Email

wu.chen@bcm.edu

Positions

Instructor

Department of Neuroscience
Baylor College Of Medicine
Houston, Texas, United States

Education

Internship at Tulane University

New Orleans, Louisiana, United States

Neuroscience, Mentor: Dr. Jeffrey Tasker

PhD from Louisiana Tech University

Ruston, Louisiana, United States

Biomedical Engineering, Mentor: Dr. Alan Chiu

Postdoctoral Fellowship at University of Michigan

Ann Arbor, Michigan, United States

Neurology, Mentor: Dr. William Stacey

Postdoctoral Fellowship at Baylor College of Medicine

Houston, Texas, United States

Neuroscience, Mentor: Dr. Mingshan Xue

Honors & Awards

Dean’s Award for Excellence

Baylor College of Medicine

Young Investigator Award

American Epilepsy Society

Professional Interests

• Neural Signal Processing
• Gene Therapy
• Neurological Disorders

Selected Publications

• Chen W, Cai ZL, Chao ES, Chen H, Longley CM, Hao S, Chao HT, Kim JH, Messier JE, Zoghbi HY, Tang J, Swann JW, Xue M. " Stxbp1/Munc18-1 haploinsufficiency impairs inhibition and mediates key neurological features of STXBP1 encephalopathy " eLife. 2020 Feb 19; 9 : e48705.
  Pubmed PMID: 32073399.
• Yin J, Chen W, Chao ES, Soriano S, Wang L, Wang W, Cummock SE, Tao H, Pang K, Liu Z, Pereira FA, Samaco RC, Zoghbi HY, Xue M, Schaaf CP. " Otud7a Knockout Mice Recapitulate Many Neurological Features of 15q13.3 Microdeletion Syndrome " Am J Hum Genet. 2018 Feb 1; 102 (2) : 296-308.
  Pubmed PMID: 29395075.
• Yin J, Chen W, Yang H, Xue M, Schaaf CP. " Chrna7 deficient mice manifest no consistent neuropsychiatric and behavioral phenotypes " Sci Rep. 2017 Jan 3; 7 : 39941.
  Pubmed PMID: 28045139.
• Luna-Munguia H, Starski P, Chen W, Gliske S, Stacey WC. " Control of in vivo ictogenesis via endogenous synaptic pathways " Sci Rep. 2017 May 2; 7 (1) : 1311.
  Pubmed PMID: 28465556.
• Ure K, Lu H, Wang W, Ito-Ishida A1,2, Wu Z2,4, He LJ, Sztainberg Y, Chen W, Tang J, Zoghbi HY. " Restoration of Mecp2 expression in GABAergic neurons is sufficient to rescue multiple disease features in a mouse model of Rett syndrome " eLife. 2016 Jun 21; 5 : e14198.
  Pubmed PMID: 27328321.
• Meng X, Wang W, Lu H, He LJ, Chen W, Chao ES, Fiorotto ML, Tang B, Herrera JA, Seymour ML, Neul JL, Pereira FA, Tang J, Xue M, Zoghbi HY. " Manipulations of MeCP2 in glutamatergic neurons highlight their contributions to Rett and other neurological disorders " eLife. 2016 Jun 21; 5 : e14199.
  Pubmed PMID: 27328325.
• Chen W, Cahoy DO, Tasker JG, Chiu AW. " Kernel duration and modulation gain in coupled oscillator model and their implications on the progression of seizures " Network. 2012 May 9; 23 (1-2) : 59-75.
  Pubmed PMID: 22571251.
• Lee D*, Chen W*#, Kaku HN*, Zhou X*, Chao ES, Soriano A, Kuncheria A, Flores S, Kim JH, Rigo F, Jafar-nejad P, Beaudet AL, Caudill MS, Xue M#. " Antisense oligonucleotide therapy rescues disturbed brain rhythms and sleep in juvenile and adult mouse models of Angelman syndrome " eLife. 2023 Jan 3; 12 : e81892.
  Pubmed PMID: 36594817.

Show 4 more publications

Projects

AAV-Mediated Gene Replacement Therapy in a mouse model of STXBP1-Related Developmental and Epileptic Encephalopathy

Baylor College of Medicine

Reactivating paternal Ube3a alleviates the disturbance of brain rhythms and sleep in juvenile and adult Angelman syndrome mouse models

Baylor College of Medicine

Transgenic Mouse Models of STXBP1-Related Pediatric Epileptic Encephalopathies

Baylor College of Medicine

Funding

Postdoctoral Research Fellowship

American Epilepsy Society

2020 NRI Zoghbi Scholar Award

Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital

2022 Young Investigator Award

Uplifting Athletes