, Reddy AK, Medrano G, Heredia CP, Entman ML, Hamilton DJ, Li S, Reineke E, Gupte AA, Zhang A, Taffet GE. "Improved cardiovascular function in old mice after n-acetyl cysteine and glycine supplemented diet: Inflammation and mitochondrial factors.." J Gerontol - A Biol Sci Med Sci.2018;73(9):1167-1177. Pubmed PMID: 29538624
• Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH. "Argininosuccinate lyase deficiency causes an endothelial-dependent form of hypertension.." Am J Human Genet.2018;103(2):276-287. Pubmed PMID: 30075114
• Salazar BH, Hoffman KA, Reddy AK, Madala S, Birla RK. "16-Channel flexible system to measure electrophysiological properties of bioengineered hearts.." Cardiovasc Engineer Technol.2018;9(1):94-104. Pubmed PMID: 29150791

Memberships

American Heart Association

Professional Member (01/2005)

American Association for Laboratory Animal Science

Member (08/2013)